Search Results - "Donath, José"

Cyclic AMP Raises Intracellular Ca2+ in Human Megakaryocytes Independent of Protein Kinase A by den Dekker, Els, Heemskerk, Johan W.M, Gorter, Gertie, van der Vuurst, Hans, Donath, José, Kroner, Christine, Mikoshiba, Katsuhiko, Akkerman, Jan-Willem N

“…The immature megakaryoblastic cell line MEG-01 responds to iloprost with an increase in cytosolic Ca and cAMP. The Ca response is almost absent in CHRF-288–11…”
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Signal Transduction Through Trimeric G Proteins in Megakaryoblastic Cell Lines by van der Vuurst, Hans, van Willigen, Gijsbert, van Spronsen, Anke, Hendriks, Maaike, Donath, Jose, Akkerman, Jan-Willem N

“…The biogenesis of trimeric G proteins was investigated by measurement of the expression of alpha-subunits in the megakaryoblastic cell lines MEG-01, DAMI, and…”
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Cleavage at Arginine 145 in Human Blood Coagulation Factor IX Converts the Zymogen into a Factor VIII Binding Enzyme (∗) by Lenting, Peter J., ter Maat, Hans, Clijsters, Patrick P.F.M., Donath, Marie-José S.H., van Mourik, Jan A., Mertens, Koen

“…The transition of the factor IX zymogen into the enzyme factor IXaβ was investigated. For this purpose, the activation intermediate factors IXα and IXaα were…”
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Enhanced Thrombin Sensitivity of a Factor VIII-Heparin Cofactor II Hybrid by Voorberg, J, van Stempvoort, G, Bos, J M, Mertens, K, van Mourik, J A, Donath, M J

“…Generation of thrombin at a site of vascular injury is a key event in the arrest of bleeding. In addition to the conversion of fibrinogen into the insoluble…”
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Cyclic AMP raises intracellular Ca(2+) in human megakaryocytes independent of protein kinase A by den Dekker, Els, Heemskerk, Johan W M, Gorter, Gertie, van der Vuurst, Hans, Donath, José, Kroner, Christine, Mikoshiba, Katsuhiko, Akkerman, Jan-Willem N

“…The immature megakaryoblastic cell line MEG-01 responds to iloprost with an increase in cytosolic Ca(2+) and cAMP. The Ca(2+) response is almost absent in…”
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Inhibition of Platelet Integrin α IIb β 3 by Peptides That Interfere With Protein Kinases and the β 3 Tail by Hers, Ingeborg, Donath, José, Litjens, Pieter E. M. H., van Willigen, Gijsbert, Akkerman, Jan-Willem N.

“…Abstract —α-Thrombin stimulation of human platelets initiates inside-out signaling to integrin α IIb β 3 (glycoprotein IIb/IIIa), resulting in the exposure of…”
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The role of cleavage of the light chain at positions Arg1689 or Arg1721 in subunit interaction and activation of human blood coagulation factor VIII by Donath, M S, Lenting, P J, van Mourik, J A, Mertens, K

“…The role of Factor VIII light chain cleavage in Factor VIII activation and subunit interaction was investigated. Purified Factor VIII was dissociated into its…”
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The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX by Lenting, P J, van de Loo, J W, Donath, M J, van Mourik, J A, Mertens, K

“…In previous studies have shown that the interaction between factor IXa and VIII involves the light chain of factor VIII and that this interaction inhibited by…”
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Cyclic AMP Raises Intracellular Ca 2+ in Human Megakaryocytes Independent of Protein Kinase A by den Dekker, Els, Heemskerk, Johan W.M., Gorter, Gertie, van der Vuurst, Hans, Donath, José, Kroner, Christine, Mikoshiba, Katsuhiko, Akkerman, Jan-Willem N.

“…The immature megakaryoblastic cell line MEG-01 responds to iloprost with an increase in cytosolic Ca 2+ and cAMP. The Ca 2+ response is almost absent in…”
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Differential Involvement of Tyrosine and Serine/Threonine Kinases in Platelet Integrin α IIb β 3 Exposure by Hers, Ingeborg, Donath, José, van Willigen, Gijsbert, Akkerman, Jan Willem N.

