Search Results - "Donato Jr, Jose"

Impact of Growth Hormone on Microglial and Astrocytic Function by Tavares, Mariana R, Wasinski, Frederick, Metzger, Martin, Donato, Jr, Jose

“…The role of growth hormone (GH) in the central nervous system (CNS) involves neuroprotection, neuroregeneration, formation of axonal projections, control of…”
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Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus by Kim, Ki Woo, Zhao, Liping, Donato, Jose Jr, Kohno, Daisuke, Xu, Yong, Elias, Carol F, Lee, Charlotte, Parker, Keith L, Elmquist, Joel K

“…The transcription factor steroidogenic factor 1 (SF-1) is exclusively expressed in the brain in the ventral medial hypothalamic nucleus (VMH) and is required…”
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Effects of growth hormone in the central nervous system by Wasinski, Frederick, Frazão, Renata, Donato, Jr, Jose

“…Growth hormone (GH) is best known for its effect stimulating tissue and somatic growth through the regulation of cell division, regeneration and proliferation…”
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TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation by Moura-Assis, Alexandre, Nogueira, Pedro A. S., de-Lima-Junior, Jose C., Simabuco, Fernando M., Gaspar, Joana M., Donato Jr, Jose, Velloso, Licio A.

“…Obesity and high-fat diet (HFD) consumption result in hypothalamic inflammation and metabolic dysfunction. While the TLR4 activation by dietary fats is a…”
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Effects of Growth Hormone Receptor Ablation in Corticotropin-Releasing Hormone Cells by Dos Santos, Willian O, Gusmao, Daniela O, Wasinski, Frederick, List, Edward O, Kopchick, John J, Donato, Jr, Jose

“…Corticotropin-releasing hormone (CRH) cells are the dominant neuronal population responsive to the growth hormone (GH) in the paraventricular nucleus of the…”
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The central nervous system as a promising target to treat diabetes mellitus by Donato, Jr, Jose

“…Most of the drugs available to treat type 2 diabetes mellitus (T2DM) act either in the pancreas by increasing insulin secretion or in tissues such as the liver…”
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Interactions between prolactin and kisspeptin to control reproduction by Donato, Jr, Jose, Frazão, Renata

“…Prolactin is best known for its effects of stimulating mammary gland development and lactogenesis. However, prolactin is a pleiotropic hormone that is able to…”
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P110β in the ventromedial hypothalamus regulates glucose and energy metabolism by Fujikawa, Teppei, Choi, Yun-Hee, Yang, Dong Joo, Shin, Dong Min, Donato, Jose, Kohno, Daisuke, Lee, Charlotte E., Elias, Carol F., Lee, Syann, Kim, Ki Woo

“…Phosphoinositide 3-kinase (PI3K) signaling in hypothalamic neurons integrates peripheral metabolic cues, including leptin and insulin, to coordinate systemic…”
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Deletion of miRNA-22 Induces Cardiac Hypertrophy in Females but Attenuates Obesogenic Diet-Mediated Metabolic Disorders by de Oliveira Silva, Tábatha, Lino, Caroline A., Buzatto, Vanessa C., Fontes Asprino, Paula, Lu, Yao Wei, Lima, Vanessa M., Fonseca, Renata I. B., Jensen, Leonardo, Murata, Gilson M., Filho, Sidney V., Ribeiro, Márcio A. C., Donato Jr, Jose, Ferreira, Julio C. B., Rodrigues, Alice C., Irigoyen, Maria Cláudia, Barreto-Chaves, Maria Luiza M., Huang, Zhan-Peng, Favoretto Galante, Pedro A., Wang, Da-Zhi, Diniz, Gabriela P.

“…Background/Aims: Obesity is a risk factor associated with cardiometabolic complications. Recently, we reported that miRNA-22 deletion attenuated high-fat…”
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New findings on brain actions of growth hormone and potential clinical implications by Donato, Jose, Kopchick, John J.

