Search Results - "Dong, Weifan"

Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons by Wang, Jiejie, Lv, Xinyou, Wu, Yu, Xu, Tao, Jiao, Mingfei, Yang, Risheng, Li, Xia, Chen, Ming, Yan, Yinggang, Chen, Changwan, Dong, Weifan, Yang, Wei, Zhuo, Min, Chen, Tao, Luo, Jianhong, Qiu, Shuang

“…NMDA receptors (NMDARs) are crucial for excitatory synaptic transmission and synaptic plasticity. The number and subunit composition of synaptic NMDARs are…”
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A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression by Chen, Xin, Wanggou, Siyi, Bodalia, Ankur, Zhu, Min, Dong, Weifan, Fan, Jerry J., Yin, Wen Chi, Min, Hyun-Kee, Hu, Malini, Draghici, Diana, Dou, Wenkun, Li, Feng, Coutinho, Fiona J., Whetstone, Heather, Kushida, Michelle M., Dirks, Peter B., Song, Yuanquan, Hui, Chi-chung, Sun, Yu, Wang, Lu-Yang, Li, Xuejun, Huang, Xi

“…Alteration of tissue mechanical properties is a physical hallmark of solid tumors including gliomas. How tumor cells sense and regulate tissue mechanics is…”
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CNSC-28. IDENTIFICATION OF EAG2-KVß2 POTASSIUM CHANNEL COMPLEX IN NEURON-GBM COMMUNICATIONS REVEALS GBM VULNERABILITY TO DESIGNER INTERFERENCE PEPTIDE by Dong, Weifan, Chen, Xin, Huang, Xi, Fekete, Adam, Wang, Lu-yang, Liu, Hongwei

“…Abstract Glioblastomas (GBMs) are the most aggressive brain tumors. GBM cells form extensive tumoral networks to communicate with each other and with…”
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Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma by Suzuki, Hiromichi, Kumar, Sachin A., Shuai, Shimin, Diaz-Navarro, Ander, Gutierrez-Fernandez, Ana, De Antonellis, Pasqualino, Cavalli, Florence M. G., Juraschka, Kyle, Farooq, Hamza, Shibahara, Ichiyo, Vladoiu, Maria C., Zhang, Jiao, Abeysundara, Namal, Przelicki, David, Skowron, Patryk, Gauer, Nicole, Luu, Betty, Daniels, Craig, Wu, Xiaochong, Forget, Antoine, Momin, Ali, Wang, Jun, Dong, Weifan, Kim, Seung-Ki, Grajkowska, Wieslawa A., Jouvet, Anne, Fèvre-Montange, Michelle, Garrè, Maria Luisa, Nageswara Rao, Amulya A., Giannini, Caterina, Kros, Johan M, French, Pim J., Jabado, Nada, Ng, Ho-Keung, Poon, Wai Sang, Eberhart, Charles G., Pollack, Ian F., Olson, James M., Weiss, William A., Kumabe, Toshihiro, López-Aguilar, Enrique, Lach, Boleslaw, Massimino, Maura, Van Meir, Erwin G., Rubin, Joshua B., Vibhakar, Rajeev, Chambless, Lola B., Kijima, Noriyuki, Klekner, Almos, Bognár, László, Chan, Jennifer A., Faria, Claudia, Ragoussis, Jiannis, Pfister, Stefan M., Goldenberg, Anna, Wechsler-Reya, Robert J., Bailey, Swneke D., Garzia, Livia, Morrissy, A Sorana, Marra, Marco A., Huang, Xi, Malkin, David, Ayrault, Olivier, Ramaswamy, Vijay, Puente, Xose S., Calarco, John A., Stein, Lincoln, Taylor, Michael D.

“…© The Author(s), under exclusive licence to Springer Nature Limited 2019 In cancer, recurrent somatic single-nucleotide variants-which are rare in most…”
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STEM-27. MECHANOSENSITIVE BRAIN TUMOR CELLS CONSTRUCT BLOOD-TUMOR BARRIER TO MASK CHEMOSENSITIVITY by Chen, Xin, Momin, Ali, Wanggou, Siyi, Wang, Xian, Dong, Weifan, Fan, Jerry, Sun, Yu, Li, Xuejun, Huang, Xi

“…Abstract Two major obstacles in brain cancer treatment are the blood-tumor barrier (BTB) and quiescent tumor cells. Here we show that Sox2+ tumor cells…”
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Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity by Chen, Xin, Momin, Ali, Wanggou, Siyi, Wang, Xian, Min, Hyun-Kee, Dou, Wenkun, Gong, Zheyuan, Chan, Jade, Dong, Weifan, Fan, Jerry J., Xiong, Yi, Talipova, Kamilia, Zhao, Hongyu, Chen, Yuki X., Veerasammy, Kelly, Fekete, Adam, Kumar, Sachin A., Liu, Hongwei, Yang, Qi, Son, Joe Eun, Dou, Zhengchao, Hu, Malini, Pardis, Parnian, Juraschka, Kyle, Donovan, Laura K., Zhang, Jiao, Ramaswamy, Vijay, Selvadurai, Hayden J., Dirks, Peter B., Taylor, Michael D., Wang, Lu-Yang, Hui, Chi-chung, Abzalimov, Rinat, He, Ye, Sun, Yu, Li, Xuejun, Huang, Xi

