Search Results - "Donde, Aneesh"

Splicing repression is a major function of TDP-43 in motor neurons by Donde, Aneesh, Sun, Mingkuan, Ling, Jonathan P., Braunstein, Kerstin E., Pang, Bo, Wen, Xinrui, Cheng, Xueying, Chen, Liam, Wong, Philip C.

“…Nuclear depletion of TDP-43, an essential RNA binding protein, may underlie neurodegeneration in amyotrophic lateral sclerosis (ALS). As several functions have…”
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Tdp-43 cryptic exons are highly variable between cell types by Jeong, Yun Ha, Ling, Jonathan P, Lin, Sophie Z, Donde, Aneesh N, Braunstein, Kerstin E, Majounie, Elisa, Traynor, Bryan J, LaClair, Katherine D, Lloyd, Thomas E, Wong, Philip C

“…TDP-43 proteinopathy is a prominent pathological feature that occurs in a number of human diseases including amyotrophic lateral sclerosis (ALS),…”
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Challenges and Advances in Gene Therapy Approaches for Neurodegenerative Disorders by Donde, Aneesh, Wong, Philip C, Chen, Liam L

“…The recent approval of Spinraza (nusinersen), an antisense oligonucleotide, by U.S. Food and Drug Administration to treat patients with spinal muscular…”
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Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions by Arjomandi, Mehrdad, Frelinger, Jessica, Donde, Aneesh, Wong, Hofer, Yellamilli, Amritha, Raymond, Wilfred

“…Osteopontin (OPN) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family and a cytokine with diverse biologic roles. OPN…”
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Effects of Exercise on Systemic Inflammatory, Coagulatory, and Cardiac Autonomic Parameters in an Inhalational Exposure Study by Donde, Aneesh, Wong, Hofer, Frelinger, Jessica, Power, Karron, Balmes, John R., Arjomandi, Mehrdad

“…Background: Intermittent moderate-intensity exercise is used in human inhalational exposure studies to increase the effective dose of air pollutants…”
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Exposure to medium and high ambient levels of ozone causes adverse systemic inflammatory and cardiac autonomic effects by Arjomandi, Mehrdad, Wong, Hofer, Donde, Aneesh, Frelinger, Jessica, Dalton, Sarah, Ching, Wendy, Power, Karron, Balmes, John R

“…Epidemiological evidence suggests that exposure to ozone increases cardiovascular morbidity. However, the specific biological mechanisms mediating…”
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Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43 by Donde, Aneesh, Sun, Mingkuan, Jeong, Yun Ha, Wen, Xinrui, Ling, Jonathan, Lin, Sophie, Braunstein, Kerstin, Nie, Shuke, Wang, Sheng, Chen, Liam, Wong, Philip C.

“…A shared neuropathological hallmark in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is nuclear clearance and cytoplasmic aggregation…”
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Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines by Baxi, Emily G., Thompson, Terri, Kaye, Julia A., Lim, Ryan G., Wu, Jie, Ramamoorthy, Divya, Lima, Leandro, Vaibhav, Vineet, Matlock, Andrea, Frank, Aaron, Coyne, Alyssa N., Landin, Barry, Ornelas, Loren, Mosmiller, Elizabeth, Thrower, Sara, Farr, S. Michelle, Panther, Lindsey, Gomez, Emilda, Galvez, Erick, Perez, Daniel, Meepe, Imara, Lei, Susan, Mandefro, Berhan, Trost, Hannah, Pinedo, Louis, Banuelos, Maria G., Liu, Chunyan, Moran, Ruby, Garcia, Veronica, Workman, Michael, Ho, Richie, Wyman, Stacia, Roggenbuck, Jennifer, Harms, Matthew B., Stocksdale, Jennifer, Miramontes, Ricardo, Wang, Keona, Venkatraman, Vidya, Holewenski, Ronald, Sundararaman, Niveda, Pandey, Rakhi, Manalo, Danica-Mae, Donde, Aneesh, Huynh, Nhan, Adam, Miriam, Wassie, Brook T., Vertudes, Edward, Amirani, Naufa, Raja, Krishna, Thomas, Reuben, Hayes, Lindsey, Lenail, Alex, Cerezo, Aianna, Luppino, Sarah, Farrar, Alanna, Pothier, Lindsay, Prina, Carolyn, Morgan, Todd, Jamil, Arish, Heintzman, Sarah, Jockel-Balsarotti, Jennifer, Karanja, Elizabeth, Markway, Jesse, McCallum, Molly, Joslin, Ben, Alibazoglu, Deniz, Kolb, Stephen, Ajroud-Driss, Senda, Baloh, Robert, Heitzman, Daragh, Miller, Tim, Glass, Jonathan D., Patel-Murray, Natasha Leanna, Yu, Hong, Sinani, Ervin, Vigneswaran, Prasha, Sherman, Alexander V., Ahmad, Omar, Roy, Promit, Beavers, Jay C., Zeiler, Steven, Krakauer, John W., Agurto, Carla, Cecchi, Guillermo, Bellard, Mary, Raghav, Yogindra, Sachs, Karen, Ehrenberger, Tobias, Bruce, Elizabeth, Cudkowicz, Merit E., Maragakis, Nicholas, Norel, Raquel, Van Eyk, Jennifer E., Finkbeiner, Steven, Berry, James, Sareen, Dhruv, Thompson, Leslie M., Fraenkel, Ernest, Svendsen, Clive N., Rothstein, Jeffrey D.

