Search Results - "Donghi, Monica"

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection by Summa, Vincenzo, Petrocchi, Alessia, Bonelli, Fabio, Crescenzi, Benedetta, Donghi, Monica, Ferrara, Marco, Fiore, Fabrizio, Gardelli, Cristina, Gonzalez Paz, Odalys, Hazuda, Daria J, Jones, Philip, Kinzel, Olaf, Laufer, Ralph, Monteagudo, Edith, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Pace, Paola, Pescatore, Giovanna, Scarpelli, Rita, Stillmock, Kara, Witmer, Marc V, Rowley, Michael

“…Human immunodeficiency virus type-1 (HIV-1) integrase is one of the three virally encoded enzymes required for replication and therefore a rational target for…”
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A Combinatorial Approach to Polyketide-Type Libraries by Iterative Asymmetric Aldol Reactions Performed on Solid Support by Paterson, Ian, Donghi, Monica, Gerlach, Kai

“…Solid‐phase synthesis of polyketide‐type sequences, such as 1, can be achieved efficiently by iterative, boron‐mediated, aldol reactions of chiral ketones 2…”
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Synthesis of a hexahydropyrimido[1,2- a]azepine-2-carboxamide derivative useful as an HIV integrase inhibitor by Ferrara, Marco, Crescenzi, Benedetta, Donghi, Monica, Muraglia, Ester, Nizi, Emanuela, Pesci, Silvia, Summa, Vincenzo, Gardelli, Cristina

“…The hexahydropyrimido[1,2- a]azepine-2-carboxamide derivative 1 could be obtained by three synthetic strategies, which allowed access to multigram amounts of…”
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3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates-A new class of HIV-1 integrase inhibitors by DONGHI, Monica, KINZEL, Olaf D, SUMMA, Vincenzo

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Taxol Semisynthesis:  A Highly Enantio- and Diastereoselective Synthesis of the Side Chain and a New Method for Ester Formation at C-13 Using Thioesters by Gennari, Cesare, Carcano, Michela, Donghi, Monica, Mongelli, Nicola, Vanotti, Ermes, Vulpetti, Anna

“…A very simple, new, and straightforward approach to the Paclitaxel (Taxol) and Docetaxel (Taxotere) side chains has been developed using the imine addition…”
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3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors by Donghi, Monica, Kinzel, Olaf D, Summa, Vincenzo

“…A new class of inhibitors of HIV-1 integrase has been optimized to provide selective and highly efficient strand transfer inhibition…”
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Phosphoramidate Prodrugs of 2′-C-Methylcytidine for Therapy of Hepatitis C Virus Infection by Gardelli, Cristina, Attenni, Barbara, Donghi, Monica, Meppen, Malte, Pacini, Barbara, Harper, Steven, Di Marco, Annalise, Fiore, Fabrizio, Giuliano, Claudio, Pucci, Vincenzo, Laufer, Ralph, Gennari, Nadia, Marcucci, Isabella, Leone, Joseph F, Olsen, David B, MacCoss, Malcolm, Rowley, Michael, Narjes, Frank

“…The application of a phosphoramidate prodrug approach to 2′-C-methylcytidine (NM107), the first nucleoside inhibitor of the hepatitis C virus (HCV) NS5B…”
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3-Hydroxy-4-oxo-4 H-pyrido[1,2- a]pyrimidine-2-carboxylates—A new class of HIV-1 integrase inhibitors by Donghi, Monica, Kinzel, Olaf D., Summa, Vincenzo

“…The synthesis and SAR of a new class of HIV-1 integrase inhibitors is reported. A new class of inhibitors of HIV-1 integrase has been optimized to provide…”
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Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates by Malancona, Savina, Donghi, Monica, Ferrara, Marco, Martin Hernando, Josè I., Pompei, Marco, Pesci, Silvia, Ontoria, Jesus M., Koch, Uwe, Rowley, Michael, Summa, Vincenzo

