Search Results - "Donald J. Wolfgeher"

Biomarkers of Pediatric Cataracts: A Proteomics Analysis of Aqueous Fluid by Theophanous, Christos N, Wolfgeher, Donald J, Farooq, Asim V, Hilkert Rodriguez, Sarah

“…Cataracts are among the most common causes of childhood vision loss worldwide. This study seeks to identify differentially expressed proteins in the aqueous…”
Get full text

CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex by Liu, Weihan, Kurkewich, Jeffrey L., Stoddart, Angela, Khan, Saira, Anandan, Dhivyaa, Gaubil, Alexandre N., Wolfgeher, Donald J., Jueng, Lia, Kron, Stephen J., McNerney, Megan E.

“…CUX1 is a homeodomain-containing transcription factor that is essential for the development and differentiation of multiple tissues. CUX1 is recurrently…”
Get full text

O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors by Efimova, Elena V, Appelbe, Oliver K, Ricco, Natalia, Lee, Steve S-Y, Liu, Yue, Wolfgeher, Donald J, Collins, Tamica N, Flor, Amy C, Ramamurthy, Aishwarya, Warrington, Sara, Bindokas, Vytautas P, Kron, Stephen J

“…The metabolic reprogramming associated with characteristic increases in glucose and glutamine metabolism in advanced cancer is often ascribed to answering a…”
Get full text

Genomic studies controvert the existence of the CUX1 p75 isoform by Krishnan, Manisha, Senagolage, Madhavi D., Baeten, Jeremy T., Wolfgeher, Donald J., Khan, Saira, Kron, Stephen J., McNerney, Megan E.

“…CUX1 , encoding a homeodomain-containing transcription factor, is recurrently deleted or mutated in multiple tumor types. In myeloid neoplasms, CUX1 deletion…”
Get full text

Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells by Liu, Yue, Pagacz, Joanna, Wolfgeher, Donald J, Bromerg, Kenneth D, Gorman, Jacob V, Kron, Stephen J

“…BackgroundImmune tolerance contributes to resistance to conventional cancer therapies such as radiation. Radiotherapy induces immunogenic cell death, releasing…”
Get full text

A method for whole protein isolation from human cranial bone by Lyon, Sarah M., Mayampurath, Anoop, Rogers, M. Rose, Wolfgeher, Donald J., Fisher, Sean M., Volchenboum, Samuel L., He, Tong-Chuan, Reid, Russell R.

“…The presence of the dense hydroxyapatite matrix within human bone limits the applicability of conventional protocols for protein extraction. This has hindered…”
Get full text

Proteomic analysis defines the interactome of telomerase in the protozoan parasite, Trypanosoma brucei by Davis, Justin A, Reyes, Andres V, Nitika, Saha, Arpita, Wolfgeher, Donald J, Xu, Shou-Ling, Truman, Andrew W, Li, Bibo, Chakrabarti, Kausik

“…Telomerase is a ribonucleoprotein enzyme responsible for maintaining the telomeric end of the chromosome. The telomerase enzyme requires two main components to…”
Get full text

Genetic analysis of Hsp70 phosphorylation sites reveals a role in Candida albicans cell and colony morphogenesis by Weissman, Ziva, Pinsky, Mariel, Wolfgeher, Donald J., Kron, Stephen J., Truman, Andrew W., Kornitzer, Daniel

“…Heat shock proteins are best known for their role as chaperonins involved in general proteostasis, but they can also participate in specific cellular…”
Get full text

Epidermal stratification requires retromer-mediated desmoglein-1 recycling by Hegazy, Marihan, Koetsier, Jennifer L., Huffine, Amber L., Broussard, Joshua A., Godsel, Brendan M., Cohen-Barak, Eran, Sprecher, Eli, Wolfgeher, Donald J., Kron, Stephen J., Godsel, Lisa M., Green, Kathleen J.

