Search Results - "Donald, P R"

Randomized Pilot Trial of Eight Weeks of Bedaquiline (TMC207) Treatment for Multidrug-Resistant Tuberculosis: Long-Term Outcome, Tolerability, and Effect on Emergence of Drug Resistance by DIACON, A. H, DONALD, P. R, LOUNIS, N, MEYVISCH, P, ANDRIES, K, MCNEELEY, D. F, PYM, A, GROBUSCH, M, PATIENTIA, R. F, MAHANYELE, R, BANTUBANI, N, NARASIMOOLOO, R, DE MAREZ, T, VAN HEESWIJK, R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients by DIACON, A. H, DAWSON, R, HANEKOM, M, NARUNSKY, K, VENTER, A, HITTER, N, GEITER, L. J, WELLS, C. D, PACCALY, A. J, DONALD, P. R

“…BACKGROUND: Delamanid (OPC-67683) is a novel mycolic acid biosynthesis inhibitor active against Mycobacterium tuberculosis at a low minimum inhibitory…”
Get full text

Early Bactericidal Activity of High-Dose Rifampin in Patients with Pulmonary Tuberculosis Evidenced by Positive Sputum Smears by DIACON, A. H, PATIENTIA, R. F, VENTER, A, VAN HELDEN, P. D, SMITH, P. J, MCILLERON, H, MARITZ, J. S, DONALD, P. R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Early Bactericidal Activity and Pharmacokinetics of the Diarylquinoline TMC207 in Treatment of Pulmonary Tuberculosis by RUSTOMJEE, R, DIACON, A. H, KEPT, A, DE BEULE, K, DONALD, P. R, MCNEELEY, D. F, ALIEN, J, VENTER, A, REDDY, C, PATIENTIA, R. F, MTHIYANE, T. C. P, DE MAREZ, T, VAN HEESWIJK, R, KERSTENS, R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Cerebrospinal fluid concentrations of antituberculosis agents in adults and children by Donald, P.R

“…Summary Tuberculous meningitis (TBM) causes a devastating morbidity and mortality in adults and children. Even in patients presenting at an early stage of…”
Get full text

Pharmacokinetics of Rifampin, Isoniazid, Pyrazinamide, and Ethambutol in Infants Dosed According to Revised WHO-Recommended Treatment Guidelines by Bekker, A, Schaaf, H S, Draper, H R, van der Laan, L, Murray, S, Wiesner, L, Donald, P R, McIlleron, H M, Hesseling, A C

“…There are limited pharmacokinetic data for use of the first-line antituberculosis drugs during infancy (<12 months of age), when drug disposition may differ…”
Get full text

Pharmacokinetics of Isoniazid, Rifampin, and Pyrazinamide in Children Younger than Two Years of Age with Tuberculosis: Evidence for Implementation of Revised World Health Organization Recommendations by THEE, S, SEDDON, J. A, DONALD, P. R, SEIFART, H. I, WERELY, C. J, HESSELING, A. C, ROSENKRANZ, B, ROLL, S, MAGDORF, K, SCHAAF, H. S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

The North American contribution to our knowledge of childhood tuberculosis and its epidemiology by Donald, P. R.

“…Although it comprises a substantial proportion of the tuberculosis (TB) burden, particularly in developing communities, childhood TB was until recently largely…”
Get full text

The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era [State of the Art] by MARAIS, B. J, GIE, R. P, SCHAAF, H. S, HESSELING, A. C, OBIHARA, C. C, STARKE, J. J, ENARSON, T. D. A, DONALD, P. R, BEYERS, N

“…The pre-chemotherapy literature documented the natural history of tuberculosis in childhood. These disease descriptions remain invaluable for guiding public…”
Get full text

Droplets, dust and guinea pigs: an historical review of tuberculosis transmission research, 1878-1940 by Donald, P. R., Diacon, A. H., Lange, C., Demers, A-M., von Groote-Biddlingmeier, F., Nardell, E.