“…Major obstacles in brain cancer treatment include the blood-tumor barrier (BTB), which limits the access of most therapeutic agents, and quiescent tumor cells,…”
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Pan-cancer ion transport signature reveals functional regulators of glioblastoma aggression by Bahcheli, Alexander T, Min, Hyun-Kee, Bayati, Masroor, Zhao, Hongyu, Fortuna, Alexander, Dong, Weifan, Dzneladze, Irakli, Chan, Jade, Chen, Xin, Guevara-Hoyer, Kissy, Dirks, Peter B, Huang, Xi, Reimand, Jüri

“…Ion channels, transporters, and other ion-flux controlling proteins, collectively comprising the “ion permeome”, are common drug targets, however, their roles…”
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Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth by Francisco, Michelle A, Wanggou, Siyi, Fan, Jerry J, Dong, Weifan, Chen, Xin, Momin, Ali, Abeysundara, Namal, Min, Hyun-Kee, Chan, Jade, McAdam, Rochelle, Sia, Marian, Pusong, Ronwell J, Liu, Shixuan, Patel, Nish, Ramaswamy, Vijay, Kijima, Noriyuki, Wang, Lu-Yang, Song, Yuanquan, Kafri, Ran, Taylor, Michael D, Li, Xuejun, Huang, Xi

“…Ion channels represent a large class of drug targets, but their role in brain cancer is underexplored. Here, we identify that chloride intracellular channel 1…”
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CNSC-20. MONOSYNAPTIC TRACING DEFINES BRAIN-WIDE CIRCUIT CONNECTIVITY OF HUMAN GLIOBLASTOMA by Sun, Yusha, Wang, Xin, Zhang, Daniel, Zhang, Zhijian, Bhattarai, Janardhan, Wang, Yingqi, Park, Kristen, Dong, Weifan, Yang, Qian, Zhang, Feng, Rajamani, Keerthi, Mu, Shang, Kennedy, Benjamin, Hong, Yan, Galanaugh, Jamie, Sambangi, Abhijeet, Kim, Sang Hoon, Wheeler, Garrett, Goncalves, Tiago, Wang, Qing, Geschwind, Daniel, Kawaguchi, Riki, Viaene, Angela, Helbig, Ingo, Kessler, Sudha, Hoke, Ahmet, Wang, Huadong, Xu, Fuqiang, Binder, Zev, Chen, Isaac, Pai, Emily Ling-Lin, Stone, Sara, Nasrallah, MacLean, Christian, Kimberly, Fuccillo, Marc, Toni, Nicolas, Wu, Zhuhao, O’Rourke, Donald, Ma, Minghong, Ming, Guo-li, Song, Hongjun

“…Abstract Glioblastoma (GBM), a deadly brain cancer, infiltrates the brain and can be synaptically innervated by neurons. Synaptic inputs onto GBM cells…”
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Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes by Wang, Xian, Gong, Zheyuan, Wang, Tiancong, Law, Junhui, Chen, Xin, Wanggou, Siyi, Wang, Jintian, Ying, Binbin, Francisco, Michelle, Dong, Weifan, Xiong, Yi, Fan, Jerry J, MacLeod, Graham, Angers, Stephane, Li, Xuejun, Dirks, Peter B, Liu, Xinyu, Huang, Xi, Sun, Yu

“…Glioblastoma (GBM) is the most common and aggressive primary brain cancer. Despite multimodal treatment including surgery, radiotherapy, and chemotherapy,…”
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STEM-26. BLOOD-TUMOR BARRIER IS COMPOSED OF MECHANOSENSING TUMOR CELLS THAT MASK THERAPEUTIC VULNERABILITY by Momin, Ali, Chen, Xin, Wang, Gousiyi, Wang, Xian, Min, Hyun-Kee, Dou, Wenkun, Gong, Zheyuan, Chan, Jade, Chen, Yuki, Veerasammy, Kelly, Dong, Weifan, Fan, Jerry, Fekete, Adam, Dou, Zhengchao, Hu, Malini, Pardis, Parnian, Kumar, Sachin, Juraschka, Kyle, Donovan, Laura, Dirks, Peter, Taylor, Michael D, Wang, Lu-Yang, Hui, Chi-chung, Abzalimov, Rinat, He, Ye, Sun, Yu, Li, Xuejun, Huang, Xi

