Search Results - "Dong, Yongxi"

In vivo anti-hyperuricemia and anti-gouty arthritis effects of the ethanol extract from Amomumvillosum Lour by Dong, Li, Zhang, Shanhui, Chen, Lina, Lu, Jun, Zhao, Fuhui, Long, Tiemei, Wen, Jinlan, Huang, Jiayu, Mao, Yuanhu, Qi, Zhengfang, Zhang, Jiquan, Li, Lei, Dong, Yongxi

“…The incidence of hyperuricemia and gout has been increasing year by year, and it is showing a younger trend. However, the first-line drugs currently used for…”
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Hybrid molecules of scutellarein and 3, 5, 6-trimethylpyrazine-2-formic acid linked with polar amino acid for ischemic stroke by Wu, Shuxia, Liu, Mingji, Wen, Jinlan, Chen, Lina, Lu, Jun, Li, Lei, Yang, Yaxin, Dong, Yongxi, Dong, Li, Dong, Yongxi

“…Scutellarin has been found to possess a certain protective activity against oxidative damage, and scutellarein has been proved to be the main absorption…”
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Metabolomic Insights into the Mechanisms of Ganoderic Acid: Protection against α-Amanitin-Induced Liver Injury by Zheng, Chong, Lv, Shaofang, Ye, Jianfang, Zou, Lu, Zhu, Kai, Li, Haichang, Dong, Yongxi, Li, Lei

“…α-Amanitin is a representative toxin found in the Amanita genus of mushrooms, and the consumption of mushrooms containing α-Amanitin can lead to severe liver…”
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Conjugates of Tetramethylpyrazine’ metabolites and amino acid as potential antiplatelet agents by Dong, Yongxi, Wu, Shuxia, Liu, Mingji, Huang, Jiayu, Mao, Yuanhu, Zhang, Jiquan, Yang, Zhanzhan, Li, Lei, Liu, Gang, Liao, Shanggao, Dong, Li

“…Tetramethylpyrazine (TMP) is commonly used as an antiplatelet drug in clinic. However, the short half-life and low bioavailability limited its applications. 3,…”
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Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer by Sun, Qiwen, Chu, Yuxiu, Zhang, Nana, Chen, Rui, Wang, Lili, Wu, Jiangxia, Dong, Yongxi, Li, Hongliang, Wang, Ling, Tang, Lei, Zhan, Changyou, Zhang, Ji-Quan

“…The aberrant activation of the PI3K/mTOR signaling pathway is implicated in various human cancers. Thus, the development of inhibitors targeting mTOR has…”
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Hybrid molecules of scutellarein and tertramethylpyrazine’s active metabolites for ischemic stroke by Dong, Yongxi, Zhang, Xiaohe, Liu, Mingji, Yang, Yang, Guo, Ting, Mao, Yuanhu, Zhang, Jiquan, Fu, Xiaozhong, Zhao, Yonglong, Chen, Jinglei, Dong, Li, Qiao, Chunhua

“…[Display omitted] A series of hybrid molecules of scutellarein and tertramethylpyrazine’s active metabolites have been synthesized. Compared to the original…”
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Synthesis and bioevaluation of Scutellarein-Tertramethylpyrazine hybrid molecules for the treatment of ischemic stroke by Dong, Yongxi, Wang, Fang, Wen, Jinlan, Mao, Yongqing, Zhang, Shanhui, Long, Tiemei, Yang, Zhangxiang, Li, Lei, Zhang, Jiquan, Dong, Li, Liu, Gang, Xu, Jianwei

“…Ischemic stroke caused by insufficient blood supply to the brain may produce a sequence of cascade reactions, leading to oxidative stress and ultimately…”
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Design, synthesis and bioevaluation of 1,2,4-thiadiazolidine-3,5-dione derivatives as potential GSK-3β inhibitors for the treatment of Alzheimer's disease by Dong, Yongxi, Lu, Jun, Zhang, Shanhui, Chen, Lina, Wen, Jinlan, Wang, Fang, Mao, Yongqing, Li, Lei, Zhang, Jiquan, Liao, Shanggao, Dong, Li

“…[Display omitted] •The kinase inhibitory activity of the selected compound 10a with better neuroprotective effect was 2.7 fold than that of Tideglusib.•Similar…”
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Discovery of 2-(isoxazol-5-yl)phenyl 3,4-dihydroxybenzoate as a potential inhibitor for the Wnt/β-catenin pathway by Dong, Yongxi, Liu, Mingji, Mao, Yongqing, Wu, Shuxia, Wen, Jinlan, Lu, Jun, Yang, Yaxin, Ruan, Shiyang, Li, Lei, Liu, Xinyun, Zhang, Jiquan, Liao, Shanggao, Dong, Li

“…[Display omitted] •S11 showed strong proliferation inhibition effect and excellent selectivity index against Wnt hyperactive cancer cells.•S11 could obvioudsly…”
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Synthesis and biological evaluation of N-alkyl-1,4-dihydroquinoline prodrugs of scutellarin methyl ester as neuroprotective agents by Dong, Yongxi, Dong, Li, Chen, Jinglei, Luo, Min, Fu, Xiaozhong, Qiao, Chunhua

“…A series of N -alkyl-1,4-dihydroquinoline prodrugs of scutellarin methyl ester have been synthesized ( 4a–4f ). Compared to the parent compound scutellarin, we…”
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