Search Results - "Dong, Zhiwan"

Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients by Subrahmanyam, Priyanka B, Dong, Zhiwan, Gusenleitner, Daniel, Giobbie-Hurder, Anita, Severgnini, Mariano, Zhou, Jun, Manos, Michael, Eastman, Lauren M, Maecker, Holden T, Hodi, F Stephen

“…While immune checkpoint blockade has greatly improved clinical outcomes in diseases such as melanoma, there remains a need for predictive biomarkers to…”
Get full text

Leukemia-Associated Rho Guanine Nucleotide Exchange Factor and Ras Homolog Family Member C Play a Role in Glioblastoma Cell Invasion and Resistance by Ding, Zonghui, Dong, Zhiwan, Yang, Yuping, Fortin Ensign, Shannon P., Sabit, Hemragul, Nakada, Mitsutoshi, Ruggieri, Rosamaria, Kloss, Jean M., Symons, Marc, Tran, Nhan L., Loftus, Joseph C.

“…Glioblastoma (GBM) is the most common primary malignant brain cancer in adults. A hallmark of GBM is aggressive invasion of tumor cells into the surrounding…”
Get full text

Pretreatment serum VEGF is associated with clinical response and overall survival in advanced melanoma patients treated with ipilimumab by Yuan, Jianda, Zhou, Jun, Dong, Zhiwan, Tandon, Sapna, Kuk, Deborah, Panageas, Katherine S, Wong, Philip, Wu, Xinqi, Naidoo, Jarushka, Page, David B, Wolchok, Jedd D, Hodi, F Stephen

“…Ipilimumab, an antibody that blocks CTL antigen 4 (CTLA-4), improves overall survival (OS) for patients with metastatic melanoma. Given its role in…”
Get more information

Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair by Leppard, John B., Dong, Zhiwan, Mackey, Zachary B., Tomkinson, Alan E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Nijmegen Breakage Syndrome Protein Is Essential for Mre11 Phosphorylation upon DNA Damage by Dong, Z, Zhong, Q, Chen, P L

“…The Nijmegen breakage syndrome (NBS), a chromosomal instability disorder, is characterized in part by cellular hypersensitivity to ionizing radiation. Repair…”
Get full text

A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling by McArthur, Heather L, Diab, Adi, Page, David B, Yuan, Jianda, Solomon, Stephen B, Sacchini, Virgilio, Comstock, Christopher, Durack, Jeremy C, Maybody, Majid, Sung, Janice, Ginsberg, Arielle, Wong, Phillip, Barlas, Afsar, Dong, Zhiwan, Zhao, Chunjun, Blum, Brian, Patil, Sujata, Neville, Deirdre, Comen, Elizabeth A, Morris, Elizabeth A, Kotin, Alan, Brogi, Edi, Wen, Y Hannah, Morrow, Monica, Lacouture, Mario E, Sharma, Padmanee, Allison, James P, Hudis, Clifford A, Wolchok, Jedd D, Norton, Larry

“…To assess the safety and tolerability of preoperative cryoablation-mediated tumor antigen presentation and/or ipilimumab-mediated immune modulation in women…”
Get full text

Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma by Postow, Michael A, Manuel, Manuarii, Wong, Phillip, Yuan, Jianda, Dong, Zhiwan, Liu, Cailian, Perez, Solène, Tanneau, Isabelle, Noel, Marlène, Courtier, Anaïs, Pasqual, Nicolas, Wolchok, Jedd D

“…Ipilimumab improves overall survival in a subset of patients with metastatic melanoma. Peripheral blood T cell receptor (TCR) repertoire diversity has been…”
Get full text

Phase 1/2 study of epacadostat in combination with durvalumab in patients with metastatic solid tumors by Naing, Aung, Algazi, Alain P., Falchook, Gerald S., Creelan, Benjamin C., Powderly, John, Rosen, Seth, Barve, Minal, Mettu, Niharika B., Triozzi, Pierre L., Hamm, John, Zhou, Gongfu, Walker, Chris, Dong, Zhiwan, Patel, Manish R.

“…BACKGROUND Targeting programmed cell death protein 1 (PD‐1) and indoleamine 2,3‐dioxygenase (IDO1) pathways is an appealing option for cancer treatment…”
Get full text

Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy by Page, David B, Yuan, Jianda, Redmond, David, Wen, Y Hanna, Durack, Jeremy C, Emerson, Ryan, Solomon, Stephen, Dong, Zhiwan, Wong, Phillip, Comstock, Christopher, Diab, Adi, Sung, Janice, Maybody, Majid, Morris, Elizabeth, Brogi, Edi, Morrow, Monica, Sacchini, Virgilio, Elemento, Olivier, Robins, Harlan, Patil, Sujata, Allison, James P, Wolchok, Jedd D, Hudis, Clifford, Norton, Larry, McArthur, Heather L

“…In early-stage breast cancer, the degree of tumor-infiltrating lymphocytes (TIL) predicts response to chemotherapy and overall survival. Combination…”
Get more information

677 A phase 2, open-label, multicenter study of INCAGN01876 (anti-GITR agonist) in combination with retifanlimab (anti–PD-1) in recurrent or metastatic head and neck squamous cell carcinoma by Leidner, Rom, Haddad, Robert, Bourayou, Nawel, Ioannidis, Sonia, Zhou, Feng, Dong, Zhiwan, Cohen, Ezra

“…BackgroundAlthough anti–programmed cell death (PD)-ligand (L)1 therapies have improved clinical outcomes in patients with PD-L1+ recurrent or metastatic head…”
Get full text

