Search Results - "Donnelly, Dustin"

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury by Donnelly, Dustin J., Popovich, Phillip G.

“…Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and activation of systemic immunity with the capacity to exacerbate…”
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Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord by Kigerl, Kristina A, Gensel, John C, Ankeny, Daniel P, Alexander, Jessica K, Donnelly, Dustin J, Popovich, Phillip G

“…Macrophages dominate sites of CNS injury in which they promote both injury and repair. These divergent effects may be caused by distinct macrophage subsets,…”
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Particle-tethered NADH for production of methanol from CO2 catalyzed by coimmobilized enzymes by El-Zahab, Bilal, Donnelly, Dustin, Wang, Ping

“…Efficient cofactor regeneration and reuse are highly desired for many important biotransformation applications. Here we show for the first time that cofactor…”
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Minimally Invasive Muscle Sparing Posterior-Only Approach for Lumbar Circumferential Decompression and Stabilization to Treat Spine Metastasis—Technical Report by Donnelly, Dustin J, Abd-El-Barr, Muhammad M, Lu, Yi

“…Objective Palliative tumor resection and subsequent stabilization are important for maximizing function and quality of life for patients suffering from spinal…”
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Acute microglia ablation induces neurodegeneration in the somatosensory system by Rubino, Stephen J., Mayo, Lior, Wimmer, Isabella, Siedler, Victoria, Brunner, Florian, Hametner, Simon, Madi, Asaf, Lanser, Amanda, Moreira, Thais, Donnelly, Dustin, Cox, Laura, Rezende, Rafael Machado, Butovsky, Oleg, Lassmann, Hans, Weiner, Howard L.

“…Previous studies have reported that microglia depletion leads to impairment of synapse formation and these cells rapidly repopulate from CNS progenitors…”
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An efficient and reproducible method for quantifying macrophages in different experimental models of central nervous system pathology by Donnelly, Dustin J., Gensel, John C., Ankeny, Daniel P., van Rooijen, Nico, Popovich, Phillip G.

“…Historically, microglia/macrophages are quantified in the pathological central nervous system (CNS) by counting cell profiles then expressing the data as…”
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Open Reduction in Traumatic Cervical Facet Dislocation Does Not Delay Time to Treatment by Yaffe, Noah M, Labak, Collin M, Kumar, Pranav, Herring, Eric, Donnelly, Dustin J, Smith, Gabriel

“…Background Cervical facet dislocation is a serious injury that can result in permanent neurologic damage. Current guidelines recommend immediate closed…”
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Disruption of the ATP/adenosine balance in CD39−/− mice is associated with handling‐induced seizures by Lanser, Amanda J., Rezende, Rafael M., Rubino, Stephen, Lorello, Paul J., Donnelly, Dustin J., Xu, Huixin, Lau, Lauren A., Dulla, Chris G., Caldarone, Barbara J., Robson, Simon C., Weiner, Howard L.

“…Summary Seizures are due to excessive, synchronous neuronal firing in the brain and are characteristic of epilepsy, the fourth most prevalent neurological…”
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Spinal cord injury therapies in humans: an overview of current clinical trials and their potential effects on intrinsic CNS macrophages by Gensel, John C, Donnelly, Dustin J, Popovich, Phillip G

“…Macrophage activation is a hallmark of spinal cord injury (SCI) pathology. CNS macrophages, derived from resident microglia and blood monocytes, are ubiquitous…”
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Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells by Gabriely, Galina, Ma, Duanduan, Siddiqui, Shafiuddin, Sun, Linqing, Skillin, Nathaniel P., Abou-El-Hassan, Hadi, Moreira, Thais G., Donnelly, Dustin, da Cunha, Andre P., Fujiwara, Mai, Walton, Lena R., Patel, Amee, Krishnan, Rajesh, Levine, Stuart S., Healy, Brian C., Rezende, Rafael M., Murugaiyan, Gopal, Weiner, Howard L.

