Search Results - "Donnelly, Karla L."

Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase by Shankaran, K, Donnelly, Karla L, Shah, Shrenik K, Guthikonda, Ravindra N, MacCoss, Malcolm, Humes, John L, Pacholok, Stephen G, Grant, Stephan K, Kelly, T.M, Wong, K.K

“…Synthesis and evaluation of pyrrolidin-2-imines (X = CHR 1) and 1,3-thiazolidin-2-imines (X = S) as inhibitors of nitric oxide synthase (NOS) are discussed…”
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Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases by Shankaran, K., Donnelly, Karla L., Shah, Shrenik K., Caldwell, Charles G., Chen, Ping, Hagmann, William K., MacCoss, Malcolm, Humes, John L., Pacholok, Stephen G., Kelly, Theresa M., Grant, Stephan K., Wong, Kenny K.

“…The preparation and SAR of a series of iNOS inhibitors leading to the most potent compound, incorporating a (1,4)-5-imino thiazepane (R = n-Pr) is disclosed. A…”
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Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor by Shankaran, K., Donnelly, Karla L., Shah, Shrenik K., Guthikonda, Ravindra N., MacCoss, Malcolm, Mills, Sander G., Gould, Sandra L., Malkowitz, Lorraine, Siciliano, Salvatore J., Springer, Martin S., Carella, Anthony, Carver, Gwen, Hazuda, Daria, Holmes, Karen, Kessler, Joseph, Lineberger, Janet, Miller, Michael D., Emini, Emilio A., Schleif, William A.

“…A series of pyrrolidineacetic acid derivatives ( 1) was prepared and assayed for their CCR5 receptor affinity, anti-HIV-1 activity in a HeLa cell-based assay,…”
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Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists by Shankaran, K., Donnelly, Karla L., Shah, Shrenik K., Caldwell, Charles G., Chen, Ping, Finke, Paul E., Oates, Bryan, MacCoss, Malcolm, Mills, Sander G., DeMartino, Julie A., Gould, Sandra L., Malkowitz, Lorraine, Siciliano, Salvatore J., Springer, Martin S., Kwei, Gloria, Carella, Anthony, Carver, Gwen, Danzeisen, Renee, Hazuda, Daria, Holmes, Karen, Kessler, Joseph, Lineberger, Janet, Miller, Michael D., Emini, Emilio A., Schleif, William A.

“…Ongoing efforts from these laboratories have resulted in the identification of 5-(piperidin-1-yl)-3-phenylpentylsulfones as a potent CCR5 antagonists. The…”
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Inhibition of nitric oxide synthase by benzoxazolones by Shankaran, K, Donnelly, Karla L, Shah, Shrenik K, Humes, John L, Pacholok, Stephen G, Grant, Stephan K, Green, Barbara G, MacCoss, Malcolm

“…A series of benzoxazolones has been synthesized using modifications of literature methods. The synthetic benzoxazolone analogs, along with commercially…”
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Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-dentylsulfones as CCR5 antagonists by SHANKARAN, K, DONNELLY, Karla L, GOULD, Sandra L, MALKOWITZ, Lorraine, SICILIANO, Salvatore J, SPRINGER, Martin S, KWEI, Gloria, CARELLA, Anthony, CARVER, Gwen, DANZEISEN, Renee, HAZUDA, Daria, HOLMES, Karen, SHAH, Shrenik K, KESSLER, Joseph, LINEBERGER, Janet, MILLER, Michael D, EMINI, Emilio A, SCHLEIF, William A, CALDWELL, Charles G, PING CHEN, FINKE, Paul E, OATES, Bryan, MACCOSS, Malcolm, MILLS, Sander G, DEMARTINO, Julie A

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