Cell-of-Origin Subtype Prediction of Diffuse Large B-Cell Lymphoma Using Gene Expression and Proteomic Data by Liu, Huiqing, Lu, Jin, Dong, Zhiwan, Liu, Hao, Salinas, Edward, Owens, Sherry, Pratta, Michael A., Smith, Michael F., Tada, Hiroomi, Newton, Robert C, Burn, Timothy

“…Introduction Diffuse large B-cell lymphoma (DLBCL) subtypes can be identified based on immunohistochemistry, somatic mutation and gene expression profiles…”
Get full text

The MLK-related Kinase (MRK) Is a Novel RhoC Effector That Mediates Lysophosphatidic Acid (LPA)-stimulated Tumor Cell Invasion by Korkina, Olga, Dong, Zhiwan, Marullo, Allison, Warshaw, Gregg, Symons, Marc, Ruggieri, Rosamaria

“…The small GTPase RhoC is overexpressed in many invasive tumors and is essential for metastasis. Despite its high structural homology to RhoA, RhoC appears to…”
Get full text

ANGI-02. A CRITICAL ROLE FOR LARG IN RhoC MEDIATED GLIOBLASTOMA CELL INVASION by Ding, Zonghui, Dong, Zhiwan, Yang, Yuping, Fortin-Ensign, Shannon, Sabit, Hemragul, Nakada, Mitsutoshi, Ruggieri, Rosamaria, Symons, Marc, Tran, Nhan, Loftus, Joseph

“…Abstract Glioblastoma (GBM) is the most common and highly lethal central nervous tumor in adults. A significant hurdle to effective clinical treatment is the…”
Get full text

CB-11DIVERSE ROLES FOR RhoA AND RhoC IN GLIOBLASTOMA by Kwiatkowska, Aneta, Paulino, Vincent, Dong, Zhiwan, Loftus, Joseph, Kloss, Jean, Ruggieri, Rosamaria, Tran, Nhan, Symons, Marc

“…A number of Rho family members have been shown to control tumor cell proliferation, survival and invasion. Rhophilin, an effector of both RhoA and RhoC, is…”
Get full text

Role of a DNA Damage Checkpoint Pathway in Ionizing Radiation-Induced Glioblastoma Cell Migration and Invasion by Vanan, Issai, Dong, Zhiwan, Tosti, Elena, Warshaw, Gregg, Symons, Marc, Ruggieri, Rosamaria

“…Ionizing radiation (IR) induces a DNA damage response that includes activation of cell cycle checkpoints, leading to cell cycle arrest. In addition, IR…”
Get full text

Abstract LB-516: PDZ-RhoGEF promotes glioblastoma cell invasion, proliferation and survival by Kwiatkowska, Aneta, Dong, Zhiwan, Paulino, Vincent M., Tran, Nhan L., Ruggieri, Rosamaria, Symons, Marc H.

“…Abstract Invasion of glioblastoma cells into the surrounding brain parenchyma is a critical parameter of this disease as it hampers complete surgical resection…”
Get full text

ATM mediates oxidative stress-induced dephosphorylation of DNA ligase III[alpha] by Dong, Zhiwan, Tomkinson, Alan E

“…Among the three mammalian genes encoding DNA ligases, only the LIG3 gene does not have a homolog in lower eukaryotes. In somatic mammalian cells, the nuclear…”
Get full text

Abstract P2-15-01: Integrated immunologic assessment of tumor infiltrating lymphocytes (TILs) and peripheral blood to assess synergy of cryoablation (cryo) plus ipilimumab (ipi) in early stage breast cancer (ESBC) patients (pts) by Page, David, Yuan, Jianda, Diab, Adi, Dong, Zhiwan, Ginsberg, Arielle, Wong, Phillip, Emerson, Ryan, Redmond, David, Blum, Brian, Mu, Zhenyu, Zhao, Chunjun, Comstock, Christopher, Morris, Elizabeth, Comen, Elizabeth, Kotin, Alan, Sung, Janice, Brogi, Edi, Morrow, Monica, Solomon, Stephen, Sacchini, Virgilio, Maybody, Majid, Neville, Deirdre, Robins, Harlan, Patil, Sujata, Wolchok, Jedd, Hudis, Clifford, Norton, Larry, Allison, James, Sharma, Padmanee, McArthur, Heather

“…Abstract Background: In pts with ESBC, cryo combined with cytotoxic T-lymphocyte antigen 4 blockade was well tolerated and did not delay standard-of-care…”
Get full text

ATM mediates oxidative stress-induced dephosphorylation of DNA ligase IIIα by Dong, Zhiwan, Tomkinson, Alan E.

“…Among the three mammalian genes encoding DNA ligases, only the LIG3 gene does not have a homolog in lower eukaryotes. In somatic mammalian cells, the nuclear…”
Get full text

Tumor and systemic immune responses to preoperative (pre-op) cryoablation (cryo) plus immune therapy with ipilimumab (ipi) in early-stage breast cancer (ESBC) by Page, David B., Yuan, Jianda, Ginsberg, Arielle, Dong, Zhiwan, Wong, Phillip, Emerson, Ryan, Sung, Janice S., Comstock, Christopher, Solomon, Stephen Barnett, Sacchini, Virgilio, Morrow, Monica, Brogi, Edi, Morris, Elizabeth Ann, Patil, Sujata, Robins, Harlan, Wolchok, Jedd D., Hudis, Clifford A., Norton, Larry, Allison, James Patrick, McArthur, Heather L.

“…Abstract only 64 Background: In mice, tumor cryo plus immunologic checkpoint blockade generates tumor antigen release, proliferation of tumor-specific T-cells,…”
Get full text