“…Myeloid suppressor cells promote tumor growth by a variety of mechanisms which are not fully characterized. We identified myeloid cells (MCs) expressing the…”
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Deficient CX3CR1 signaling promotes recovery after mouse spinal cord injury by limiting the recruitment and activation of Ly6Clo/iNOS+ macrophages by Donnelly, Dustin J, Longbrake, Erin E, Shawler, Todd M, Kigerl, Kristina A, Lai, Wenmin, Tovar, C Amy, Ransohoff, Richard M, Popovich, Phillip G

“…Macrophages exert divergent effects in the injured CNS, causing either neurotoxicity or regeneration. The mechanisms regulating these divergent functions are…”
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Gamma-delta T cells suppress microbial metabolites that activate striatal neurons and induce repetitive/compulsive behavior in mice by Cox, Laura M., Tatematsu, Bruna K., Guo, Lydia, LeServe, Danielle S., Mayrink, Julia, Oliveira, Marilia G., Donnelly, Dustin, Fonseca, Roberta C., Lemos, Luisa, Lanser, Toby B., Rosa, Ana C., Lopes, Juliana R., Schwerdtfeger, Luke A., Ribeiro, Gabriela F.C., Lobo, Eduardo L.C., Moreira, Thais G., Oliveira, Andre G., Weiner, Howard L., Rezende, Rafael M.

“…•γδ T cells regulate the gut microbiota.•In the absence of γδ T cells, mice develop a microbial dysbiosis with the growth of microbes involved in the…”
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Contemporary surgical strategies for spinal metastasis; case closed? by Tafel, Ian, Donnelly, Dustin, Chi, John

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Robotic-Assisted Trajectory Into Kambin's Triangle During Percutaneous Transforaminal Lumbar Interbody Fusion—Initial Case Series Investigating Safety and Efficacy by Dalton, Tara, Sykes, David, Wang, Timothy Y, Donnelly, Dustin, Than, Khoi D, Karikari, Isaac O, Goodwin, C Rory, Gupta, Dhanesh K, Wiggins, Walter F, Abd-El-Barr, Muhammad M

“…Abstract BACKGROUND Minimally invasive spine surgery (MISS) has the potential to further advance with the use of robot-assisted (RA) techniques. While RA…”
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Disruption of the ATP /adenosine balance in CD 39 −/− mice is associated with handling‐induced seizures by Lanser, Amanda J., Rezende, Rafael M., Rubino, Stephen, Lorello, Paul J., Donnelly, Dustin J., Xu, Huixin, Lau, Lauren A., Dulla, Chris G., Caldarone, Barbara J., Robson, Simon C., Weiner, Howard L.

“…Summary Seizures are due to excessive, synchronous neuronal firing in the brain and are characteristic of epilepsy, the fourth most prevalent neurological…”
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Endovascular treatment of a ruptured posterior fossa pure arterial malformation: illustrative case by Chua, Melissa M. J., Gupta, Saksham, Essayed, Walid Ibn, Donnelly, Dustin J., Ziayee, Habibullah, Vicenty-Padilla, Juan, Das, Alvin S., Lai, Rosalind P. M., Izzy, Saef, Aziz-Sultan, Mohammad Ali

“…BACKGROUND Pure arterial malformations (PAMs) are rare vascular anomalies that are commonly mistaken for other vascular malformations. Because of their…”
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Clinical Problem-Solving: Lethargy and Fever in an Immunocompromised Patient by Snider, Samuel, Stojanovic, Konstantin, Donnelly, Dustin, Etherton, Mark, Feske, Steven K., Izzy, Saef

“…We present the case of a 63-year-old woman with a glioblastoma multiforme on immunosuppressive steroid doses who developed lethargy and fever. We review the…”
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Particle-tethered NADH for production of methanol from CO^sub 2^ catalyzed by coimmobilized enzymes by El-Zahab, Bilal, Donnelly, Dustin, Wang, Ping

“…Efficient cofactor regeneration and reuse are highly desired for many important biotransformation applications. Here we show for the first time that cofactor…”
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Particle‐tethered NADH for production of methanol from CO 2 catalyzed by coimmobilized enzymes by El‐Zahab, Bilal, Donnelly, Dustin, Wang, Ping

“…Abstract Efficient cofactor regeneration and reuse are highly desired for many important biotransformation applications. Here we show for the first time that…”
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Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury: Spinal cord regeneration and repair by DONNELLY, Dustin J, POPOVICH, Phillip G

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