“…Abstract Two major obstacles in brain cancer treatment are the blood-tumor barrier (BTB), which restricts delivery of most therapeutic agents, and the…”
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A designer peptide against the EAG2–Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma by Dong, Weifan, Fekete, Adam, Chen, Xiaodi, Liu, Hongwei, Beilhartz, Greg L., Chen, Xin, Bahrampour, Shahrzad, Xiong, Yi, Yang, Qi, Zhao, Hongyu, Kong, Tian, Morioka, Malia S., Jung, Geena, Kim, Ji-Eun, Schramek, Daniel, Dirks, Peter B., Song, Yuanquan, Kim, Tae-Hee, He, Ye, Wanggou, Siyi, Li, Xuejun, Melnyk, Roman A., Wang, Lu-Yang, Huang, Xi

“…Glioblastoma (GBM) is an incurable brain cancer that lacks effective therapies. Here we show that EAG2 and Kvβ2, which are predominantly expressed by GBM cells…”
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Recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma by Suzuki, Hiromichi, Kumar, Sachin A, Shuai, Shimin, Diaz-Navarro, Ander, Gutierrez-Fernandez, Ana, De Antonellis, Pasqualino, Cavalli, Florence M G, Juraschka, Kyle, Farooq, Hamza, Shibahara, Ichiyo, Vladoiu, Maria C, Zhang, Jiao, Abeysundara, Namal, Przelicki, David, Skowron, Patryk, Gauer, Nicole, Luu, Betty, Daniels, Craig, Wu, Xiaochong, Forget, Antoine, Momin, Ali, Wang, Jun, Dong, Weifan, Kim, Seung-Ki, Grajkowska, Wieslawa A, Jouvet, Anne, Fèvre-Montange, Michelle, Garrè, Maria Luisa, Rao, Amulya A Nageswara, Giannini, Caterina, Kros, Johan M, French, Pim J, Jabado, Nada, Ng, Ho-Keung, Poon, Wai Sang, Eberhart, Charles G, Pollack, Ian F, Olson, James M, Weiss, William A, Kumabe, Toshihiro, López-Aguilar, Enrique, Lach, Boleslaw, Massimino, Maura, Van Meir, Erwin G, Rubin, Joshua B, Vibhakar, Rajeev, Chambless, Lola B, Kijima, Noriyuki, Klekner, Almos, Bognár, László, Chan, Jennifer A, Faria, Claudia C, Ragoussis, Jiannis, Pfister, Stefan M, Goldenberg, Anna, Wechsler-Reya, Robert J, Bailey, Swneke D, Garzia, Livia, Morrissy, A Sorana, Marra, Marco A, Huang, Xi, Malkin, David, Ayrault, Olivier, Ramaswamy, Vijay, Puente, Xose S, Calarco, John A, Stein, Lincoln, Taylor, Michael D

“…Recurrent somatic single nucleotide variants (SNVs) in cancer are largely confined to protein-coding genes, and are rare in most paediatric cancers . Here we…”
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Recurrent non-coding U1-snRNA mutations drive cryptic splicing in Shh medulloblastoma by Suzuki, Hiromichi, Kumar, Sachin A., Shuai, Shimin, Diaz-Navarro, Ander, Gutierrez-Fernandez, Ana, De Antonellis, Pasqualino, Cavalli, Florence M. G., Juraschka, Kyle, Farooq, Hamza, Shibahara, Ichiyo, Vladoiu, Maria C., Zhang, Jiao, Abeysundara, Namal, Przelicki, David, Skowron, Patryk, Gauer, Nicole, Luu, Betty, Daniels, Craig, Wu, Xiaochong, Forget, Antoine, Momin, Ali, Wang, Jun, Dong, Weifan, Kim, Seung-Ki, Grajkowska, Wieslawa A., Jouvet, Anne, Fèvre-Montange, Michelle, Garrè, Maria Luisa, Nageswara Rao, Amulya A., Giannini, Caterina, Kros, Johan M., French, Pim J., Jabado, Nada, Ng, Ho-Keung, Poon, Wai Sang, Eberhart, Charles G., Pollack, Ian F., Olson, James M., Weiss, William A., Kumabe, Toshihiro, López-Aguilar, Enrique, Lach, Boleslaw, Massimino, Maura, Van Meir, Erwin G., Rubin, Joshua B., Vibhakar, Rajeev, Chambless, Lola B., Kijima, Noriyuki, Klekner, Almos, Bognár, László, Chan, Jennifer A., Faria, Claudia C., Ragoussis, Jiannis, Pfister, Stefan M., Goldenberg, Anna, Wechsler-Reya, Robert J., Bailey, Swneke D., Garzia, Livia, Morrissy, A. Sorana, Marra, Marco A., Huang, Xi, Malkin, David, Ayrault, Olivier, Ramaswamy, Vijay, Puente, Xose S., Calarco, John A., Stein, Lincoln, Taylor, Michael D.

“…Recurrent somatic single nucleotide variants (SNVs) in cancer are largely confined to protein coding genes, and are rare in most pediatric cancers 1 – 3 . We…”
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