Search Results - "Doney, Alexander S."

Competing risks analysis for neutrophil to lymphocyte ratio as a predictor of diabetic retinopathy incidence in the Scottish population by Rajendrakumar, Aravind Lathika, Hapca, Simona M, Nair, Anand Thakarakkattil Narayanan, Huang, Yu, Chourasia, Mehul Kumar, Kwan, Ryan Shun-Yuen, Nangia, Charvi, Siddiqui, Moneeza K, Vijayaraghavan, Prathiba, Matthew, Shona Z, Leese, Graham P, Mohan, Viswanathan, Pearson, Ewan R, Doney, Alexander S F, Palmer, Colin N A

“…Diabetic retinopathy (DR) is a major sight-threatening microvascular complication in individuals with diabetes. Systemic inflammation combined with oxidative…”
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Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations by Srinivasan, Sundararajan, Liju, Samuel, Sathish, Natarajan, Siddiqui, Moneeza K, Anjana, Ranjit Mohan, Pearson, Ewan R, Doney, Alexander S F, Mohan, Viswanathan, Radha, Venkatesan, Palmer, Colin N A

“…South Asians are diagnosed with type 2 diabetes (T2D) more than a decade earlier in life than seen in European populations. We hypothesized that studying the…”
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Prescribing Antiplatelet Medicine and Subsequent Events After Intracerebral Hemorrhage by FLYNN, Robert W. V, MACDONALD, Thomas M, MURRAY, Gordon D, MACWALTER, Ronald S, DONEY, Alexander S. F

“…Antiplatelet medicines are commonly perceived as contraindicated after intracerebral hemorrhage (ICH). Many ICH patients have or will have indications for…”
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Neutrophil‐to‐lymphocyte ratio and outcomes in patients with new‐onset or worsening heart failure with reduced and preserved ejection fraction by Curran, Fraser M., Bhalraam, U, Mohan, Mohapradeep, Singh, Jagdeep S., Anker, Stefan D., Dickstein, Kenneth, Doney, Alexander S., Filippatos, Gerasimos, George, Jacob, Metra, Marco, Ng, Leong L., Palmer, Colin N., Samani, Nilesh J., Veldhuisen, Dirk J., Voors, Adriaan A., Lang, Chim C., Mordi, Ify R.

“…Aims Inflammation is thought to play a role in heart failure (HF) pathophysiology. Neutrophil‐to‐lymphocyte ratio (NLR) is a simple, routinely available…”
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Insulin Resistance Is Highly Prevalent and Is Associated With Reduced Exercise Tolerance in Nondiabetic Patients With Heart Failure by ALZadjali, Matlooba A., MD, MPH, Godfrey, Valerie, PhD, Khan, Faisel, PhD, Choy, AnnaMaria, FRCP, FACC, Doney, Alexander S., MD, Wong, Aaron K., MBChB, MRCP, Petrie, John R., MD, FRCP, Struthers, Allan D., MD, FRCP, Lang, Chim C., MD, FACC

“…Objectives The purpose of this study was to establish the prevalence of insulin resistance (IR) among nondiabetic chronic heart failure (CHF) patients and to…”
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Evaluating Diuretics in Normal Care (EVIDENCE): a feasibility report of a pilot cluster randomised trial of prescribing policy in primary care to compare the effectiveness of thiazide-type diuretics in hypertension by Flynn, Angela, Rogers, Amy, McConnachie, Lewis, Barr, Rebecca, Flynn, Robert W V, Mackenzie, Isla S, MacDonald, Thomas M, Doney, Alexander S F

“…Obtaining evidence on comparative effectiveness and safety of widely prescribed drugs in a timely and cost-effective way is a major challenge for healthcare…”
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The cholesterol-lowering effect of statins is modified by LILRB5 intolerance genotype: Results from a recruit-by-genotype clinical trial by Tornio, Aleksi, Bigossi, Margherita, Siddiqui, Moneeza K, Kennedy, Gwen, Melhem, Ala'a, Chourasia, Mehul K, Maroteau, Cyrielle, Pola, Roberto, Chasman, Daniel I, Doney, Alexander S F, Palmer, Colin N A

“…Statin intolerance leads to poor adherence to statin therapy, resulting in a failure to achieve desired cholesterol reduction and adverse outcomes. The…”
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Precision Medicine and Adverse Drug Reactions Related to Cardiovascular Drugs by Noyes, James D., Mordi, Ify R., Doney, Alexander S., Jamal, Rahman, Lang, Chim C.

“…Cardiovascular disease remains the leading global cause of death. Early intervention, with lifestyle advice alongside appropriate medical therapies, is…”
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Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors by Mahmoudpour, Seyed H, Veluchamy, Abirami, Siddiqui, Moneeza K, Asselbergs, Folkert W, Souverein, Patrick C, de Keyser, Catherine E, Hofman, Albert, Lang, Chim C, Doney, Alexander S.F, Stricker, Bruno H, de Boer, Anthonius, Maitland-van der Zee, Anke H, Palmer, Colin N.A

“…OBJECTIVESTo identify single nucleotide polymorphisms (SNPs) associated with switching from an angiotensin-converting enzyme (ACE)-inhibitor to an angiotensin…”
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Impact of EMA regulatory label changes on hydroxyzine initiation, discontinuation and switching to other medicines in Denmark, Scotland, England and the Netherlands: An interrupted time series regression analysis by Morales, Daniel R., Macfarlane, Tatiana, MacDonald, Thomas M., Hallas, Jesper, Ernst, Martin Thomsen, Herings, Ron M. C., Smits, Elisabeth, Overbeek, Jetty A., Mitchell, Lyn, Morant, Steven, Mackenzie, Isla, Doney, Alexander S. F., Robertson, Chris, Bennie, Marion, Wei, Li, Nicholson, Lizzie, Morris, Carole, Flynn, Robert W. F.

