Search Results - "Donath, Marc Y."

Targeting inflammation in the treatment of type 2 diabetes: time to start by Donath, Marc Y.

“…Key Points Inflammation has an important role in the pathogenesis of type 2 diabetes and associated complications. Clinical studies have demonstrated that…”
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Type 1 diabetes: what is the role of autoimmunity in β cell death? by Donath, Marc Y

“…The current dogma of type 1 diabetes pathogenesis asserts that an autoimmune attack leads to the destruction of pancreatic β cells, with subsequent…”
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Inflammation in the Pathophysiology and Therapy of Cardiometabolic Disease by Donath, Marc Y, Meier, Daniel T, Böni-Schnetzler, Marianne

“…Abstract The role of chronic inflammation in the pathogenesis of type 2 diabetes mellitus and associated complications is now well established. Therapeutic…”
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Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity by Donath, Marc Y., Dalmas, Élise, Sauter, Nadine S., Böni-Schnetzler, Marianne

“…The role of the immune system is to restore functionality in response to stress. Increasing evidence shows that this function is not limited to insults by…”
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The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications by Herder, Christian, Dalmas, Elise, Böni-Schnetzler, Marianne, Donath, Marc Y

“…Patients with type 2 diabetes (T2D) exhibit chronic activation of the innate immune system in pancreatic islets, in insulin-sensitive tissues, and at sites of…”
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The Role of Inflammation in β-cell Dedifferentiation by Nordmann, Thierry M., Dror, Erez, Schulze, Friederike, Traub, Shuyang, Berishvili, Ekaterine, Barbieux, Charlotte, Böni-Schnetzler, Marianne, Donath, Marc Y.

“…Chronic inflammation impairs insulin secretion and sensitivity. β-cell dedifferentiation has recently been proposed as a mechanism underlying β-cell failure in…”
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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells by Ellingsgaard, Helga, Hauselmann, Irina, Schuler, Beat, Habib, Abdella M, Baggio, Laurie L, Meier, Daniel T, Eppler, Elisabeth, Bouzakri, Karim, Wueest, Stephan, Muller, Yannick D, Hansen, Ann Maria Kruse, Reinecke, Manfred, Konrad, Daniel, Gassmann, Max, Reimann, Frank, Halban, Philippe A, Gromada, Jesper, Drucker, Daniel J, Gribble, Fiona M, Ehses, Jan A, Donath, Marc Y

“…Helga Ellingsgaard et al . show that secretion of interleukin-6 by muscle in response to exercise, or injection of recombinant protein, increases the…”
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Cystine/Glutamate antiporter system xc- deficiency impairs macrophage glutathione metabolism and cytokine production by de Baat, Axel, Meier, Daniel T., Fontana, Adriano, Böni-Schnetzler, Marianne, Donath, Marc Y.

“…System x c - , encoded by Slc7a11 , is an antiporter responsible for exporting glutamate while importing cystine, which is essential for protein synthesis and…”
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Evidence for cephalic phase insulin release in humans: A systematic review and meta-analysis by Wiedemann, Sophia J., Rachid, Leila, Illigens, Ben, Böni-Schnetzler, Marianne, Donath, Marc Y.

“…The initial release of insulin in response to food stimuli acting on receptors in the head and oropharynx is called the cephalic phase of insulin secretion…”
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Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus by Larsen, Claus M, Faulenbach, Mirjam, Vaag, Allan, Vølund, Aage, Ehses, Jan A, Seifert, Burkhardt, Mandrup-Poulsen, Thomas, Donath, Marc Y

“…The expression of interleukin-1–receptor antagonist is reduced in pancreatic islets in type 2 diabetes, and high glucose concentrations induce interleukin-1β…”
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Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes by Larsen, Claus M, Faulenbach, Mirjam, Vaag, Allan, Ehses, Jan A, Donath, Marc Y, Mandrup-Poulsen, Thomas

