Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis

OBJECTIVE: To compare the prevalence of cardiovascular diseases and their risk factors between patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) and control subjects. METHODS: Data for patients continuously enrolled in an integrated outcomes database...

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Published in:	Journal of rheumatology Vol. 33; no. 11; pp. 2167 - 2172
Main Authors:	Chenglong Han, Don W Robinson, Jr, Monica V Hackett, L Clark Paramore, Kathy H Fraeman, Mohan V Bala
Format:	Journal Article
Language:	English
Published:	Toronto, ON The Journal of Rheumatology 01-11-2006 Journal of Rheumatology Publishing
Subjects:	Arthritis, Psoriatic - epidemiology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - epidemiology Cardiovascular Diseases - immunology Comorbidity Cross-Sectional Studies Databases as Topic Dermatology Diabetes Mellitus, Type 2 - epidemiology Diseases of the osteoarticular system Female Humans Hyperlipidemias - epidemiology Hypertension - epidemiology Inflammatory joint diseases Male Medical sciences Middle Aged Prevalence Psoriasis. Parapsoriasis. Lichen Spondylitis, Ankylosing - epidemiology United States - epidemiology United States Human Immunopathology Skin disease Psoriasis Diseases of the osteoarticular system Autoimmune disease Cardiovascular disease Inflammatory joint disease Psoriatic arthritis Spondylarthropathy Vascular disease Rheumatoid factor Chronic Rheumatoid arthritis Atherosclerosis Risk factor Ankylosing spondylitis
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Summary:	OBJECTIVE: To compare the prevalence of cardiovascular diseases and their risk factors between patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) and control subjects. METHODS: Data for patients continuously enrolled in an integrated outcomes database between January 1, 2001, and December 31, 2002, with International Classification of Diseases, 9th Revision codes of 714.x (RA), 696.0 (PsA), or 720.0 (AS) were evaluated in this cross-sectional comparative study. Control groups were established for each patient group (1:4 ratio) by matching on the basis of age, sex, geographic region, and length of time in plan. Age- and sex-adjusted prevalence of cardiovascular comorbidities and risk factors were calculated; the prevalence ratio of the comorbidities and risk factors for the patient groups compared with the control population were estimated. Use of selected cardiovascular medications was also compared between patient and control groups. RESULTS: The RA, PsA, and AS cohorts comprised 28,208, 3066, and 1843 patients, respectively. The prevalence ratio of ischemic heart disease (1.5, 1.3, 1.2), atherosclerosis (1.9, 1.4, 1.5), peripheral vascular disease (2.4, 1.6, 1.6), congestive heart failure (2.0, 1.5, 1.8), cerebrovascular disease (1.6, 1.3, 1.7), type II diabetes (1.4, 1.5, 1.2), hyperlipidemia (1.2, 1.2, 1.2), and hypertension (1.3, 1.3, 1.3) were higher in patients than controls. For RA, PsA, and AS, use of angiotensin-converting enzyme inhibitors, calcium channel blockers, diuretics, nitrates/vasodilators, anticoagulants, and antihyperlipidemia agents was significantly higher in patients than controls. CONCLUSION: Cardiovascular diseases and their risk factors were more common in patients with RA, PsA, and AS than in matched controls.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0315-162X 1499-2752