Search Results - "Dong, P Duc Si"

Intrahepatic cholangiocyte regeneration from an Fgf‐dependent extrahepatic progenitor niche in a zebrafish model of Alagille Syndrome by Zhao, Chengjian, Lancman, Joseph J., Yang, Yi, Gates, Keith P., Cao, Dan, Barske, Lindsey, Matalonga, Jonathan, Pan, Xiangyu, He, Jiaye, Graves, Alyssa, Huisken, Jan, Chen, Chong, Dong, P. Duc Si

“…Background and Aims Alagille Syndrome (ALGS) is a congenital disorder caused by mutations in the Notch ligand gene JAGGED1, leading to neonatal loss of…”
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Lineage analysis reveals an endodermal contribution to the vertebrate pituitary by Fabian, Peter, Tseng, Kuo-Chang, Smeeton, Joanna, Lancman, Joseph J, Dong, P Duc Si, Cerny, Robert, Crump, J Gage

“…Vertebrate sensory organs arise from epithelial thickenings called placodes. Along with neural crest cells, cranial placodes are considered ectodermal…”
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Endoderm Jagged induces liver and pancreas duct lineage in zebrafish by Zhang, Danhua, Gates, Keith P., Barske, Lindsey, Wang, Guangliang, Lancman, Joseph J., Zeng, Xin-Xin I., Groff, Megan, Wang, Kasper, Parsons, Michael J., Crump, J. Gage, Dong, P. Duc Si

“…Liver duct paucity is characteristic of children born with Alagille Syndrome (ALGS), a disease associated with JAGGED1 mutations. Here, we report that…”
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Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development by Geusz, Ryan J, Wang, Allen, Chiou, Joshua, Lancman, Joseph J, Wetton, Nichole, Kefalopoulou, Samy, Wang, Jinzhao, Qiu, Yunjiang, Yan, Jian, Aylward, Anthony, Ren, Bing, Dong, P Duc Si, Gaulton, Kyle J, Sander, Maike

“…Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as pancreatic islets. Here, we…”
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Fgf10 regulates hepatopancreatic ductal system patterning and differentiation by Stainier, Didier Y R, Dong, P Duc Si, Munson, Chantilly A, Norton, William, Crosnier, Cecile, Pan, Xiufang, Gong, Zhiyuan, Neumann, Carl J

“…During organogenesis, the foregut endoderm gives rise to the many different cell types that comprise the hepatopancreatic system, including hepatic, pancreatic…”
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An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment by Lin, Nianwei, Chang, Kung-Yen, Li, Zhonghan, Gates, Keith, Rana, Zacharia A., Dang, Jason, Zhang, Danhua, Han, Tianxu, Yang, Chao-Shun, Cunningham, Thomas J., Head, Steven R., Duester, Gregg, Dong, P. Duc Si, Rana, Tariq M.

“…Here, we generated a genome-scale shRNA library targeting long intergenic noncoding RNAs (lincRNAs) in the mouse. We performed an unbiased loss-of-function…”
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Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb by Lancman, Joseph J, Zvenigorodsky, Natasha, Gates, Keith P, Zhang, Danhua, Solomon, Keely, Humphrey, Rohan K, Kuo, Taiyi, Setiawan, Linda, Verkade, Heather, Chi, Young-In, Jhala, Ulupi S, Wright, Christopher V E, Stainier, Didier Y R, Dong, P Duc Si

“…Although the liver and ventral pancreas are thought to arise from a common multipotent progenitor pool, it is unclear whether these progenitors of the…”
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A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development by Helker, Christian S M, Mullapudi, Sri-Teja, Mueller, Laura M, Preussner, Jens, Tunaru, Sorin, Skog, Oskar, Kwon, Hyouk-Bum, Kreuder, Florian, Lancman, Joseph J, Bonnavion, Remy, Dong, P Duc Si, Looso, Mario, Offermanns, Stefan, Korsgren, Ole, Spagnoli, Francesca M, Stainier, Didier Y R

“…An early step in pancreas development is marked by the expression of the transcription factor Pdx1 within the pancreatic endoderm, where it is required for the…”
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Genomic Knockout of Two Presumed Forelimb Tbx5 Enhancers Reveals They Are Nonessential for Limb Development by Cunningham, Thomas J., Lancman, Joseph J., Berenguer, Marie, Dong, P. Duc Si, Duester, Gregg

