Search Results - "Donaldson, Ken"
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Global association of air pollution and heart failure: a systematic review and meta-analysis
Published in The Lancet (British edition) (21-09-2013)“…Summary Background Acute exposure to air pollution has been linked to myocardial infarction, but its effect on heart failure is uncertain. We did a systematic…”
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Nanotoxicity: challenging the myth of nano-specific toxicity
Published in Current opinion in biotechnology (01-08-2013)“…Graphical abstract…”
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A short history of the toxicology of inhaled particles
Published in Particle and fibre toxicology (06-05-2012)“…Particle toxicology arose in order to understand the mechanisms of adverse effects of 3 major particle types that had historically exerted the greatest toll of…”
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Pulmonary toxicity of carbon nanotubes and asbestos — Similarities and differences
Published in Advanced drug delivery reviews (01-12-2013)“…Carbon nanotubes are a valuable industrial product but there is potential for human pulmonary exposure during production and their fibrous shape raises the…”
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Use of back-scatter electron signals to visualise cell/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo
Published in Particle and fibre toxicology (28-08-2012)“…Frustrated phagocytosis has been stated as an important factor in the initiation of an inflammatory response after fibre exposure. The length of fibrous…”
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Expert position paper on air pollution and cardiovascular disease
Published in European heart journal (07-01-2015)Get full text
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Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma
Published in Particle and fibre toxicology (22-03-2010)“…The unique hazard posed to the pleural mesothelium by asbestos has engendered concern in potential for a similar risk from high aspect ratio nanoparticles…”
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Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes
Published in Particle and fibre toxicology (06-09-2011)“…Large production volumes of zinc oxide nanoparticles (ZnONP) might be anticipated to pose risks, of accidental inhalation in occupational and even in consumer…”
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The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area
Published in Occupational and environmental medicine (London, England) (01-09-2007)“…Objective: Rats exposed to high airborne mass concentrations of low-solubility low-toxicity particles (LSLTP) have been reported to develop lung disease such…”
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The Biologically Effective Dose in Inhalation Nanotoxicology
Published in Accounts of chemical research (19-03-2013)“…In all branches of toxicology, the biologically effective dose (BED) is thefraction of the total dose of a toxin that actually drives any toxic effect…”
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Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles
Published in Toxicological sciences (01-04-2012)“…The toxicology of nanoparticles (NPs) is an area of intense investigation that would be greatly aided by improved understanding of the relationship between NP…”
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Proinflammogenic Effects of Low-Toxicity and Metal Nanoparticles In Vivo and In Vitro: Highlighting the Role of Particle Surface Area and Surface Reactivity
Published in Inhalation toxicology (01-01-2007)“…Different particle types cause excessive lung inflammation that is thought to play a role in the various types of pathology they produce. Recently attention…”
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The mechanism of pleural inflammation by long carbon nanotubes: interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells
Published in Particle and fibre toxicology (03-04-2012)“…Carbon nanotubes (CNT) are high aspect ratio nanoparticles with diameters in the nanometre range but lengths extending up to hundreds of microns. The…”
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Use of silver nanowires to determine thresholds for fibre length-dependent pulmonary inflammation and inhibition of macrophage migration in vitro
Published in Particle and fibre toxicology (02-12-2012)“…The objective of this study was to examine the threshold fibre length for the onset of pulmonary inflammation after aspiration exposure in mice to four…”
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Length-Dependent Retention of Carbon Nanotubes in the Pleural Space of Mice Initiates Sustained Inflammation and Progressive Fibrosis on the Parietal Pleura
Published in The American journal of pathology (01-06-2011)“…The fibrous shape of carbon nanotubes (CNTs) raises concern that they may pose an asbestos-like inhalation hazard, leading to the development of diseases,…”
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The potential risks of nanomaterials: a review carried out for ECETOC
Published in Particle and fibre toxicology (14-08-2006)“…During the last few years, research on toxicologically relevant properties of engineered nanoparticles has increased tremendously. A number of international…”
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Comparison of cellular toxicity caused by ambient ultrafine particles and engineered metal oxide nanoparticles
Published in Particle and fibre toxicology (19-03-2015)“…The development of nanotechnology has spurred concerns about the health effects of exposure to nanoparticles (NPs) and ultrafine particles (UFPs)…”
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The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma
Published in Toxicological sciences (01-08-2012)“…Suspicion has been raised that high aspect ratio nanoparticles or nanofibers might possess asbestos-like pathogenicity. The pleural space is a specific target…”
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Inhaled nanoparticles and lung cancer - what we can learn from conventional particle toxicology
Published in Swiss medical weekly (2012)“…Manufactured nanoparticles (MNP) represent a growth area in industry where their interesting and useful properties bestow advantage over conventional particles…”
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Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy
Published in Particle and fibre toxicology (06-10-2005)“…The rapid proliferation of many different engineered nanomaterials (defined as materials designed and produced to have structural features with at least one…”
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