“…The transmission of tuberculosis (TB) occurs mainly via inhalation of airborne droplet nuclei; however, the precise details of this process remain uncertain…”
Get full text

Time to liquid culture positivity can substitute for colony counting on agar plates in early bactericidal activity studies of antituberculosis agents by Diacon, A.H., Maritz, J.S., Venter, A., van Helden, P.D., Dawson, R., Donald, P.R.

“…The measurement of early bactericidal activity (EBA) is the first step in the clinical investigation of antituberculosis agents. EBA is determined by…”
Get full text

Pharmacokinetics of Ethionamide in Children by THEE, S, SEIFART, H. I, ROSENKRANZ, B, HESSELING, A. C, MAGDORF, K, DONALD, P. R, SCHAAF, H. S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

The chemotherapy of osteo-articular tuberculosis with recommendations for treatment of children by Donald, P.R

“…Summary Objective To review literature regarding osteo-articular tuberculosis (OATB) and make recommendations made for the chemotherapy of children. Methods…”
Get full text

Time to detection of the growth of Mycobacterium tuberculosis in MGIT 960 for determining the early bactericidal activity of antituberculosis agents by Diacon, A. H, Maritz, J. S, Venter, A, van Helden, P. D, Andries, K, McNeeley, D. F, Donald, P. R

“…Evaluation of early bactericidal activity (EBA) by the determination of a fall in viable colony-forming units (CFU) of Mycobacterium tuberculosis in sputum is…”
Get full text

Antituberculosis drugs in children by Schaaf, HS, Garcia-Prats, AJ, Donald, PR

“…Tuberculosis (TB) remains a global threat to children, as it often goes undiagnosed and leads to high morbidity and mortality. Active contact tracing leading…”
Get full text

The clinical epidemiology of childhood pulmonary tuberculosis: a critical review of literature from the pre-chemotherapy era [State of the Art] by MARAIS, B. J, GIE, R. P, SCHAAF, H. S, HESSELING, A. C, OBIHARA, C. C, NELSON, L. J, ENARSON, T. D. A, DONALD, P. R, BEYERS, N

“…The pre-chemotherapy literature represents an impressive body of evidence that clarifies important epidemiological concepts in childhood tuberculosis. Reports…”
Get full text

Ethambutol dosage for the treatment of children: literature review and recommendations [Review Article] by Donald, P R, Maher, D, Maritz, J S, Qazi, S

“…The currently recommended daily dose of ethambutol (EMB) for the treatment of tuberculosis (TB) in children varies from a maximum daily dose of 15 mg/kg body…”
Get full text

Rifampicin-monoresistant Mycobacterium tuberculosis disease among children in Cape Town, South Africa by Dramowski, A., Morsheimer, M. M., Jordaan, A. M., Victor, T. C., Donald, P. R., Schaaf, H. S.

“…SETTING: Tygerberg Children's Hospital (TCH) and Brooklyn Chest Hospital (BCH), South Africa.OBJECTIVES: To describe paediatric cases of rifampicin (RMP)…”
Get full text

The influence of dose and N-acetyltransferase-2 (NAT2) genotype and phenotype on the pharmacokinetics and pharmacodynamics of isoniazid by DONALD, P. R, PARKIN, D. P, SEIFART, H. I, SCHAAF, H. S, VAN HELDEN, P. D, WERELY, C. J, SIRGEL, F. A, VENTER, A, MARITZ, J. S

“…This study evaluated the pharmacokinetics of isoniazid (INH) associated with optimal early bactericidal activity (EBA), defined as 90% of the maximum EBA…”
Get full text

Requirements for the clinical evaluation of new anti-tuberculosis agents in children by Donald, P. R., Ahmed, A., Burman, W. J., Cotton, M. F., Graham, S. M., Mendel, C., McIlleron, H., Mac Kenzie, W. R., Nachman, S., Schaaf, H. S., Starke, J. R., Wingfield, C., Hesseling, A. C.

“…The ultimate goal of evidence-based drug treatment is to produce a desired pharmacological response in a predictable manner and also to minimise adverse…”
Get full text