Search Results - "Donald, David K"

discovery of AZD9164, a novel muscarinic M₃ antagonist by Mete, Antonio, Bowers, Keith, Chevalier, Eric, Donald, David K, Edwards, Helen, Escott, Katherine J, Ford, Rhonan, Grime, Ken, Millichip, Ian, Teobald, Barry, Russell, Vince

“…The optimization of a new series of muscarinic M₃ antagonists is described, leading to the identification of AZD9164 which was progressed into the clinic for…”
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Optimization of Monocarboxylate Transporter 1 Blockers through Analysis and Modulation of Atropisomer Interconversion Properties by Guile, Simon D., Bantick, John R., Cooper, Martin E., Donald, David K., Eyssade, Christine, Ingall, Anthony H., Lewis, Richard J., Martin, Barrie P., Mohammed, Rukhsana T., Potter, Timothy J., Reynolds, Rachel H., St-Gallay, Stephen A., Wright, Andrew D.

“…We have previously described a novel series of potent blockers of the monocarboxylate transporter, MCT1, which show potent immunomodulatory activity in an…”
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Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT-1 by Påhlman, Clara, Qi, Zhongquan, Murray, Clare M, Ferguson, Douglas, Bundick, Robert V, Donald, David K, Ekberg, Henrik

“…We have recently described the immunosuppressive properties of AR-C117977 and AR-C122982, representatives of a group of compounds identified as inhibitors of…”
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Monocarboxylate transporter MCT1 is a target for immunosuppression by Murray, Clare M, Hutchinson, Raymond, Bantick, John R, Belfield, Graham P, Benjamin, Amanda D, Brazma, Diana, Bundick, Robert V, Cook, I David, Craggs, Robert I, Edwards, Susan, Evans, Leslie R, Harrison, Richard, Holness, Elain, Jackson, Andrew P, Jackson, Clive G, Kingston, Lee P, Perry, Matthew W D, Ross, Andrew R J, Rugman, Paul A, Sidhu, Sasvinder S, Sullivan, Michael, Taylor-Fishwick, David A, Walker, P Craig, Whitehead, Yvonne M, Wilkinson, David J, Wright, Andrew, Donald, David K

“…Current immunosuppressive therapies act on T lymphocytes by modulation of cytokine production, modulation of signaling pathways or by inhibition of the enzymes…”
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The design of a novel series of muscarinic receptor antagonists leading to AZD8683, a potential inhaled treatment for COPD by Mete, Antonio, Bowers, Keith, Bull, Richard J., Coope, Helen, Donald, David K., Escott, Katherine J., Ford, Rhonan, Grime, Ken, Mather, Andrew, Ray, Nicholas C., Russell, Vince

“…The design and improvement of a novel series of muscarinic M3 receptor antagonists is described, leading to the identification of AZD8683, which was selected…”
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The specific monocarboxylate transporter-1 (MCT-1) inhibitor, AR-C117977, induces donor-specific suppression, reducing acute and chronic allograft rejection in the rat by EKBERG, Henrik, ZHONGQUAN QI, KERRY, Philip J, WILSON, Elaine, DONALD, David K, PAHLMAN, Clara, VERESS, Bela, BUNDICK, Robert V, CRAGGS, Robert I, HOLNESS, Elain, EDWARDS, Susan, MURRAY, Clare M, FERGUSON, Douglas

“…In a search for immunosuppressive drugs having novel mechanisms, monocarboxylate transporter (MCT-1) inhibitors were identified that markedly inhibited immune…”
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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X7 Receptor Antagonists/Interleukin-1β Inhibitors by Furber, Mark, Alcaraz, Lilian, Bent, Janice E, Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V, Cladingboel, David, Collington, John, Donald, David K, Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C, Laurent, Celine, Lawson, Mandy, Luker, Timothy J, Mortimore, Michael M. P, Pimm, Austen D, Riley, Robert J, Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V, Weaver, Richard, Webborn, Peter, Willis, Paul

