Search Results - "Donegan, Rebecca K."

Regulation of heme biosynthesis via the coproporphyrin dependent pathway in bacteria by Aftab, Hadia, Donegan, Rebecca K

“…Heme biosynthesis in the Gram-positive bacteria occurs mostly via a pathway that is distinct from that of eukaryotes and Gram-negative bacteria in the three…”
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Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies by Hill, Shannon E, Donegan, Rebecca K, Nguyen, Elaine, Desai, Tanay M, Lieberman, Raquel L

“…Olfactomedin (OLF) domains are found within extracellular, multidomain proteins in numerous tissues of multicellular organisms. Even though these proteins have…”
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Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis by Donegan, Rebecca K, Fu, Yibo, Copeland, Jacqueline, Idga, Stanzin, Brown, Gabriel, Hale, Owen F, Mitra, Avishek, Yang, Hui, Dailey, Harry A, Niederweis, Michael, Jain, Paras, Reddi, Amit R

“…Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M…”
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Handling heme: The mechanisms underlying the movement of heme within and between cells by Donegan, Rebecca K., Moore, Courtney M., Hanna, David A., Reddi, Amit R.

“…Heme is an essential cofactor and signaling molecule required for virtually all aerobic life. However, excess heme is cytotoxic. Therefore, heme must be safely…”
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Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions by Donegan, Rebecca K, Lieberman, Raquel L

“…Glaucoma, a heterogeneous ocular disorder affecting ∼60 million people worldwide, is characterized by painless neurodegeneration of retinal ganglion cells…”
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Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans by Weissman, Ziva, Pinsky, Mariel, Donegan, Rebecca K., Reddi, Amit R., Kornitzer, Daniel

“…Candida albicans is a major fungal pathogen that can utilise hemin and haemoglobin as iron sources in the iron‐scarce host environment. While C. albicans is a…”
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Structural basis for misfolding in myocilin-associated glaucoma by Donegan, Rebecca K, Hill, Shannon E, Freeman, Dana M, Nguyen, Elaine, Orwig, Susan D, Turnage, Katherine C, Lieberman, Raquel L

“…Olfactomedin (OLF) domain-containing proteins play roles in fundamental cellular processes and have been implicated in disorders ranging from glaucoma, cancers…”
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Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin by Hill, Shannon E., Nguyen, Elaine, Donegan, Rebecca K., Patterson-Orazem, Athéna C., Hazel, Anthony, Gumbart, James C., Lieberman, Raquel L.

“…Glaucoma-associated myocilin is a member of the olfactomedins, a protein family involved in neuronal development and human diseases. Molecular studies of the…”
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The Glaucoma-Associated Olfactomedin Domain of Myocilin Forms Polymorphic Fibrils That Are Constrained by Partial Unfolding and Peptide Sequence by Hill, Shannon E., Donegan, Rebecca K., Lieberman, Raquel L.

“…The glaucoma-associated olfactomedin domain of myocilin (myoc-OLF) is a recent addition to the growing list of disease-associated amyloidogenic proteins…”
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A blueprint for academic laboratories to produce SARS-CoV-2 quantitative RT-PCR test kits by Mascuch, Samantha J., Fakhretaha-Aval, Sara, Bowman, Jessica C., Ma, Minh Thu H., Thomas, Gwendell, Bommarius, Bettina, Ito, Chieri, Zhao, Liangjun, Newnam, Gary P., Matange, Kavita R., Thapa, Hem R., Barlow, Brett, Donegan, Rebecca K., Nguyen, Nguyet A., Saccuzzo, Emily G., Obianyor, Chiamaka T., Karunakaran, Suneesh C., Pollet, Pamela, Rothschild-Mancinelli, Brooke, Mestre-Fos, Santi, Guth-Metzler, Rebecca, Bryksin, Anton V., Petrov, Anton S., Hazell, Mallory, Ibberson, Carolyn B., Penev, Petar I., Mannino, Robert G., Lam, Wilbur A., Garcia, Andrés J., Kubanek, Julia, Agarwal, Vinayak, Hud, Nicholas V., Glass, Jennifer B., Williams, Loren Dean, Lieberman, Raquel L.

“…Widespread testing for the presence of the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals remains vital for…”
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Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions: Miniperspective by Donegan, Rebecca K, Lieberman, Raquel L

“…Glaucoma, a heterogeneous ocular disorder affecting ∼60 million people worldwide, is characterized by painless neurodegeneration of retinal ganglion cells…”
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Heme and hemoglobin suppress amyloid β–mediated inflammatory activation of mouse astrocytes by Sankar, Sitara B., Donegan, Rebecca K., Shah, Kajol J., Reddi, Amit R., Wood, Levi B.

“…Glial immune activity is a key feature of Alzheimer's disease (AD). Given that the blood factors heme and hemoglobin (Hb) are both elevated in AD tissues and…”
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The Glaucoma-associated Olfactomedin Domain of Myocilin Is a Novel Calcium Binding Protein by Donegan, Rebecca K., Hill, Shannon E., Turnage, Katherine C., Orwig, Susan D., Lieberman, Raquel L.

“…Myocilin is a protein found in the trabecular meshwork extracellular matrix tissue of the eye that plays a role in regulating intraocular pressure. Both…”
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Fluorometric Methods to Measure Bioavailable and Total Heme by Dominic, Iramofu M, Willoughby, Mathilda M, Freer, Abigail K, Moore, Courtney M, Donegan, Rebecca K, Martinez-Guzman, Osiris, Hanna, David A, Reddi, Amit R

“…Heme b (iron protoporphyrin IX) is an essential but potentially cytotoxic cofactor, signaling molecule, and nutritional source of iron. Its importance in cell…”
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New direction for glaucoma therapeutics: focus on the olfactomedin domain of myocilin by Donegan, Rebecca K, Lieberman, Raquel L

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HEME AND HEMOGLOBIN SUPPRESS AMYLOID BETA-MEDIATED ASTROCYTE IMMUNE FUNCTION by Sankar, Sitara B., Donegan, Rebecca K., Shah, Kajol J., Reddi, Amit R., Wood, Levi

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P2‐196: HEME AND HEMOGLOBIN SUPPRESS AMYLOID BETA‐MEDIATED ASTROCYTE IMMUNE FUNCTION by Sankar, Sitara B., Donegan, Rebecca K., Shah, Kajol J., Reddi, Amit R., Wood, Levi

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Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin by Hill, Shannon E., Nguyen, Elaine, Donegan, Rebecca K., Patterson-Orazem, Athéna C., Hazel, Anthony, Gumbart, James C., Lieberman, Raquel L.

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Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies: e0130888 by Hill, Shannon E, Donegan, Rebecca K, Nguyen, Elaine, Desai, Tanay M, Lieberman, Raquel L

“…Olfactomedin (OLF) domains are found within extracellular, multidomain proteins in numerous tissues of multicellular organisms. Even though these proteins have…”
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