“…Sorting transmembrane cargo is essential for tissue development and homeostasis. However, mechanisms of intracellular trafficking in stratified epidermis are…”
Get full text

Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization by Liu, Yue, Betori, Rick C, Pagacz, Joanna, Frost, Grant B, Efimova, Elena V, Wu, Ding, Wolfgeher, Donald J, Bryan, Tracy M, Cohen, Scott B, Scheidt, Karl A, Kron, Stephen J

“…Beyond synthesizing telomere repeats, the telomerase reverse transcriptase (TERT) also serves multiple other roles supporting cancer growth. Blocking…”
Get more information

Pseudomonas syringae effector HopZ3 suppresses the bacterial AvrPto1-tomato PTO immune complex via acetylation by Jeleńska, Joanna, Lee, Jiyoung, Manning, Andrew J, Wolfgeher, Donald J, Ahn, Youngjoo, Walters-Marrah, George, Lopez, Ivan E, Garcia, Lissette, McClerklin, Sheri A, Michelmore, Richard W, Kron, Stephen J, Greenberg, Jean T

“…The plant pathogen Pseudomonas syringae secretes multiple effectors that modulate plant defenses. Some effectors trigger defenses due to specific recognition…”
Get full text

Simple strategies to enhance discovery of acetylation post-translational modifications by quadrupole-orbitrap LC-MS/MS by Manning, Andrew J., Lee, Jiyoung, Wolfgeher, Donald J., Kron, Stephen J., Greenberg, Jean T.

“…Enzyme-dependent post-translational modifications (PTMs) mediate the cellular regulation of proteins and can be discovered using proteomics. However, even…”
Get full text

Abstract 2697: Alterations in the HSP70 interactome are induced by overexpression of MUC1 in pancreatic cancer by Nitika, ., Wolfgeher, Donald J., Mukherjee, Pinku, Truman, Andrew W.

“…Heat Shock Protein 70 (HSP70) is an evolutionarily well-conserved molecular chaperone involved in several cellular processes such as folding of proteins,…”
Get full text

Abstract 2966: Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells by Liu, Yue, Pagacz, Joanna, Wolfgeher, Donald J., Kron, Stephen J.

“…Diverse conventional cancer therapies, including genotoxic agents and cell cycle or cell division-targeting drugs, can trigger cancer cell senescence…”
Get full text

Abstract 2874: Cancer metabolism in radiation resistance: Complementary roles of O-GlcNAc transferase and PARP1 by Efimova, Elena E., Averbek, Sera, Wolfgeher, Donald J., Wu, Ding, Liu, Yue, Kron, Stephen J.

“…The efficacy of image-guided radiotherapy (RT) has been linked to directing increased chromosomal double strand breaks (DSBs) to tumor cells while sparing…”
Get full text

Pseudomonas syringae effector HopZ3 suppresses the bacterial AvrPto1–tomato PTO immune complex via acetylation by Joanna Jeleńska, Jiyoung Lee, Andrew J. Manning, Donald J. Wolfgeher, Youngjoo Ahn, George Walters-Marrah, Ivan E. Lopez, Lissette Garcia, Sheri A. McClerklin, Richard W. Michelmore, Stephen J. Kron, Jean T. Greenberg

“…The plant pathogen Pseudomonas syringae secretes multiple effectors that modulate plant defenses. Some effectors trigger defenses due to specific recognition…”
Get full text

Abstract 3505: Tumor radiosensitization by suppression of hexosamine biosynthetic pathway by Efimova, Elena V., Appelbe, Oliver K., Lee, Steve Seung-Young, Ricco, Natalia, Ramamarthy, Aishwarya, Rymut, Nicolas, Collins, Tamica, Wolfgeher, Donald J., Warrington, Sara, Kron, Stephen J.

“…The elevation of glucose and glutamine metabolism characteristic of cancer has been ascribed to increased demand for metabolic intermediates that provide…”
Get full text

Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa by Patel, Nachiket J, Zaborina, Olga, Wu, Licheng, Wang, Yingmin, Wolfgeher, Donald J, Valuckaite, Vesta, Ciancio, Mae J, Kohler, Jonathan E, Shevchenko, Olga, Colgan, Sean P, Chang, Eugene B, Turner, Jerrold R, Alverdy, John C

“…Human intestinal epithelial cell monolayers (Caco-2) subjected to hypoxia and reoxygenation release soluble factors into the apical medium that activate the…”
Get more information