Search Results - "Donaldson, Kelly H"

Biarylaniline Phenethanolamines as Potent and Selective β3 Adrenergic Receptor Agonists by Uehling, David E, Shearer, Barry G, Donaldson, Kelly H, Chao, Esther Y, Deaton, David N, Adkison, Kim K, Brown, Kathleen K, Cariello, Neal F, Faison, Walter L, Lancaster, Mary E, Lin, Jasmine, Hart, Robert, Milliken, Tula O, Paulik, Mark A, Sherman, Bryan W, Sugg, Elizabeth E, Cowan, Conrad

“…The synthesis of a series of phenethanolamine aniline agonists that contain an aniline ring on the right-hand side of the molecule substituted at the meta…”
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Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors by Rheault, Tara R., Caferro, Thomas R., Dickerson, Scott H., Donaldson, Kelly H., Gaul, Michael D., Goetz, Aaron S., Mullin, Robert J., McDonald, Octerloney B., Petrov, Kimberly G., Rusnak, David W., Shewchuk, Lisa M., Spehar, Glenn M., Truesdale, Anne T., Vanderwall, Dana E., Wood, Edgar R., Uehling, David E.

“…Two new series of potent and selective dual EGFR/ErbB-2 kinase inhibitors derived from novel thienopyrimidine cores have been identified. Isomeric…”
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6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases by Wood, Edgar R, Shewchuk, Lisa M, Ellis, Byron, Brignola, Perry, Brashear, Ronald L, Caferro, Thomas R, Dickerson, Scott H, Dickson, Hamilton D, Donaldson, Kelly H, Gaul, Michael, Griffin, Robert J, Hassell, Anne M, Keith, Barry, Mullin, Robert, Petrov, Kimberly G, Reno, Michael J, Rusnak, David W, Tadepalli, Sarva M, Ulrich, John C, Wagner, Craig D, Vanderwall, Dana E, Waterson, Alex G, Williams, Jon D, White, Wendy L, Uehling, David E

“…Analysis of the x-ray crystal structure of mono-substituted acetylenic thienopyrimidine 6 complexed with the ErbB family enzyme ErbB-4 revealed a covalent bond…”
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Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties by Rheault, Tara R., Donaldson, Kelly H., Badiang-Alberti, Jennifer G., Davis-Ward, Ronda G., Andrews, C. Webb, Bambal, Ramesh, Jackson, Jeffrey R., Cheung, Mui

“…Potent inhibitors of PLK1 with acceptable solubility, mouse iv clearance, and reduced CYP450 inhibition were identified. Drug-like properties were improved…”
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Synthesis and Evaluation of Potent and Selective β3 Adrenergic Receptor Agonists Containing Acylsulfonamide, Sulfonylsulfonamide, and Sulfonylurea Carboxylic Acid Isosteres by Uehling, David E, Donaldson, Kelly H, Deaton, David N, Hyman, Clifton E, Sugg, Elizabeth E, Barrett, David G, Hughes, Robert G, Reitter, Barbara, Adkison, Kim K, Lancaster, Mary E, Lee, Frank, Hart, Robert, Paulik, Mark A, Sherman, Bryan W, True, Timothy, Cowan, Conrad

“…Starting from phenethanolamine aniline leads 3a and 3b, we have identified a series of functionally potent and selective β3 adrenergic receptor (AR) agonists…”
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Convenient synthesis of heteroaryl-linked benzimidazoles via microwave-assisted boronate ester formation by Rheault, Tara R., Donaldson, Kelly H., Cheung, Mui

“…N-Substituted 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1 H-benzimidazoles were conveniently accessed via microwave-assisted synthesis. Subsequent…”
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Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres by Uehling, David E, Donaldson, Kelly H, Deaton, David N, Hyman, Clifton E, Sugg, Elizabeth E, Barrett, David G, Hughes, Robert G, Reitter, Barbara, Adkison, Kim K, Lancaster, Mary E, Lee, Frank, Hart, Robert, Paulik, Mark A, Sherman, Bryan W, True, Timothy, Cowan, Conrad

