Search Results - "Donaghy, Paul"

The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis by Donaghy, Paul C, McKeith, Ian G

“…Dementia with Lewy bodies (DLB) is the second most common type of degenerative dementia following Alzheimer's disease (AD). DLB is clinically and…”
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Dementia with Lewy bodies: an update and outlook by Outeiro, Tiago Fleming, Koss, David J, Erskine, Daniel, Walker, Lauren, Kurzawa-Akanbi, Marzena, Burn, David, Donaghy, Paul, Morris, Christopher, Taylor, John-Paul, Thomas, Alan, Attems, Johannes, McKeith, Ian

“…Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and…”
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Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias by King, Eleanor, O’Brien, John Tiernan, Donaghy, Paul, Morris, Christopher, Barnett, Nicola, Olsen, Kirsty, Martin-Ruiz, Carmen, Taylor, John-Paul, Thomas, Alan J

“…ObjectivesThere is growing evidence for the role of systemic inflammation in Alzheimer’s disease (AD) and other neurodegenerative diseases; however the…”
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Inflammation in dementia with Lewy bodies by Amin, Jay, Erskine, Daniel, Donaghy, Paul C., Surendranathan, Ajenthan, Swann, Peter, Kunicki, Amy P., Boche, Delphine, Holmes, Clive, McKeith, Ian G., O'Brien, John T., Teeling, Jessica L., Thomas, Alan J.

“…Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia, behind Alzheimer's disease (AD). The profile of inflammation in…”
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Do Alzheimer's and Lewy body disease have discrete pathological signatures of gait? by Mc Ardle, Ríona, Galna, Brook, Donaghy, Paul, Thomas, Alan, Rochester, Lynn

“…We aimed to refine the hypothesis that dementia has a unique signature of gait impairment reflective of underlying pathology by considering two dementia…”
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Cholinergic white matter pathways in dementia with Lewy bodies and Alzheimer's disease by Schumacher, Julia, Ray, Nicola J, Hamilton, Calum A, Donaghy, Paul C, Firbank, Michael, Roberts, Gemma, Allan, Louise, Durcan, Rory, Barnett, Nicola, O'Brien, John T, Taylor, John-Paul, Thomas, Alan J

“…Patients who have dementia with Lewy bodies and Alzheimer's disease show early degeneration of the cholinergic nucleus basalis of Meynert. However, how white…”
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The Impact of Environment on Gait Assessment: Considerations from Real-World Gait Analysis in Dementia Subtypes by Mc Ardle, Ríona, Del Din, Silvia, Donaghy, Paul, Galna, Brook, Thomas, Alan J, Rochester, Lynn

“…Laboratory-based gait assessments are indicative of clinical outcomes (e.g., disease identification). Real-world gait may be more sensitive to clinical…”
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Free water imaging of the cholinergic system in dementia with Lewy bodies and Alzheimer's disease by Schumacher, Julia, Ray, Nicola J, Hamilton, Calum A, Bergamino, Maurizio, Donaghy, Paul C, Firbank, Michael, Watson, Rosie, Roberts, Gemma, Allan, Louise, Barnett, Nicola, O'Brien, John T, Thomas, Alan J, Taylor, John-Paul

“…Degeneration of cortical cholinergic projections from the nucleus basalis of Meynert (NBM) is characteristic of dementia with Lewy bodies (DLB) and Alzheimer's…”
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Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies by Donaghy, Paul C, Taylor, John-Paul, O'Brien, John T, Barnett, Nicola, Olsen, Kirsty, Colloby, Sean J, Lloyd, Jim, Petrides, George, McKeith, Ian G, Thomas, Alan J

“…The accurate clinical characterisation of mild cognitive impairment (MCI) is becoming increasingly important. The aim of this study was to compare the…”
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Mild cognitive impairment with Lewy bodies: neuropsychiatric supportive symptoms and cognitive profile by Donaghy, Paul C, Ciafone, Joanna, Durcan, Rory, Hamilton, Calum A, Barker, Sally, Lloyd, Jim, Firbank, Michael, Allan, Louise M, O'Brien, John T, Taylor, John-Paul, Thomas, Alan J

“…Recently published diagnostic criteria for mild cognitive impairment with Lewy bodies (MCI-LB) include five neuropsychiatric supportive features (non-visual…”
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Associations between multimorbidity and neuropathology in dementia: consideration of functional cognitive disorders, psychiatric illness and dementia mimics by Hamilton, Calum A., Matthews, Fiona E., Attems, Johannes, Donaghy, Paul C., Erskine, Daniel, Taylor, John-Paul, Thomas, Alan J.