“…OBJECTIVE: Interleukin (IL)-1 impairs insulin secretion and induces β-cell apoptosis. Pancreatic β-cell IL-1 expression is increased and interleukin-1 receptor…”
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Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes by CAVELTI-WEDER, Claudia, BABIANS-BRUNNER, Andrea, KELLER, Cornelia, STAHEL, Marc A, KURZ-LEVIN, Malaika, ZAYED, Hany, SOLINGER, Alan M, MANDRUP-POULSEN, Thomas, DINARELLO, Charles A, DONATH, Marc Y

“…Metabolic activation of the innate immune system governed by interleukin (IL)-1β contributes to β-cell failure in type 2 diabetes. Gevokizumab is a novel,…”
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Nivolumab-induced diabetes mellitus-a case report with literature review of the treatment options by Daetwyler, Eveline, Zippelius, Alfred, Danioth, Simona, Donath, Marc Y, Gut, Lara

“…Immune checkpoint inhibitor (ICI) treatment has become important for treating various cancer types, including metastatic renal cell carcinoma. However, ICI…”
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Cardiac evaluation in amiodarone-induced thyroid dysfunction with suspected cardiac ischemia?: a case report and review of the literature by Aubry, Yoann, Dosch, Michel, Donath, Marc Y

“…Amiodarone-induced thyroid dysfunction (AIT) is a side-effect associated with the use of Amiodarone for the treatment of refractory arrythmias. Resulting…”
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Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis by Traub, Shuyang, Meier, Daniel T., Schulze, Friederike, Dror, Erez, Nordmann, Thierry M., Goetz, Nicole, Koch, Norina, Dalmas, Elise, Stawiski, Marc, Makshana, Valmir, Thorel, Fabrizio, Herrera, Pedro L., Böni-Schnetzler, Marianne, Donath, Marc Y.

“…Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine…”
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Cytokine production by islets in health and diabetes: cellular origin, regulation and function by Donath, Marc Y, Böni-Schnetzler, Marianne, Ellingsgaard, Helga, Halban, Philippe A, Ehses, Jan A

“…Islets produce a variety of cytokines and chemokines in response to physiologic and pathologic stimulation by nutrients. The cellular source of these…”
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Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I by Böni-Schnetzler, Marianne, Boller, Simone, Debray, Sarah, Bouzakri, Karim, Meier, Daniel T, Prazak, Richard, Kerr-Conte, Julie, Pattou, Francois, Ehses, Jan A, Schuit, Frans C, Donath, Marc Y

“…Islets of patients with type 2 diabetes mellitus (T2DM) display features of an inflammatory process including elevated levels of the cytokine IL-1β, various…”
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Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge by Brykczynska, Urszula, Geigges, Marco, Wiedemann, Sophia J., Dror, Erez, Böni-Schnetzler, Marianne, Hess, Christoph, Donath, Marc Y., Paro, Renato

“…The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and…”
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Increased Number of Islet-Associated Macrophages in Type 2 Diabetes by EHSES, Jan A, PERREN, Aurel, FONTANA, Adriano, REINECKE, Manfred, HOMO-DELARCHE, Francoise, DONATH, Marc Y, EPPLER, Elisabeth, RIBAUX, Pascale, POSPISILIK, John A, MAOR-CAHN, Ranit, GUERIPEL, Xavier, ELLINGSGAARD, Helga, SCHNEIDER, Marten K. J, BIOLLAZ, Gregoire

“…Increased Number of Islet-Associated Macrophages in Type 2 Diabetes Jan A. Ehses 1 , Aurel Perren 2 , Elisabeth Eppler 3 , Pascale Ribaux 4 , John A…”
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Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing by Meier, Daniel T., Rachid, Leila, Wiedemann, Sophia J., Traub, Shuyang, Trimigliozzi, Kelly, Stawiski, Marc, Sauteur, Loïc, Winter, Denise V., Le Foll, Christelle, Brégère, Catherine, Guzman, Raphael, Odermatt, Alex, Böni-Schnetzler, Marianne, Donath, Marc Y.

“…Defective insulin processing is associated with obesity and diabetes. Prohormone convertase 1/3 (PC1/3) is an endopeptidase required for the processing of…”
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