“…Starting from phenethanolamine aniline leads 3a and 3b, we have identified a series of functionally potent and selective beta(3) adrenergic receptor (AR)…”
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6-Ethynylthieno[3,2-d]- and 6-ethynyithieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases by Wood, Edgar R, Shewchuk, Lisa M, Ellis, Byron, Brignola, Perry, Brashear, Ronald L, Caferro, Thomas R, Dickerson, Scott H, Dickson, Hamilton D, Donaldson, Kelly H, Gaul, Michael, Griffin, Robert J, Hassell, Anne M, Keith, Barry, Mullin, Robert, Petrov, Kimberly G, Reno, Michael J, Rusnak, David W, Tadepalli, Sarva M, Ulrich, John C, Wagner, Craig D, Vanderwall, Dana E, Waterson, Alex G, Williams, Jon D, White, Wendy L, Uehling, David E

“…Analysis of the x-ray crystal structure of mono-substituted acetylenic thienopyrimidine 6 complexed with the ErbB family enzyme ErbB-4 revealed a covalent bond…”
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Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists by Uehling, David E, Shearer, Barry G, Donaldson, Kelly H, Chao, Esther Y, Deaton, David N, Adkison, Kim K, Brown, Kathleen K, Cariello, Neal F, Faison, Walter L, Lancaster, Mary E, Lin, Jasmine, Hart, Robert, Milliken, Tula O, Paulik, Mark A, Sherman, Bryan W, Sugg, Elizabeth E, Cowan, Conrad

“…The synthesis of a series of phenethanolamine aniline agonists that contain an aniline ring on the right-hand side of the molecule substituted at the meta…”
Get full text

Biarylaniline Phenethanolamines as Potent and Selective β 3 Adrenergic Receptor Agonists by Uehling, David E., Shearer, Barry G., Donaldson, Kelly H., Chao, Esther Y., Deaton, David N., Adkison, Kim K., Brown, Kathleen K., Cariello, Neal F., Faison, Walter L., Lancaster, Mary E., Lin, Jasmine, Hart, Robert, Milliken, Tula O., Paulik, Mark A., Sherman, Bryan W., Sugg, Elizabeth E., Cowan, Conrad

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Synthesis and Evaluation of Potent and Selective β 3 Adrenergic Receptor Agonists Containing Acylsulfonamide, Sulfonylsulfonamide, and Sulfonylurea Carboxylic Acid Isosteres by Uehling, David E., Donaldson, Kelly H., Deaton, David N., Hyman, Clifton E., Sugg, Elizabeth E., Barrett, David G., Hughes, Robert G., Reitter, Barbara, Adkison, Kim K., Lancaster, Mary E., Lee, Frank, Hart, Robert, Paulik, Mark A., Sherman, Bryan W., True, Timothy, Cowan, Conrad

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The synthesis of cis ‐6,12‐Diaryl‐6 H ,12 H ‐dibenzo[ b,f ][1,5]dithiocin‐6,12‐imine and cis ‐6,12‐Diphenyl‐6,12‐epoxy‐6 H ,12 H ‐dibenzo[ b,f ][1,5]dithiocin by Brieaddy, Lawrence E., Donaldson, Kelly H.

“…When treated with concentrated hydrochloric acid or heated beyond its melting point, the versatile thioimine 2 2‐mercaptobenzhydrylidenamine was unexpectedly…”
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The synthesis of cis-6,12-Diaryl-6H,12H-dibenzo[b,f][1,5]dithiocin-6,12-imine and cis-6,12-Diphenyl-6,12-epoxy-6H,12H-dibenzo[b,f][1,5]dithiocin by Brieaddy, Lawrence E., Donaldson, Kelly H.

“…When treated with concentrated hydrochloric acid or heated beyond its melting point, the versatile thioimine 2 2‐mercaptobenzhydrylidenamine was unexpectedly…”
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