Search Results - "Dong, Yiyu"

Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes by Ganly, Ian, Makarov, Vladimir, Deraje, Shyamprasad, Dong, YiYu, Reznik, Ed, Seshan, Venkatraman, Nanjangud, Gouri, Eng, Stephanie, Bose, Promita, Kuo, Fengshen, Morris, Luc G.T., Landa, Inigo, Carrillo Albornoz, Pedro Blecua, Riaz, Nadeem, Nikiforov, Yuri E., Patel, Kepal, Umbricht, Christopher, Zeiger, Martha, Kebebew, Electron, Sherman, Eric, Ghossein, Ronald, Fagin, James A., Chan, Timothy A.

“…The molecular foundations of Hürthle cell carcinoma (HCC) are poorly understood. Here we describe a comprehensive genomic characterization of 56 primary HCC…”
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Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy by Inoue-Yamauchi, Akane, Jeng, Paul S., Kim, Kwanghee, Chen, Hui-Chen, Han, Song, Ganesan, Yogesh Tengarai, Ishizawa, Kota, Jebiwott, Sylvia, Dong, Yiyu, Pietanza, Maria C., Hellmann, Matthew D., Kris, Mark G., Hsieh, James J., Cheng, Emily H.

“…BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we…”
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The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma by Nargund, Amrita M., Pham, Can G., Dong, Yiyu, Wang, Patricia I., Osmangeyoglu, Hatice U., Xie, Yuchen, Aras, Omer, Han, Song, Oyama, Toshinao, Takeda, Shugaku, Ray, Chelsea E., Dong, Zhenghong, Berge, Mathieu, Hakimi, A. Ari, Monette, Sebastien, Lekaye, Carl L., Koutcher, Jason A., Leslie, Christina S., Creighton, Chad J., Weinhold, Nils, Lee, William, Tickoo, Satish K., Wang, Zhong, Cheng, Emily H., Hsieh, James J.

“…PBRM1 is the second most commonly mutated gene after VHL in clear cell renal cell carcinoma (ccRCC). However, the biological consequences of PBRM1 mutations…”
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Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets by Chen, Ying-Bei, Xu, Jianing, Skanderup, Anders Jacobsen, Dong, Yiyu, Brannon, A. Rose, Wang, Lu, Won, Helen H., Wang, Patricia I., Nanjangud, Gouri J., Jungbluth, Achim A., Li, Wei, Ojeda, Virginia, Hakimi, A. Ari, Voss, Martin H., Schultz, Nikolaus, Motzer, Robert J., Russo, Paul, Cheng, Emily H., Giancotti, Filippo G., Lee, William, Berger, Michael F., Tickoo, Satish K., Reuter, Victor E., Hsieh, James J.

“…Renal cell carcinomas with unclassified histology (uRCC) constitute a significant portion of aggressive non-clear cell renal cell carcinomas that have no…”
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Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin by Xu, Jianing, Pham, Can G, Albanese, Steven K, Dong, Yiyu, Oyama, Toshinao, Lee, Chung-Han, Rodrik-Outmezguine, Vanessa, Yao, Zhan, Han, Song, Chen, David, Parton, Daniel L, Chodera, John D, Rosen, Neal, Cheng, Emily H, Hsieh, James J

“…Genomic studies have linked mTORC1 pathway-activating mutations with exceptional response to treatment with allosteric inhibitors of mTORC1 called rapalogs…”
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Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection by Sinha, Rileen, Winer, Andrew G., Chevinsky, Michael, Jakubowski, Christopher, Chen, Ying-Bei, Dong, Yiyu, Tickoo, Satish K., Reuter, Victor E., Russo, Paul, Coleman, Jonathan A., Sander, Chris, Hsieh, James J., Hakimi, A. Ari

“…The utility of cancer cell lines is affected by the similarity to endogenous tumour cells. Here we compare genomic data from 65 kidney-derived cell lines from…”
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Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts by Kim, Kwanghee, Hu, Wenhuo, Audenet, François, Almassi, Nima, Hanrahan, Aphrothiti J., Murray, Katie, Bagrodia, Aditya, Wong, Nathan, Clinton, Timothy N., Dason, Shawn, Mohan, Vishnu, Jebiwott, Sylvia, Nagar, Karan, Gao, Jianjiong, Penson, Alex, Hughes, Chris, Gordon, Benjamin, Chen, Ziyu, Dong, Yiyu, Watson, Philip A., Alvim, Ricardo, Elzein, Arijh, Gao, Sizhi P., Cocco, Emiliano, Santin, Alessandro D., Ostrovnaya, Irina, Hsieh, James J., Sagi, Irit, Pietzak, Eugene J., Hakimi, A. Ari, Rosenberg, Jonathan E., Iyer, Gopa, Vargas, Herbert A., Scaltriti, Maurizio, Al-Ahmadie, Hikmat, Solit, David B., Coleman, Jonathan A.

“…Treatment paradigms for patients with upper tract urothelial carcinoma (UTUC) are typically extrapolated from studies of bladder cancer despite their distinct…”
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ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival by Wang, Gary X., Tu, Ho-Chou, Dong, Yiyu, Skanderup, Anders Jacobsen, Wang, Yufeng, Takeda, Shugaku, Ganesan, Yogesh Tengarai, Han, Song, Liu, Han, Hsieh, James J., Cheng, Emily H.