“…A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat…”
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Fused mesoionic heterocycles: synthesis of [1,2,3]triazolo[1,5- a]quinoline, [1,2,3]triazolo[1,5- a]quinazoline, [1,2,3]triazolo[1,5- a]quinoxaline and [1,2,3]triazolo[5,1- c]benzotriazine derivatives by Abbott, Phillip A, Bonnert, Roger V, Caffrey, Moya V, Cage, Peter A, Cooke, Andrew J, Donald, David K, Furber, Mark, Hill, Steve, Withnall, Jane

“…General methods are descibed for the synthesis of mesoionic derivatives of [1,2,3]triazolo[1,5- a]quinoline, [1,2,3]triazolo[1,5- a]quinazoline,…”
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The discovery of AZD9164, a novel muscarinic M 3 antagonist by Mete, Antonio, Bowers, Keith, Chevalier, Eric, Donald, David K., Edwards, Helen, Escott, Katherine J., Ford, Rhonan, Grime, Ken, Millichip, Ian, Teobald, Barry, Russell, Vince

“…The optimization of a new series of muscarinic M3 antagonists is described, leading to the identification of AZD9164, which was progressed into the clinic for…”
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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X 7 Receptor Antagonists/Interleukin-1β Inhibitors by Furber, Mark, Alcaraz, Lilian, Bent, Janice E., Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V., Cladingboel, David, Collington, John, Donald, David K., Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C., Laurent, Celine, Lawson, Mandy, Luker, Timothy J., Mortimore, Michael M. P., Pimm, Austen D., Riley, Robert J., Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V., Weaver, Richard, Webborn, Peter, Willis, Paul

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A simple and efficient synthesis of optically pure 4-alkylisoxazolidin-4-ols by Martin, Barrie P., Cooper, Martin E., Donald, David K., Guile, Simon D.

“…The reaction between N-hydroxyphthalimide and optically pure epichlorohydrin followed by addition of methanol represents a straightforward procedure for the…”
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Tourism Dependence in Rural America: Estimates and Effects by English, Donald BK, Marcouiller, David W, Cordell, HKen

“…Recreation and tourism development continue to play an important role in reshaping rural America. Efforts to evaluate the effects of such development are…”
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Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors by Furber, Mark, Alcaraz, Lilian, Bent, Janice E, Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V, Cladingboel, David, Collington, John, Donald, David K, Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C, Laurent, Celine, Lawson, Mandy, Luker, Timothy J, Mortimore, Michael M P, Pimm, Austen D, Riley, Robert J, Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V, Weaver, Richard, Webborn, Peter, Willis, Paul

“…A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat…”
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Use of a modified Elmslie-Trillat procedure to improve abnormal patellar congruence angle by Shelbourne, K D, Porter, D A, Rozzi, W

“…Forty patients underwent 45 modified Elmslie-Trillat realignment procedures (mean followup, 2 years) for refractory patellar instability (34 knees) or painful…”
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FK506 as an agonist to induce inhibition of interleukin 2 production by Bundick, R V, Donald, D K, Eady, R P, Hutchinson, R, Keogh, R W, Schmidt, J A, Wells, E

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Business Statesmanship: A PLAN FOR WAGING THE ECONOMIC WAR by David, Donald K

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3-Chloro-3-cyano-1-(2,4-dimethoxybenzyl)-4-phenylthioazetidin-2-one by K. Donald, David, M. Cambell, Malcolm

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Stress fractures of the medial malleolus by Shelbourne, K D, Fisher, D A, Rettig, A C, McCarroll, J R

“…Six athletes, all engaged in running activities at the time of injury, presented with tenderness over the medial malleolus and ankle effusion. Three patients…”
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A Field-Limited Theory of Cascade Development by Bert, Donald, David K., Collins, Leland F.

“…Recently reported model experiments of Knapp [1] on electroded cascade development provide an excellent set. of data for testing presumptive development models…”
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The effects of electric fields on toner-Carrier adhesion in xerographic development by Donald, D.K., Watson, P.K.

“…Centrifuge measurements and electrostatic charge measurements have shown that the force of adhesion of xerographic toner particles to carrier beads can be…”
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