Search Results - "Dong, Zhiqian"

In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration by Choi, Elliot H., Suh, Susie, Foik, Andrzej T., Leinonen, Henri, Newby, Gregory A., Gao, Xin D., Banskota, Samagya, Hoang, Thanh, Du, Samuel W., Dong, Zhiqian, Raguram, Aditya, Kohli, Sajeev, Blackshaw, Seth, Lyon, David C., Liu, David R., Palczewski, Krzysztof

“…Leber congenital amaurosis (LCA) is the most common cause of inherited retinal degeneration in children. LCA patients with RPE65 mutations show accelerated…”
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Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing by Suh, Susie, Choi, Elliot H., Leinonen, Henri, Foik, Andrzej T., Newby, Gregory A., Yeh, Wei-Hsi, Dong, Zhiqian, Kiser, Philip D., Lyon, David C., Liu, David R., Palczewski, Krzysztof

“…Cytosine base editors and adenine base editors (ABEs) can correct point mutations predictably and independent of Cas9-induced double-stranded DNA breaks (which…”
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Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye by Palczewska, Grazyna, Dong, Zhiqian, Golczak, Marcin, Hunter, Jennifer J, Williams, David R, Alexander, Nathan S, Palczewski, Krzysztof

“…Repetitive dynamic two-photon imaging of retinoid cycle fluorophores and subcellular details of their location within the retinal pigment epithelium in intact…”
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Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice by Maeda, Akiko, Palczewska, Grazyna, Golczak, Marcin, Kohno, Hideo, Dong, Zhiqian, Maeda, Tadao, Palczewski, Krzysztof

“…Atrophic age-related and juvenile macular degeneration are especially devastating due to lack of an effective cure. Two retinal cell types, photoreceptor cells…”
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Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition by Sander, Christopher L, Sears, Avery E, Pinto, Antonio F M, Choi, Elliot H, Kahremany, Shirin, Gao, Fangyuan, Salom, David, Jin, Hui, Pardon, Els, Suh, Susie, Dong, Zhiqian, Steyaert, Jan, Saghatelian, Alan, Skowronska-Krawczyk, Dorota, Kiser, Philip D, Palczewski, Krzysztof

“…Photoreceptors rely on distinct membrane compartments to support their specialized function. Unlike protein localization, identification of critical…”
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Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia by Tworak, Aleksander, Kolesnikov, Alexander V., Hong, John D., Choi, Elliot H., Luu, Jennings C., Palczewska, Grazyna, Dong, Zhiqian, Lewandowski, Dominik, Brooks, Matthew J., Campello, Laura, Swaroop, Anand, Kiser, Philip D., Kefalov, Vladimir J., Palczewski, Krzysztof

“…In daylight, demand for visual chromophore (11-cis-retinal) exceeds supply by the classical visual cycle. This shortfall is compensated, in part, by the…”
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A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models by Leinonen, Henri, Zhang, Jianye, Occelli, Laurence M., Seemab, Umair, Choi, Elliot H., L.P. Marinho, Luis Felipe, Querubin, Janice, Kolesnikov, Alexander V., Galinska, Anna, Kordecka, Katarzyna, Hoang, Thanh, Lewandowski, Dominik, Lee, Timothy T., Einstein, Elliott E., Einstein, David E., Dong, Zhiqian, Kiser, Philip D., Blackshaw, Seth, Kefalov, Vladimir J., Tabaka, Marcin, Foik, Andrzej, Petersen-Jones, Simon M., Palczewski, Krzysztof

“…Inherited retinopathies are devastating diseases that in most cases lack treatment options. Disease-modifying therapies that mitigate pathophysiology…”
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A novel human disease with abnormal prion protein sensitive to protease by Gambetti, Pierluigi, Dong, Zhiqian, Yuan, Jue, Xiao, Xiangzhu, Zheng, Mengjie, Alshekhlee, Amer, Castellani, Rudy, Cohen, Mark, Barria, Marcelo A., Gonzalez-Romero, D., Belay, Ermias D., Schonberger, Lawrence B., Marder, Karen, Harris, Carrie, Burke, James R., Montine, Thomas, Wisniewski, Thomas, Dickson, Dennis W., Soto, Claudio, Hulette, Christine M., Mastrianni, James A., Kong, Qingzhong, Zou, Wen-Quan

“…Objective To report a novel prion disease characterized by distinct histopathological and immunostaining features, and associated with an abnormal isoform of…”
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MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice by Sundermeier, Thomas R, Sakami, Sanae, Sahu, Bhubanananda, Howell, Scott J, Gao, Songqi, Dong, Zhiqian, Golczak, Marcin, Maeda, Akiko, Palczewski, Krzysztof

“…Age-related macular degeneration (AMD) is a major cause of irreversible vision loss. The neovascular or "wet" form of AMD can be treated to varying degrees…”
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Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration by Chen, Yu, Palczewska, Grazyna, Masuho, Ikuo, Gao, Songqi, Jin, Hui, Dong, Zhiqian, Gieser, Linn, Brooks, Matthew J, Kiser, Philip D, Kern, Timothy S, Martemyanov, Kirill A, Swaroop, Anand, Palczewski, Krzysztof

“…Photoreceptor cell degeneration leads to visual impairment and blindness in several types of retinal disease. However, the discovery of safe and effective…”
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Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors by Kolesnikov, Alexander V., Orban, Tivadar, Jin, Hui, Brooks, Celine, Hofmann, Lukas, Dong, Zhiqian, Sokolov, Maxim, Palczewski, Krzysztof, Kefalov, Vladimir J.

