Search Results - "Dompe, Nicholas"

A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC by Dompe, Nicholas, Klijn, Christiaan, Watson, Sara A, Leng, Katherine, Port, Jenna, Cuellar, Trinna, Watanabe, Colin, Haley, Benjamin, Neve, Richard, Evangelista, Marie, Stokoe, David

“…Mutant KRAS represents one of the most frequently observed oncogenes in NSCLC, yet no therapies are approved for tumors that express activated KRAS variants…”
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A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac by Thibault, Stephen T, Singer, Matthew A, Miyazaki, Wesley Y, Milash, Brett, Dompe, Nicholas A, Singh, Carol M, Buchholz, Ross, Demsky, Madelyn, Fawcett, Robert, Francis-Lang, Helen L, Ryner, Lisa, Cheung, Lai Man, Chong, Angela, Erickson, Cathy, Fisher, William W, Greer, Kimberly, Hartouni, Stephanie R, Howie, Elizabeth, Jakkula, Lakshmi, Joo, Daniel, Killpack, Keith, Laufer, Alex, Mazzotta, Julie, Smith, Ronald D, Stevens, Lynn M, Stuber, Christiana, Tan, Lory R, Ventura, Richard, Woo, Alesa, Zakrajsek, Irena, Zhao, Lora, Chen, Feng, Swimmer, Candace, Kopczynski, Casey, Duyk, Geoffrey, Winberg, Margaret L, Margolis, Jonathan

“…With the availability of complete genome sequence for Drosophila melanogaster, one of the next strategic goals for fly researchers is a complete gene knockout…”
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Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome by Friedman, Lori, Deal, Jennifer E, Howie, Elizabeth, Tan, Lory R, Edgar, Kyle A, Plowman, Gregory D, Marcinko, Marie, Winter, Christopher G, Milash, Brett, Winner, Millicent A, Cook, Kevin R, Parks, Annette L, Belvin, Marcia, Fawcett, Robert, Andrade, Rachel S, Kopczynski, Casey, Killpack, Keith, Duyk, Geoffrey, Grant, Deanna, Shaw, Kenneth J, Huppert, Kari, Miyazaki, Wesley Y, Margolis, Jonathan, Tabios, Mariano, Thao, Doua, Vysotskaia, Valentina, Kaufman, Thomas C, Zhao, Lora, Francis-Lang, Helen L, Robertson, Stephanie, Dompe, Nicholas A, Curtis, Daniel, Whittaker, Kellie, Deal-Herr, Megan E, Norton, Amanda, Bogart, Kevin P, Singer, Matthew A

“…In fruit fly research, chromosomal deletions are indispensable tools for mapping mutations, characterizing alleles and identifying interacting loci. Most…”
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whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis by Dompe, Nicholas, Rivers, Celina Sanchez, Li, Li, Cordes, Shaun, Schwickart, Martin, Punnoose, Elizabeth A, Amler, Lukas, Seshagiri, Somasekar, Tang, Jerry, Modrusan, Zora, Davis, David P

“…Deregulation of apoptosis is a common occurrence in cancer, for which emerging oncology therapeutic agents designed to engage this pathway are undergoing…”
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Abstract 4410: Predictive model of palbociclib response reveals indications in which CDK4/6 inhibitor can be a potential combination partner by Hafner, Marc, Dompe, Nicholas, Zhou, Wei, Lin, Eva, Durrbaum, Milena, Daemen, Anneleen, Junttila, Melissa R., Metcalfe, Ciara, Merrick, Karl

“…CDK4/6 inhibitors are a promising class of targeted therapies, with three molecules (palbociclib, ribociclib, and abemaciclib) approved for advanced…”
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Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma by Bronner, Sarah M., Merrick, Karl A., Murray, Jeremy, Salphati, Laurent, Moffat, John G., Pang, Jodie, Sneeringer, Christopher J., Dompe, Nicholas, Cyr, Patrick, Purkey, Hans, Boenig, Gladys de Leon, Li, Jun, Kolesnikov, Aleksandr, Larouche-Gauthier, Robin, Lai, Kwong Wah, Shen, Xiaoli, Aubert-Nicol, Samuel, Chen, Yi-Chen, Cheong, Jonathan, Crawford, James J., Hafner, Marc, Haghshenas, Pouyan, Jakalian, Araz, Leclerc, Jean-Philippe, Lim, Ngiap-Kie, O'Brien, Tom, Plise, Emile G., Shalan, Hadil, Sturino, Claudio, Wai, John, Xiao, Yang, Yin, Jianping, Zhao, Liang, Gould, Stephen, Olivero, Alan, Heffron, Timothy P.

“…[Display omitted] CDK4 and CDK6 are kinases with similar sequences that regulate cell cycle progression and are validated targets in the treatment of cancer…”
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Abstract B22: Potential combinatorial strategies to overcome drug resistance in BRAF-mutant melanoma by Dompe, Nicholas A., Lin, Eva, Peng, Jing, Chan, Grace, Tien, Janet, Merchant, Mark, Bourgon, Richard, Settleman, Jeffrey, Wilson, Timothy, Neve, Richard M.

“…RAF and MEK inhibitors are used to target malignant melanomas harbouring BRAF V600E mutations, but resistance to these therapies remains a significant…”
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A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis by Dompe, Nicholas, Rivers, Celina Sanchez, Li Li, Cordes, Shaun, Schwickart, Martin, Punnoose, Elizabeth A., Amler, Lukas, Seshagiri, Somasekar, Tang, Jerry, Modrusan, Zora, Davis, David P.

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Amphiregulin and PTEN evoke a multimodal mechanism of acquired resistance to PI3K inhibition by Edgar, Kyle A, Crocker, Lisa, Cheng, Eric, Wagle, Marie-Claire, Wongchenko, Matthew, Yan, Yibing, Wilson, Timothy R, Dompe, Nicholas, Neve, Richard M, Belvin, Marcia, Sampath, Deepak, Friedman, Lori S, Wallin, Jeffrey J

“…Phosphoinositide-3 kinase (PI3K) signaling pathway alterations occur broadly in cancer and PI3K is a promising therapeutic target. Here, we investigated…”
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