“…Abstract —The relative contributions of protein tyrosine kinases (PTKs) and protein kinase C isoenzymes (PKCs), a family of serine/threonine kinases, in…”
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Identification of α-Subunits of Trimeric GTP-Binding Proteins in Human Platelets by RT-PCR by Vanwilligen, G., Donath, J., Lapetina, E.G., Akkerman, J.W.N.

“…In a search for new α-subunits of trimeric GTP-binding proteins in human platelets, we prepared leucocyte-free platelet concentrates and analyzed total RNA for…”
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Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII by LENTING, P. J, DONATH, M.-J. S. H, VAN MOURIK, J. A, MERTENS, K

“…The interaction between human factor IXa and factor VIII or its constituent units was investigated. Equilibrium binding studies were performed employing factor…”
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Inhibition of Platelet Integrin αIIbβ3 by Peptides That Interfere With Protein Kinases and the β3 Tail by Hers, Ingeborg, Donath, José, Litjens, Pieter E. M. H, van Willigen, Gijsbert, Akkerman, Jan-Willem N

“…α-Thrombin stimulation of human platelets initiates inside-out signaling to integrin αIIbβ3 (glycoprotein IIb/IIIa), resulting in the exposure of ligand…”
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Differential involvement of tyrosine and serine/threonine kinases in platelet integrin alpha(IIb)beta(3) exposure by Hers, Ingeborg, Donath, Jose, Gijsbert van Willigen, Akkerman, Jan Willem N

“…The relative contributions of protein tyrosine kinases (PTKs) and protein kinase C isoenzymes (PKCs), a family of serine/threonine kinases, in integrin…”
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The Role of Cleavage of the Light Chain at Positions Arg or Arg in Subunit Interaction and Activation of Human Blood Coagulation Factor VIII by Marie-José S. H. Donath, Peter J. Lenting, Jan A. van Mourik, Koen Mertens

“…The role of Factor VIII light chain cleavage in Factor VIII activation and subunit interaction was investigated. Purified Factor VIII was dissociated into its…”
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Inhibition of platelet integrin (alpba)IIb(beta)3 by peptides that interfere with protein kinases and the (beta)3 tail by Hers, Ingeborg, Donath, Jose, Pieter E M H Litjens, Gijsbert van Willigen, Akkerman, Jan-Willem N

“…alpha-Thrombin stimulation of human platelets initiates inside-out signaling to integrin alpha(IIb)beta(3) (glycoprotein IIb/IIIa), resulting in the exposure…”
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Acute myeloid leukemias with chromosomal abnormalities involving the 21q22 region identified by their in vitro responsiveness to interleukin-5 by Touw, I, Donath, J, Pouwels, K, van Buitenen, C, Schipper, P, Santini, V, Hagemeijer, A, Löwenberg, B, Delwel, R

“…Among 52 patients diagnosed as acute myeloid leukemia (AML), nine cases were found in which interleukin-5 (IL-5) induced a proliferative response in the…”
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Transcriptional regulation of retinoic acid receptor beta in retinoic acid-sensitive and -resistant P19 embryocarcinoma cells by Kruyt, F A, van den Brink, C E, Defize, L H, Donath, M J, Kastner, P, Kruijer, W, Chambon, P, van der Saag, P T

“…As in other embryocarcinoma (EC) cell lines retinoic acid (RA) rapidly induces expression of the nuclear retinoic acid receptor (RAR) beta in murine P19 EC…”
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Kinetics of Factor VIII Light‐Chain Cleavage by Thrombin and Factor Xa by Donath, Marie‐José S. H., Lenting, Peter J., Mourik, Jan A., Mertens, Koen

“…Activation and limited proteolysis of factor VIII have been investigated with respect to the role of the heavy‐chain region Lys713‐Arg740. The kinetics of…”
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Kinetics of factor VIII light-chain cleavage by thrombin and factor Xa. A regulatory role of the factor VIII heavy-chain region Lys713-Arg740 by Donath, M J, Lenting, P J, Van Mourik, J A, Mertens, K

“…Activation and limited proteolysis of factor VIII have been investigated with respect to the role of the heavy-chain region Lys713-Arg740. The kinetics of…”
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