“…Resetting of G-protein–coupled receptors (GPCRs) from their active state back to their biologically inert ground state is an integral part of GPCR signaling…”
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An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease by Choi, Elliot H, Suh, Susie, Einstein, David E, Leinonen, Henri, Dong, Zhiqian, Rao, Sriganesh Ramachandra, Fliesler, Steven J, Blackshaw, Seth, Yu, Minzhong, Peachey, Neal S, Palczewski, Krzysztof, Kiser, Philip D

“…The retinal pigment epithelium (RPE) provides vital metabolic support for retinal photoreceptor cells and is an important player in numerous retinal diseases…”
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Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision by Lewandowski, Dominik, Foik, Andrzej T, Smidak, Roman, Choi, Elliot H, Zhang, Jianye, Hoang, Thanh, Tworak, Aleksander, Suh, Susie, Leinonen, Henri, Dong, Zhiqian, Pinto, Antonio Fm, Tom, Emily, Luu, Jennings, Lee, Joan, Ma, Xiuli, Bieberich, Erhard, Blackshaw, Seth, Saghatelian, Alan, Lyon, David C, Skowronska-Krawczyk, Dorota, Tabaka, Marcin, Palczewski, Krzysztof

“…Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that possesses intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have…”
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Insoluble Aggregates and Protease-resistant Conformers of Prion Protein in Uninfected Human Brains by Yuan, Jue, Xiao, Xiangzhu, McGeehan, John, Dong, Zhiqian, Cali, Ignazio, Fujioka, Hisashi, Kong, Qingzhong, Kneale, Geoff, Gambetti, Pierluigi, Zou, Wen-Quan

“…Aggregated prion protein (PrPSc), which is detergent-insoluble and partially proteinase K (PK)-resistant, constitutes the major component of infectious prions…”
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Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing by Suh, Susie, Choi, Elliot H., Leinonen, Henri, Foik, Andrzej T., Newby, Gregory A., Yeh, Wei-Hsi, Dong, Zhiqian, Kiser, Philip D., Lyon, David C., Liu, David R., Palczewski, Krzysztof

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Failure to Detect the Presence of Prions in the Uterine and Gestational Tissues from a Gravida with Creutzfeldt-Jakob Disease by Xiao, Xiangzhu, Miravalle, Leticia, Yuan, Jue, McGeehan, John, Dong, Zhiqian, Wyza, Robert, MacLennan, Gregory T, Golichowski, Alan M, Kneale, Geoff, King, Nicholas, Kong, Qingzhong, Spina, Salvatore, Vidal, Ruben, Ghetti, Bernardino, Roos, Karen, Gambetti, Pierluigi, Zou, Wen-Quan

“…The vertical transmission of a prion disease from infected mothers to their offspring is believed to be one of the routes for the natural spread of animal…”
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Creutzfeldt-Jakob Disease (CJD) with a Mutation at Codon 148 of Prion Protein Gene: Relationship with Sporadic CJD by Pastore, Manuela, Chin, Steven S, Bell, Karen L, Dong, Zhiqian, Yang, Qiwei, Yang, Lizhu, Yuan, Jue, Chen, Shu G, Gambetti, Pierluigi, Zou, Wen-Quan

“…Creutzfeldt-Jakob disease (CJD), the most common human prion disease, includes sporadic (s) and familial (f) forms. Regardless of etiology, both forms are…”
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A real‐time seismic damage prediction framework based on machine learning for earthquake early warning by Zhang, Hui, Yu, Dinghao, Li, Gang, Dong, Zhiqian

“…For implementing earthquake early warning (EEW), real‐time parameters of ground motion (GM) which can be obtained at the beginning of earthquake wave arrival…”
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A mixed stochastic waves model for analyzing offshore structures considering engineering characteristics correlation of wind-generated-wave and swell by Li, Gang, Jiang, Yunmu, Yu, Dinghao, Dong, Zhiqian

“…In the marine environment, offshore structures face mixed stochastic waves, including wind-generated waves and swells. Current design codes often overlook…”
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Simplified Collapse Analysis Model for RC Frames with Cyclic Deterioration Behaviors by Li, Gang, Yu, Liling, Dong, Zhiqian

“…Equivalent single-degree-of-freedom (ESDOF) models are widely used to evaluate the collapse capacity of multistory structures, and their rationality is very…”
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