“…Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The classical effects of GH comprise the stimulation of cell…”
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Distribution of growth hormone-responsive cells in the brain of rats and mice by Wasinski, Frederick, Klein, Marianne O., Bittencourt, Jackson C., Metzger, Martin, Donato, Jose

“…•pSTAT5 can be used as a marker of GH-responsive cells in the brain of GH-injected rats.•Rats and mice exhibit a fairly similar brain distribution of…”
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Lateral habenula and the rostromedial tegmental nucleus innervate neurochemically distinct subdivisions of the dorsal raphe nucleus in the rat by Sego, Chemutai, Gonçalves, Luciano, Lima, Leandro, Furigo, Isadora C., Donato Jr, Jose, Metzger, Martin

“…ABSTRACT The lateral habenula (LHb) is an epithalamic structure differentiated in a medial (LHbM) and a lateral division (LHbL). Together with the rostromedial…”
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Neurochemical phenotype of growth hormone‐responsive cells in the mouse paraventricular nucleus of the hypothalamus by Quaresma, Paula G. F., Santos, Willian O., Wasinski, Frederick, Metzger, Martin, Donato, Jose

“…Multiple neuroendocrine, autonomic and behavioral responses are regulated by the paraventricular nucleus of the hypothalamus (PVH). Previous studies have shown…”
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Tyrosine Hydroxylase Neurons Regulate Growth Hormone Secretion via Short-Loop Negative Feedback by Wasinski, Frederick, Pedroso, João A B, Dos Santos, Willian O, Furigo, Isadora C, Garcia-Galiano, David, Elias, Carol F, List, Edward O, Kopchick, John J, Szawka, Raphael E, Donato, Jr, Jose

“…Classical studies suggest that growth hormone (GH) secretion is controlled by negative-feedback loops mediated by GH-releasing hormone (GHRH)- or…”
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Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice by Berglund, Eric D, Vianna, Claudia R, Donato, Jr, Jose, Kim, Mi Hwa, Chuang, Jen-Chieh, Lee, Charlotte E, Lauzon, Danielle A, Lin, Peagan, Brule, Laura J, Scott, Michael M, Coppari, Roberto, Elmquist, Joel K

“…Leptin action on its receptor (LEPR) stimulates energy expenditure and reduces food intake, thereby lowering body weight. One leptin-sensitive target cell…”
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Leptin receptor reactivation restores brain function in early-life Lepr-deficient mice by Fernandes, Caroline, Forny-Germano, Leticia, Andrade, Mayara M, Lyra E Silva, Natalia M, Ramos-Lobo, Angela M, Meireles, Fernanda, Tovar-Moll, Fernanda, Houzel, Jean Christophe, Donato, Jr, Jose, De Felice, Fernanda G

“…Obesity is a chronic disease caused by excessive fat accumulation that impacts the body and brain health. Insufficient leptin or leptin receptor (LepR) is…”
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Growth hormone enhances the recovery of hypoglycemia via ventromedial hypothalamic neurons by Furigo, Isadora C., Souza, Gabriel O., Teixeira, Pryscila D. S., Guadagnini, Dioze, Frazão, Renata, List, Edward O., Kopchick, John J., Prada, Patricia O., Jr, Jose Donato

“…Growth hormone (GH) is secreted during hypoglycemia, and GH‐responsive neurons are found in brain areas containing glucose‐sensing neurons that regulate the…”
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Fasting and prolonged food restriction differentially affect GH secretion independently of GH receptor signaling in AgRP neurons by Sousa, Maria E., Gusmao, Daniela O., Santos, Willian O., Moriya, Henrique T., Lima, Felipe F., List, Edward O., Kopchick, John J., Donato, Jose

“…Growth hormone (GH) receptor (GHR) is abundantly expressed in neurons that co‐release the agouti‐related protein (AgRP) and neuropeptide Y (NPY) in the arcuate…”
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The increase in the number of amylin neurons in the medial preoptic area throughout the lactational period and its relationship with melanin-concentrating hormone by Duarte, Jessica Catharine Gomes, Ferreira, Jozelia Gomes Pacheco, Donato, José, Dobolyi, Arpád, Bittencourt, Jackson Cioni

“…The amylin and the melanin-concentrating hormone [MCH] are two peptides related to energetic homeostasis. During lactation, it is possible to locate neurons…”
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Growth Hormone Receptor Deletion Reduces the Density of Axonal Projections from Hypothalamic Arcuate Nucleus Neurons by Wasinski, Frederick, Furigo, Isadora C., Teixeira, Pryscila D.S., Ramos-Lobo, Angela M., Peroni, Cibele N., Bartolini, Paolo, List, Edward O., Kopchick, John J., Donato, Jose

“…•Formation of POMC and AgRP projections requires GH and leptin signaling.•POMC and AgRP projections are affected by LepR-specific GH receptor disruption.•AgRP…”
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