Search Results - "Donia, Thoria"

Management of oxidative stress and inflammation in cardiovascular diseases: mechanisms and challenges by Donia, Thoria, Khamis, Abeer

“…Cardiovascular diseases (CVDs) have diverse physiopathological mechanisms with interconnected oxidative stress and inflammation as one of the common etiologies…”
Get full text

Synthesis, In Silico and In Vitro Assessment of New Quinazolinones as Anticancer Agents via Potential AKT Inhibition by Noser, Ahmed A, El-Naggar, Mohamed, Donia, Thoria, Abdelmonsef, Aboubakr H

“…A series of novel quinazolinone derivatives ( - ) was synthesized and examined for their cytotoxicity to HepG2, MCF-7, and Caco-2 in an MTT assay. Among these…”
Get full text

Amelioration effect of Egyptian sweet orange hesperidin on Ehrlich ascites carcinoma (EAC) bearing mice by Donia, Thoria I.K., Gerges, Maria N., Mohamed, Tarek M.

“…There are global increased interests to identify novel agents that can possess anti-tumor effects or maximize the anti-tumor effects of low doses for…”
Get full text

The nephroprotective effects of allicin and ascorbic acid against cisplatin-induced toxicity in rats by Abdel-Daim, Mohamed M., Abushouk, Abdelrahman Ibrahim, Donia, Thoria, Alarifi, Saud, Alkahtani, Saad, Aleya, Lotfi, Bungau, Simona G.

“…Cisplatin (CDDP) may induce nephrotoxicity through oxidative stress, DNA damage, and inflammation. This study was performed to evaluate the antioxidant and…”
Get full text

β-Arrestin inhibition induces autophagy, apoptosis, G0/G1 cell cycle arrest in agonist-activated V2R receptor in breast cancer cells by Donia, Thoria, Abouda, Mohamed, Kelany, Mohamed, Hessien, Mohamed

“…Non-visual arrestins (β-arrestins) are endocytic proteins that mediate agonist-activated GPCRs internalization and signaling pathways in an independent manner…”
Get full text

Mechanistic-Based Classification of Endocytosis-Related Inhibitors: Does It Aid in Assigning Drugs against SARS-CoV-2? by Hessien, Mohamed, Donia, Thoria, Tabll, Ashraf A, Adly, Eiman, Abdelhafez, Tawfeek H, Attia, Amany, Alkafaas, Samar Sami, Kuna, Lucija, Glasnovic, Marija, Cosic, Vesna, Smolic, Robert, Smolic, Martina

“…Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) canonically utilizes clathrin-mediated endocytosis (CME) and several other endocytic mechanisms to…”
Get full text

Correction to: Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts by Diab, Thoria A., Donia, Thoria, Saad-Allah, Khalil M.

“…An amendment to this paper has been published and can be accessed via the original article…”
Get full text

Growth inhibition of human non-small lung cancer cells h460 by green tea and ginger polyphenols by Hessien, Mohamed, El-Gendy, Saad, Donia, Thoria, Sikkena, Morsy Abou

“…Non small cell lung cancer is known to resist apoptotic stimuli of various antitumor agents and become progressively incurable. The present study was…”
Get more information

Characterization, antioxidant, and cytotoxic effects of some Egyptian wild plant extracts by Diab, Thoria A., Donia, Thoria, Saad-Allah, Khalil M.

“…Background Natural products from plants are very safe as compared to synthetic ones, so the aim of this study was to assess the in vitro antioxidant and…”
Get full text

Anticancer Effects of Combination of Indole-3-Carbinol and Hydroxychloroquine on Ehrlich Ascites Carcinoma via Targeting Autophagy and Apoptosis by Donia, Thoria, Gerges, Marian N, Mohamed, Tarek M

“…Indole-3-carbinol (I3C) is an active component of cruciferous vegetables which is considered a promising antineoplastic agent. This study aimed to assess I3C…”
Get full text

Phosphorylation-dependent Akt-Inversin interaction at the basal body of primary cilia by Suizu, Futoshi, Hirata, Noriyuki, Kimura, Kohki, Edamura, Tatsuma, Tanaka, Tsutomu, Ishigaki, Satoko, Donia, Thoria, Noguchi, Hiroko, Iwanaga, Toshihiko, Noguchi, Masayuki

“…A primary cilium is a microtubule‐based sensory organelle that plays an important role in human development and disease. However, regulation of Akt in cilia…”
Get full text

Synergistic anticancer efficacy of polydatin and sorafenib against the MCF-7 breast cancer cell line via inhibiting of PI3K/AKT/mTOR pathway and reducing resistance to treatment by Donia, Thoria, Ali, Ehab M.M., Kalantan, Abdulaziz A., Alzahrani, Faisal Ay, Eid, Thamir M., Khamis, Abeer A.