“…Background Hydroxyzine is indicated for the management of anxiety, skin and sleep disorders. In 2015, the European Medicines Agency (EMA) concluded that…”
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Retinal vascular measures from diabetes retinal screening photographs and risk of incident dementia in type 2 diabetes: A GoDARTS study by Doney, Alexander S. F., Nar, Aditya, Huang, Yu, Trucco, Emanuele, MacGillivray, Tom, Connelly, Peter, Leese, Graham P., McKay, Gareth J.

“…Objective Patients with diabetes have an increased risk of dementia. Improved prediction of dementia is an important goal in developing future prevention…”
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A review of machine learning methods for retinal blood vessel segmentation and artery/vein classification by Mookiah, Muthu Rama Krishnan, Hogg, Stephen, MacGillivray, Tom J, Prathiba, Vijayaraghavan, Pradeepa, Rajendra, Mohan, Viswanathan, Anjana, Ranjit Mohan, Doney, Alexander S., Palmer, Colin N.A., Trucco, Emanuele

“…•Recent vessel segmentation using machine and deep learning methods are reviewed.•Performance of non-deep learning and deep learning methods are evaluated.•An…”
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The PREPARE study: benefits of pharmacogenetic testing are unclear by Curtis, David

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Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) by Hébert, Harry L, Shepherd, Bridget, Milburn, Keith, Veluchamy, Abirami, Meng, Weihua, Carr, Fiona, Donnelly, Louise A, Tavendale, Roger, Leese, Graham, Colhoun, Helen M, Dow, Ellie, Morris, Andrew D, Doney, Alexander S, Lang, Chim C, Pearson, Ewan R, Smith, Blair H, Palmer, Colin N A

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Persistence, adherence and outcomes with antiplatelet regimens following cerebral infarction in the Tayside Stroke Cohort by Flynn, Robert W V, MacDonald, Thomas M, Murray, Gordon D, MacWalter, Ronald S, Doney, Alexander S F

“…Co-prescribed aspirin and dipyridamole are more effective than aspirin alone following cerebral infarction; however, patients may struggle with this more…”
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Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study by Siddiqui, Moneeza K., Kennedy, Gwen, Carr, Fiona, Doney, Alexander S. F., Pearson, Ewan R., Morris, Andrew D., Johnson, Toby, McLaughlin, Megan M., Williams, Rachel E., Palmer, Colin N. A.

“…Aims/hypothesis The aim of the study was to examine the association between lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) activity levels and incident…”
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Genetic Risk of Diverticular Disease Predicts Early Stoppage of Nicorandil by Noyes, James D., Mordi, Ify R., Doney, Alexander S., Palmer, Colin N. A., Pearson, Ewan R., Lang, Chim C.

“…Gastrointestinal fistulation has been widely reported as an adverse effect of nicorandil therapy in Europe. People who have underlying diverticular disease are…”
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Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease by Veluchamy, Abirami, Ballerini, Lucia, Vitart, Veronique, Schraut, Katharina E, Kirin, Mirna, Campbell, Harry, Joshi, Peter K, Relan, Devanjali, Harris, Sarah, Brown, Ellie, Vaidya, Suraj S, Dhillon, Baljean, Zhou, Kaixin, Pearson, Ewan R, Hayward, Caroline, Polasek, Ozren, Deary, Ian J, MacGillivray, Thomas, Wilson, James F, Trucco, Emanuele, Palmer, Colin N.A, Doney, Alexander S.F

“…OBJECTIVE:The retina may provide readily accessible imaging biomarkers of global cardiovascular health. Increasing evidence suggests variation in retinal…”
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A multimodal approach to cardiovascular risk stratification in patients with type 2 diabetes incorporating retinal, genomic and clinical features by Fetit, Ahmed E., Doney, Alexander S., Hogg, Stephen, Wang, Ruixuan, MacGillivray, Tom, Wardlaw, Joanna M., Doubal, Fergus N., McKay, Gareth J., McKenna, Stephen, Trucco, Emanuele

“…Cardiovascular diseases are a public health concern; they remain the leading cause of morbidity and mortality in patients with type 2 diabetes. Phenotypic…”
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Modulation of intracellular ATP determines adenosine release and functional outcome in response to metabolic stress in rat hippocampal slices and cerebellar granule cells by Nedden, Stephanie zur, Doney, Alexander S., Frenguelli, Bruno G.

“…Cerebral ischaemia rapidly depletes cellular ATP. Whilst this deprives brain tissue of a valuable energy source, the concomitant production of adenosine…”
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