“…Multimorbidity, the presence of two or more health conditions, has been identified as a possible risk factor for clinical dementia. It is unclear whether this…”
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Amyloid PET Imaging in Lewy Body Disorders by Donaghy, Paul, M.Res, Thomas, Alan J., Ph.D, O'Brien, John T., D.M

“…Lewy body (LB) disorders, including Parkinson disease (PD), Parkinson disease dementia (PDD), and dementia with Lewy bodies (DLB), are the second most common…”
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Accuracy of Cardiac Innervation Scintigraphy for Mild Cognitive Impairment With Lewy Bodies by Roberts, Gemma, Durcan, Rory, Donaghy, Paul C., Lawley, Sarah, Ciafone, Joanna, Hamilton, Calum A., Colloby, Sean J., Firbank, Michael J., Allan, Louise, Barnett, Nicola, Barker, Sally, Howe, Kim, Ali, Tamir, Petrides, George S., Lloyd, Jim, Taylor, John-Paul, O'Brien, John, Thomas, Alan J.

“…To provide evidence that cardiac I-123-metaiodobenzylguanidine sympathetic innervation imaging (MIBG) scintigraphy differentiates probable mild cognitive…”
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Accuracy of dopaminergic imaging as a biomarker for mild cognitive impairment with Lewy bodies by Roberts, Gemma, Donaghy, Paul C., Lloyd, Jim, Durcan, Rory, Petrides, George, Colloby, Sean J., Lawley, Sarah, Ciafone, Joanna, Hamilton, Calum A., Firbank, Michael, Allan, Louise, Barnett, Nicola, Barker, Sally, Olsen, Kirsty, Howe, Kim, Ali, Tamir, Taylor, John-Paul, O'Brien, John, Thomas, Alan J.

“…Dopaminergic imaging is an established biomarker for dementia with Lewy bodies, but its diagnostic accuracy at the mild cognitive impairment (MCI) stage…”
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Clinical and imaging correlates of amyloid deposition in dementia with Lewy bodies by Donaghy, Paul C., Firbank, Michael J, Thomas, Alan J., Lloyd, Jim, Petrides, George, Barnett, Nicola, Olsen, Kirsty, O'Brien, John T.

“…ABSTRACT Background: Amyloid deposition is common in dementia with Lewy bodies, but its pathophysiological significance is unclear. Objective: The objective of…”
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EEG Functional Connectivity Differences Predict Future Conversion to Dementia in Mild Cognitive Impairment With Lewy Body or Alzheimer Disease by Hasoon, Jahfer, Hamilton, Calum A., Schumacher, Julia, Colloby, Sean, Donaghy, Paul C., Thomas, Alan J., Taylor, John‐Paul

“…ABSTRACT Background Predicting which individuals may convert to dementia from mild cognitive impairment (MCI) remains difficult in clinical practice…”
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Clinical symptoms in mild cognitive impairment with Lewy bodies: Frequency, time of onset, and discriminant ability by Donaghy, Paul C., Hamilton, Calum, Durcan, Rory, Lawley, Sarah, Barker, Sally, Ciafone, Joanna, Barnett, Nicola, Olsen, Kirsty, Firbank, Michael, Roberts, Gemma, Lloyd, Jim, Allan, Louise M., Saha, Ranjan, McKeith, Ian G., O'Brien, John T., Taylor, John‐Paul, Thomas, Alan J.

“…Background and purpose Mild cognitive impairment with Lewy bodies (MCI‐LB) is associated with a range of cognitive, motor, neuropsychiatric, sleep, autonomic,…”
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EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer's disease by Schumacher, Julia, Thomas, Alan J, Peraza, Luis R, Firbank, Michael, Cromarty, Ruth, Hamilton, Calum A, Donaghy, Paul C, O'Brien, John T, Taylor, John-Paul

“…Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), is characterised by marked deficits within the…”
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Functional connectivity in Lewy body disease with visual hallucinations by Firbank, Michael J., Collerton, Daniel, Morgan, Katrina daSilva, Schumacher, Julia, Donaghy, Paul C., O'Brien, John T., Thomas, Alan, Taylor, John‐Paul

“…Background and purpose Visual hallucinations are a common, potentially distressing experience of people with Lewy body disease (LBD). The underlying brain…”
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Progression to Dementia in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease by Hamilton, Calum A., Matthews, Fiona E., Donaghy, Paul C., Taylor, John-Paul, O'Brien, John T., Barnett, Nicola, Olsen, Kirsty, Durcan, Rory, Roberts, Gemma, Ciafone, Joanna, Barker, Sally A.H., Firbank, Michael, McKeith, Ian G., Thomas, Alan J.

“…To determine whether mild cognitive impairment with Lewy bodies or mild cognitive impairment with Alzheimer disease differ in their rates of clinical…”
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