“…Polydatin (PD), a glucoside derivative of resveratrol, has been investigated for its potential to mitigate sorafenib (SOF) side effects and combat multidrug…”
Get full text

Synthesis, X-ray, Hirshfeld combined with DFT, anticancer effects with molecular docking confirmation of (E)-4-cyanobenzaldehyde oxime and (Z)–N-methyl-C-4-substituted phenyl aldonitrones by Lasri, Jamal, Soliman, Saied M., Ali, Ehab M.M., Eltayeb, Naser E., Dege, Necmi, Donia, Thoria, Khamis, Abeer A., Alzahrani, Faisal Ay

“…•New aldoxime and aldonitrones were synthesized and fully characterised.•The X-ray structure of single crystal approved the 3D structure of the studied…”
Get full text

Functional characterization of lysosomal interaction of Akt with VRK2 by Hirata, Noriyuki, Suizu, Futoshi, Matsuda-Lennikov, Mami, Tanaka, Tsutomu, Edamura, Tatsuma, Ishigaki, Satoko, Donia, Thoria, Lithanatudom, Pathrapol, Obuse, Chikashi, Iwanaga, Toshihiko, Noguchi, Masayuki

“…Serine–threonine kinase Akt (also known as PKB, protein kinase B), a core intracellular mediator of cell survival, is involved in various human cancers and has…”
Get full text

Comparative study on the toxic effects of some heavy metals on the Nile Tilapia, Oreochromis niloticus, in the Middle Delta, Egypt by Alm-Eldeen, Abeer A., Donia, Thoria, Alzahaby, Salma

“…Heavy metals are the most dangerous hazards affecting aquatic biota in Egypt specially the Nile Tilapia, Oreochromis niloticus , which is an important species…”
Get full text

Propolis Potentiates Methotrexate Anticancer Mechanism and Reduces its Toxic Effects by Salem, Maha M., Donia, Thoria, Abu-Khudir, Rasha, Ramadan, Haitham, Ali, Ehab M. M., Mohamed, Tarek M.

“…Egyptian propolis is a powerful antioxidant and free radical scavenger produced by bees. The current study was designed to characterize Egyptian propolis,…”
Get full text

Evaluation of MicroRNA92, MicroRNA638 in Acute Lymphoblastic Leukemia of Egyptian Children by Fayed, Dina, Donia, Thoria, El-Shanshory, Mohamed, Ali, Ehab M M, Mohamed, Tarek M

Get full text

Identification of RNA aptamer which specifically interacts with PtdIns(3)P by Donia, Thoria, Jyoti, Bala, Suizu, Futoshi, Hirata, Noriyuki, Tanaka, Tsutomu, Ishigaki, Satoko, F, Pranzatelli Thomas J., Nio-Kobayashi, Junko, Iwanaga, Toshihiko, Chiorini, John A., Noguchi, Masayuki

“…The phosphinositide PtdIns(3)P plays an important role in autophagy; however, the detailed mechanism of its activity remains unclear. Here, we used a…”
Get full text

Managing GSH elevation and hypoxia to overcome resistance of cancer therapies using functionalized nanocarriers by Dabbour, Nelly M., Salama, Ahmed M., Donia, Thoria, Al-Deeb, Radwa T., Abd Elghane, Abdullah M., Badry, Karima H., Loutfy, Samah A.

“…Cancer is a fatal disease that is responsible for approximately 10 million deaths per year. This is due to complex mechanisms inside tumor microenvironment…”
Get full text

Ameliorating oxidative stress and inflammation by Hesperidin and vitamin E in doxorubicin induced cardiomyopathy by Donia, Thoria, Eldaly, Samar, Ali, Ehab M.M.

Get full text