“…Chronic hepatitis C virus (HCV) infections are a significant medical problem worldwide. The NS5B Polymerase of HCV plays a central role in virus replication…”
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Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors by Muraglia, Ester, Kinzel, Olaf, Gardelli, Cristina, Crescenzi, Benedetta, Donghi, Monica, Ferrara, Marco, Nizi, Emanuela, Orvieto, Federica, Pescatore, Giovanna, Laufer, Ralph, Gonzalez-Paz, Odalys, Di Marco, Annalise, Fiore, Fabrizio, Monteagudo, Edith, Fonsi, Massimiliano, Felock, Peter J, Rowley, Michael, Summa, Vincenzo

“…HIV integrase is one of the three enzymes encoded by HIV genome and is essential for viral replication, but integrase inhibitors as marketed drugs have just…”
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Synthesis and evaluation of novel phosphoramidate prodrugs of 2′-methyl cytidine as inhibitors of hepatitis c virus NS5B polymerase by Donghi, Monica, Attenni, Barbara, Gardelli, Cristina, Marco, Annalise Di, Fiore, Fabrizio, Giuliano, Claudio, Laufer, Ralph, Leone, Joseph F., Pucci, Vincenzo, Rowley, Michael, Narjes, Frank

“…The synthesis and SAR of phosphoramidate prodrugs of 2′-methyl cytidine as inhibitors of HCV NS5B polymerase is reported. A variety of new prodrugs of…”
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3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates—fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors by Kinzel, Olaf D., Ball, Richard G., Donghi, Monica, Maguire, Courtney K., Muraglia, Ester, Pesci, Silvia, Rowley, Michael, Summa, Vincenzo

“…An efficient and reliable synthesis of the heterocyclic scaffold methyl- 3-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate is described. The scope of…”
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Inhibitors of the Hepatitis C Virus NS3 Protease with Basic Amine Functionality at the P3-Amino Acid N-Terminus: Discovery and Optimization of a New Series of P2−P4 Macrocycles by Harper, Steven, Ferrara, Marco, Crescenzi, Benedetta, Pompei, Marco, Palumbi, Maria Cecilia, DiMuzio, Jillian M, Donghi, Monica, Fiore, Fabrizio, Koch, Uwe, Liverton, Nigel J, Pesci, Silvia, Petrocchi, Alessia, Rowley, Michael, Summa, Vincenzo, Gardelli, Cristina

“…In a follow-up to our recent disclosure of P2−P4 macrocyclic inhibitors of the hepatitis C virus (HCV) NS3 protease (e.g., 1, Chart 1), we report a new but…”
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3-Hydroxy-4-oxo-4 H-pyrido[1,2- a]pyrimidine-2-carboxylates—fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors by Kinzel, Olaf D., Ball, Richard G., Donghi, Monica, Maguire, Courtney K., Muraglia, Ester, Pesci, Silvia, Rowley, Michael, Summa, Vincenzo

“…An efficient and reliable synthesis of the heterocyclic scaffold methyl-3-hydroxy-4-oxo-4 H-pyrido[1,2- a]pyrimidine-2-carboxylate is described. The scope of…”
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Structure-based design of amidinophenylurea-derivatives for factor VIIa inhibition by KLINGLER, Otmar, MATTER, Hans, SCHUDOK, Manfred, DONGHI, Monica, CZECH, Joerg, LORENZ, Martin, NESTLER, Hans Peter, SZILLAT, Hauke, SCHREUDER, Herman

“…The amidinophenylurea scaffold was earlier shown to provide an excellent template for the synthesis of novel and potent inhibitors of the blood coagulation…”
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Stereocontrolled synthesis of polyketide libraries: Boron-mediated aldol reactions with aldehydes on solid support by Gennari, Cesare, Ceccarelli, Simona, Piarulli, Umberto, Aboutayab, Karim, Donghi, Monica, Paterson, Ian

“…Two complementary classes of chiral boron enolates for adaptation to aldol additions to resin-bound aldehydes were studied: ( i) the thioester-derived enolate…”
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A Combinatorial Approach to Polyketide-Type Libraries by Iterative Asymmetric Aldol Reactions Performed on Solid Support by Paterson, Ian, Donghi, Monica, Gerlach, Kai

“…Die Festphasensynthese von Polyketidsequenzen vom Typ 1 gelang durch iterative, Bor‐vermittelte Aldolreaktionen des chiralen Ketons 2 mit dem auf einem…”
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