Search Results - "Donkin, James J"

Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments by Donkin, James J, Vink, Robert

“…Although a number of factors contribute to the high mortality and morbidity associated with traumatic brain injury (TBI), the development of cerebral edema…”
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ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice by Donkin, James J., Stukas, Sophie, Hirsch-Reinshagen, Veronica, Namjoshi, Dhananjay, Wilkinson, Anna, May, Sharon, Chan, Jeniffer, Fan, Jianjia, Collins, Jon, Wellington, Cheryl L.

“…The cholesterol transpoter ATP-binding cassette transporter A1 (ABCA1) moves lipids onto apolipoproteins including apolipoprotein E (apoE), which is the major…”
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Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury by Donkin, James J, Nimmo, Alan J, Cernak, Ibolja, Blumbergs, Peter C, Vink, Robert

“…Brain edema and swelling is a critical factor in the high mortality and morbidity associated with traumatic brain injury (TBI). Despite this, the mechanisms…”
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A substance P antagonist reduces axonal injury and improves neurologic outcome when administered up to 12 hours after traumatic brain injury by Donkin, James J, Cernak, Ibolja, Blumbergs, Peter C, Vink, Robert

“…Previous studies have demonstrated that the compound N-acetyl-L-tryptophan (NAT) reduces brain edema and improves functional outcome following traumatic brain…”
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Downregulation of amyloid precursor protein (APP) expression following post-traumatic cyclosporin-A administration by Van Den Heuvel, Corinna, Donkin, James J, Finnie, John W, Blumbergs, Peter C, Kuchel, Tim, Koszyca, Barbara, Manavis, Jim, Jones, Nigel R, Reilly, Peter L, Vink, Robert

“…The aim of these studies was to assess and quantitate the effects of cyclosporin-A (CyA) on brain APP messenger RNA and neuronal perikaryal APP antigen…”
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Validation of reference genes for normalization of real-time quantitative RT-PCR data in traumatic brain injury by Cook, Naomi L., Vink, Robert, Donkin, James J., van den Heuvel, Corinna

“…Careful validation of reference genes used for the normalization of real‐time RT‐PCR data is required to obtain accurate results regarding gene expression. We…”
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Substance P in traumatic brain injury by Donkin, James J, Turner, Renee J, Hassan, Islam, Vink, Robert

“…Recent evidence has suggested that neuropeptides, and in particular substance P (SP), may play a critical role in the development of morphological injury and…”
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