“…The BCL-2 family proteins are central regulators of apoptosis. However, cells deficient for BAX and BAK or overexpressing BCL-2 still succumb to oxidative…”
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Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers by Wang, Jianbo, Day, Ryan, Dong, Yiyu, Weintraub, Steven J, Michel, Loren

“…The cell surface protein Trop-2 is highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult…”
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Synthetic Lethality through Combined Notch-Epidermal Growth Factor Receptor Pathway Inhibition in Basal-Like Breast Cancer by YIYU DONG, AIMIN LI, JIANBO WANG, WEBER, Jason D, MICHEL, Loren S

“…Basal-like breast cancers (BLBC) are highly aggressive, yet selective therapies targeting the specific oncoproteins driving these tumors have not been…”
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Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers by Malouf, Gabriel G., Flippot, Ronan, Dong, Yiyu, Dinatale, Renzo G., Chen, Ying-Bei, Su, Xiaoping, Compérat, Eva, Rouprêt, Morgan, Mano, Roy, Blum, Kyle A., Yao, Hui, Mouawad, Roger, Spano, Jean-Philippe, Khayat, David, Karam, Jose A., Ho, Thai H., Tickoo, Satish K., Russo, Paul, Hsieh, James J., Tannir, Nizar M., Hakimi, Abraham A.

“…Sarcomatoid clear-cell renal cell carcinomas (sRCC) are associated with dismal prognosis. Genomic alterations associated with sarcomatoid dedifferentiation are…”
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HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma by Takeda, Shugaku, Liu, Han, Sasagawa, Satoru, Dong, Yiyu, Trainor, Paul A, Cheng, Emily H, Hsieh, James J

“…HGF signals through its cognate receptor, MET, to orchestrate diverse biological processes, including cell proliferation, cell fate specification,…”
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PUMA and BIM are required for oncogene inactivation-induced apoptosis by Bean, Gregory R, Ganesan, Yogesh Tengarai, Dong, Yiyu, Takeda, Shugaku, Liu, Han, Chan, Po M, Huang, Yafen, Chodosh, Lewis A, Zambetti, Gerard P, Hsieh, James J-D, Cheng, Emily H-Y

“…The clinical efficacy of tyrosine kinase inhibitors supports the dependence of distinct subsets of cancers on specific driver mutations for survival, a…”
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A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth by CHEN, David Y, LEE, Yishan, OH, Kyoung J, KORSMEYER, Stanley J, HERMONE, Ann, GUSSIO, Richard, SHOEMAKER, Robert H, CHENG, Emily H.-Y, HSIEH, James J.-D, VAN TINE, Brian A, SEARLEMAN, Adam C, WESTERGARD, Todd D, HAN LIU, TU, Ho-Chou, TAKEDA, Shugaku, YIYU DONG, PIWNICA-WORMS, David R

“…The threonine endopeptidase Taspase1 has a critical role in cancer cell proliferation and apoptosis. In this study, we developed and evaluated small molecule…”
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Obtaining and analysis of flanking sequences from T-DNA transformants of Arabidopsis by Qin, Genji, Kang, Dingming, Dong, Yiyu, Shen, Yunping, Zhang, Li, Deng, Xiaohui, Zhang, Yao, Li, Song, Chen, Nan, Niu, Weiran, Chen, Cong, Liu, Peicheng, Chen, Haodong, Li, Jigang, Ren, Yanfei, Gu, Hongya, Deng, XingWang, Qu, Li-Jia, Chen, Zhangliang

“…Large collections of insertional Arabidopsis lines are valuable for research on functional genomics. Using the activation tagging vector pSKI015, more than 45…”
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A dual-modal PET/near infrared fluorescent nanotag for long-term immune cell tracking by Harmsen, Stefan, Medine, Emin Ilker, Moroz, Maxim, Nurili, Fuad, Lobo, Jose, Dong, Yiyu, Turkekul, Mezruh, Pillarsetty, Naga Vara Kishore, Ting, Richard, Ponomarev, Vladimir, Akin, Oguz, Aras, Omer

“…Adoptive cell transfer of targeted chimeric antigen receptor (CAR) T cells has emerged as a highly promising cancer therapy. The pharmacodynamic action or CAR…”
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Mathematical models of tumor growth using Voronoi tessellations in pathology slides of kidney cancer by Saribudak, Aydin, Yiyu Dong, Gundry, Stephen, Hsieh, James, Uyar, M. Umit

“…The impact of patient-specific spatial distribution features of cell nuclei on tumor growth characteristics was analyzed. Tumor tissues from kidney cancer…”
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Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models by Dong, Yiyu, Eskandari, Roozbeh, Ray, Chelsea, Granlund, Kristin L, Santos-Cunha, Lidia Dos, Miloushev, Vesselin Z, Tee, Sui Seng, Jeong, Sangmoo, Aras, Omer, Chen, Ying-Bei, Cheng, Emily H, Hsieh, James J, Keshari, Kayvan R

“…The ever-changing tumor microenvironment constantly challenges individual cancer cells to balance supply and demand, presenting tumor vulnerabilities and…”
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Targeting the mTOR Pathway in Hurthle Cell Carcinoma Results in Potent Anti-Tumor Activity by Dong, Yiyu, Gong, Yongxing, Kuo, Fengshen, Makarov, Vladimir, Reznik, Ed, Nanjangud, Gouri J., Aras, Omer, Zhao, Huiyong, Qu, Rui, Fagin, James A., Sherman, Eric J., Xu, Bin, Ghossein, Ronald, Chan, Timothy A., Ganly, Ian

“…Hurthle cell carcinomas (HCC) are refractory to radioactive iodine and unresponsive to chemotherapeutic agents, with a fatality rate that is the highest among…”
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SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes by Xie, Yuchen, Sahin, Merve, Sinha, Sonali, Wang, Yufeng, Nargund, Amrita M, Lyu, Yang, Han, Song, Dong, Yiyu, Hsieh, James J, Leslie, Christina S, Cheng, Emily H

“…SETD2 is a histone H3 lysine 36 (H3K36) trimethyltransferase that is mutated with high prevalence (13%) in clear cell renal cell carcinoma (ccRCC). Genomic…”
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