“…A standard approach in the identification of transcriptional enhancers is the use of transgenic animals carrying DNA elements joined to reporter genes inserted…”
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Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness by Cheng, Jiongjia, Tsuda, Masanao, Okolotowicz, Karl, Dwyer, Mary, Bushway, Paul J, Colas, Alexandre R, Lancman, Joseph J, Schade, Dennis, Perea-Gil, Isaac, Bruyneel, Arne A N, Lee, Jaechol, Vadgama, Nirmal, Quach, Justine, McKeithan, Wesley L, Biechele, Travis L, Wu, Joseph C, Moon, Randall T, Si Dong, P Duc, Karakikes, Ioannis, Cashman, John R, Mercola, Mark

“…Wnt signaling plays a central role in tissue maintenance and cancer. Wnt activates downstream genes through β-catenin, which interacts with TCF/LEF…”
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Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration by Anderson, Ryan M., Bosch, Justin A., Goll, Mary G., Hesselson, Daniel, Dong, P. Duc Si, Shin, Donghun, Chi, Neil C., Shin, Chong Hyun, Schlegel, Amnon, Halpern, Marnie, Stainier, Didier Y.R.

“…Developmental mechanisms regulating gene expression and the stable acquisition of cell fate direct cytodifferentiation during organogenesis. Moreover, it is…”
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Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas by Dong, P Duc Si, Provost, Elayne, Leach, Steven D, Stainier, Didier Y R

“…The mechanisms regulating pancreatic endocrine versus exocrine fate are not well defined. By analyzing the effects of Ptf1a partial loss of function, we…”
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Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling by Zhao, Chengjian, Matalonga, Jonathan, Lancman, Joseph J, Liu, Lu, Xiao, Chaoxin, Kumar, Shiv, Gates, Keith P, He, Jiaye, Graves, Alyssa, Huisken, Jan, Azuma, Mizuki, Lu, Zhenghao, Chen, Chong, Ding, Bi-Sen, Dong, P Duc Si

“…Despite the robust healing capacity of the liver, regenerative failure underlies numerous hepatic diseases, including the haploinsufficient disorder, Alagille…”
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Mouse but not zebrafish requires retinoic acid for control of neuromesodermal progenitors and body axis extension by Berenguer, Marie, Lancman, Joseph J., Cunningham, Thomas J., Dong, P. Duc Si, Duester, Gregg

“…In mouse, retinoic acid (RA) is required for the early phase of body axis extension controlled by a population of neuromesodermal progenitors (NMPs) in the…”
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Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival by Zhang, Danhua, Golubkov, Vladislav S, Han, Wenlong, Correa, Ricardo G, Zhou, Ying, Lee, Sunyoung, Strongin, Alex Y, Dong, P Duc Si

“…To gain insight into liver and pancreas development, we investigated the target of 2F11, a monoclonal antibody of unknown antigen, widely used in zebrafish…”
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Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis by Ng, Annie N.Y., de Jong-Curtain, Tanya A., Mawdsley, David J., White, Sara J., Shin, Jimann, Appel, Bruce, Dong, P. Duc Si, Stainier, Didier Y.R., Heath, Joan K.

“…Recent analysis of a novel strain of transgenic zebrafish (gutGFP) has provided a detailed description of the early morphological events that occur during the…”
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Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia by Liu, Chao, Gates, Keith P, Fang, Longhou, Amar, Marcelo J, Schneider, Dina A, Geng, Honglian, Huang, Wei, Kim, Jungsu, Pattison, Jennifer, Zhang, Jian, Witztum, Joseph L, Remaley, Alan T, Dong, P Duc, Miller, Yury I

“…Apolipoprotein C-II (APOC2) is an obligatory activator of lipoprotein lipase. Human patients with APOC2 deficiency display severe hypertriglyceridemia while…”
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Organ-specific requirements for Hdac1 in liver and pancreas formation by Noël, Emily S., Casal-Sueiro, Antonio, Busch-Nentwich, Elisabeth, Verkade, Heather, Dong, P. Duc Si, Stemple, Derek L., Ober, Elke A.

“…Liver, pancreas and lung originate from the presumptive foregut in temporal and spatial proximity. This requires precisely orchestrated transcriptional…”
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An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment by Lin, Nianwei, Chang, Kung-Yen, Li, Zhonghan, Gates, Keith, Rana, Zacharia A., Dang, Jason, Zhang, Danhua, Han, Tianxu, Yang, Chao-Shun, Cunningham, Thomas J., Head, Steven R., Duester, Gregg, Dong, P. Duc Si, Rana, Tariq M.

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