“…Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons and…”
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Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer’s mouse model by LaClair, Katherine D., Donde, Aneesh, Ling, Jonathan P., Jeong, Yun Ha, Chhabra, Resham, Martin, Lee J., Wong, Philip C.

“…TDP-43 proteinopathy, initially associated with ALS and FTD, is also found in 30–60% of Alzheimer’s disease (AD) cases and correlates with worsened cognition…”
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Striatal dopamine influences the default mode network to affect shifting between object features by Dang, Linh C, Donde, Aneesh, Madison, Cindee, O'Neil, James P, Jagust, William J

“…Cognitive flexibility or the ability to change behavior in response to external cues is conceptualized as two processes: one for shifting between perceptual…”
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Developmental basis of SHH medulloblastoma heterogeneity by Gold, Maxwell P., Ong, Winnie, Masteller, Andrew M., Ghasemi, David R., Galindo, Julie Anne, Park, Noel R., Huynh, Nhan C., Donde, Aneesh, Pister, Veronika, Saurez, Raul A., Vladoiu, Maria C., Hwang, Grace H., Eisemann, Tanja, Donovan, Laura K., Walker, Adam D., Benetatos, Joseph, Dufour, Christelle, Garzia, Livia, Segal, Rosalind A., Wechsler-Reya, Robert J., Mesirov, Jill P., Korshunov, Andrey, Pajtler, Kristian W., Pomeroy, Scott L., Ayrault, Olivier, Davidson, Shawn M., Cotter, Jennifer A., Taylor, Michael D., Fraenkel, Ernest

“…Many genes that drive normal cellular development also contribute to oncogenesis. Medulloblastoma (MB) tumors likely arise from neuronal progenitors in the…”
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Depletion of TDP-43 decreases fibril and plaque [beta]-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model by LaClair, Katherine D, Donde, Aneesh, Ling, Jonathan P, Jeong, Yun Ha, Chhabra, Resham, Ma, Wong, Philip C

“…TDP-43 proteinopathy, initially associated with ALS and FTD, is also found in 30-60% of Alzheimer's disease (AD) cases and correlates with worsened cognition…”
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Ozone inhalation leads to a dose-dependent increase of cytogenetic damage in human lymphocytes by Holland, Nina, Davé, Veronica, Venkat, Subha, Wong, Hofer, Donde, Aneesh, Balmes, John R., Arjomandi, Mehrdad

“…Ozone is an important constituent of ambient air pollution and represents a major public health concern. Oxidative injury due to ozone inhalation causes the…”
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Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data by Ramamoorthy, Divya, Severson, Kristen, Ghosh, Soumya, Sachs, Karen, Glass, Jonathan D, Fournier, Christina N, Herrington, Todd M, Berry, James D, Ng, Kenney, Fraenkel, Ernest

“…The clinical presentation of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, varies widely across patients, making it challenging to…”
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Splicing Repression Is a Major Function of TDP-43 in Motor Neurons: Therapeutic Implications for Amyotrophic Lateral Sclerosis by Donde, Aneesh N

“…Nuclear depletion of TDP-43, an RNA binding protein which serves to protect the transcriptome by repressing aberrant splicing, may underlie neurodegeneration…”
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Oxidative Injury Due to Inhalation of Ozone Causes Dose-Dependent Cytogenetic Damage in Peripheral Blood Lymphocytes by Arjomandi, Mehrdad, Venkat, Subha, Wong, Hofer, Donde, Aneesh, Balmes, John, Holland, Nina

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