Search Results - "Donath, M J"

Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII by LENTING, P. J, DONATH, M.-J. S. H, VAN MOURIK, J. A, MERTENS, K

“…The interaction between human factor IXa and factor VIII or its constituent units was investigated. Equilibrium binding studies were performed employing factor…”
Get full text

Biological activity of recombinant factor VIII variants lacking the central B-domain and the heavy-chain sequence Lys713-Arg740: discordant in vitro and in vivo activity by Mertens, K, Donath, M J, van Leen, R W, de Keyzer-Nellen, M J, Verbeet, M P, Klaasse Bos, J M, Leyte, A, van Mourik, J A

“…Recombinant factor VIII variants with overlapping deletions spanning the region Lys713-Ile1668 have been expressed in mammalian cells, and analysed for…”
Get more information

Characterization of des-(741-1668)-factor VIII, a single-chain factor VIII variant with a fusion site susceptible to proteolysis by thrombin and factor Xa by Donath, M J, de Laaf, R T, Biessels, P T, Lenting, P J, van de Loo, J W, van Mourik, J A, Voorberg, J, Mertens, K

“…A factor VIII variant has been characterized in which the heavy chain is directly fused to the light chain. Des-(741-1668)-factor VIII lacks the processing…”
Get full text

Cleavage at Arginine 145 in Human Blood Coagulation Factor IX Converts the Zymogen into a Factor VIII Binding Enzyme (∗) by Lenting, Peter J., ter Maat, Hans, Clijsters, Patrick P.F.M., Donath, Marie-José S.H., van Mourik, Jan A., Mertens, Koen

“…The transition of the factor IX zymogen into the enzyme factor IXaβ was investigated. For this purpose, the activation intermediate factors IXα and IXaα were…”
Get full text

Enhanced Thrombin Sensitivity of a Factor VIII-Heparin Cofactor II Hybrid by Voorberg, J, van Stempvoort, G, Bos, J M, Mertens, K, van Mourik, J A, Donath, M J

“…Generation of thrombin at a site of vascular injury is a key event in the arrest of bleeding. In addition to the conversion of fibrinogen into the insoluble…”
Get full text

The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX by Lenting, P J, van de Loo, J W, Donath, M J, van Mourik, J A, Mertens, K

“…In previous studies have shown that the interaction between factor IXa and VIII involves the light chain of factor VIII and that this interaction inhibited by…”
Get full text

Kinetics of factor VIII light-chain cleavage by thrombin and factor Xa. A regulatory role of the factor VIII heavy-chain region Lys713-Arg740 by Donath, M J, Lenting, P J, Van Mourik, J A, Mertens, K

“…Activation and limited proteolysis of factor VIII have been investigated with respect to the role of the heavy-chain region Lys713-Arg740. The kinetics of…”
Get full text

Transcriptional regulation of retinoic acid receptor beta in retinoic acid-sensitive and -resistant P19 embryocarcinoma cells by Kruyt, F A, van den Brink, C E, Defize, L H, Donath, M J, Kastner, P, Kruijer, W, Chambon, P, van der Saag, P T

“…As in other embryocarcinoma (EC) cell lines retinoic acid (RA) rapidly induces expression of the nuclear retinoic acid receptor (RAR) beta in murine P19 EC…”
Get more information