Search Results - "Dominy, Beryl W."

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings by Lipinski, Christopher A., Lombardo, Franco, Dominy, Beryl W., Feeney, Paul J.

“…Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described. In the discovery setting…”
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings by Lipinski, Christopher A., Lombardo, Franco, Dominy, Beryl W., Feeney, Paul J.

“…Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described. In the discovery setting…”
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings by Lipinski, Christopher A, Lombardo, Franco, Dominy, Beryl W, Feeney, Paul J

“…Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described. In the discovery setting…”
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Synthesis, absolute configuration and conformation of the aldose reductase inhibitor sorbinil by Sarges, Reinhard, Bordner, Jon, Dominy, Beryl W, Peterson, Michael J, Whipple, Earl B

“…The aldose reductase inhibitor 2,3-dihydro-6-fluorospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5 '-dione was resolved into its enantiomers. Sorbinil, the S…”
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1 by Lipinski, Christopher A, Lombardo, Franco, Dominy, Beryl W, Feeney, Paul J

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trans-3-benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor by REITER, L. A, KOCH, K, DIBRINO, J. N, DOMINY, B. W, FARRELL, C. A, HINGORANI, G. P, MARTINELLI, G. J, RAMCHANDANI, M, WRIGHT, K. F, PISCOPIO, A. D, SHOWELL, H. J, ALPERT, R, BIGGERS, M. S, CHAMBERS, R. J, CONKLYN, M. J, COOPER, K, CORTINA, S. R

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Neuroleptic activity of chiral trans-hexahydro-.gamma.-carbolines by Sarges, Reinhard, Howard, Harry R, Donahue, Kathy M, Welch, Williard M, Dominy, Beryl W, Weissman, Albert, Koe, B. Kenneth, Bordner, Jon

“…A series of trans-8-fluoro-5-(4-fluorophenyl)-2,3,4,4a,5, 9b-hexahydro-1H-pyrido[4,3-b]indoles with various N-2 substituents has been prepared and tested for…”
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Synthesis and antibacterial activity of 1-hydroxy-1-methyl-1,3-dihydrofuro[3,4-b]quinoxaline 4,9-dioxide and related compounds by Dirlam, John P, Czuba, Leonard J, Dominy, Beryl W, James, Richard B, Pezzullo, Richard M, Presslitz, Joseph E, Windisch, Wendell W

“…A Free-Wilson analysis of the antibacterial activity found in a variety of quinoxaline 1,4-dioxides prepared and tested in these laboratories unexpectedly…”
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Direct observation by X‐ray analysis of the tetrahedral “intermediate” of aspartic proteinases by Veerapandian, B., Cooper, Jon B., Šali, Andrej, Blundell, Tom L., Rosati, Robert L., Dominy, Beryl W., Damon, David B., Hoover, Dennis J.

“…We report the X‐ray analysis at 2.0 Å resolution for crystals of the aspartic proteinase endothiapepsin (EC 3.4.23.6) complexed with a potent…”
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trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor by Reiter, L A, Koch, K, Piscopio, A D, Showell, H J, Alpert, R, Biggers, M S, Chambers, R J, Conklyn, M J, Cooper, K, Cortina, S R, Dibrino, J N, Dominy, B W, Farrell, C A, Hingorani, G P, Martinelli, G J, Ramchandani, M, Wright, K F

“…The SAR of a series of 2-(7-chromanyl)benzoic acids has been investigated with the aim of identifying potent and selective LTB4 receptor antagonists that…”
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trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B 4 (LTB 4) receptor by Reiter, Lawrence A., Koch, Kevin, Piscopio, Anthony D., Showell, Henry J., Alpert, Robbin, Biggers, Michael S., Chambers, Robert J., Conklyn, Maryrose J., Cooper, Kelvin, Cortina, Santo R., Dibrino, Joseph N., Dominy, Beryl W., Farrell, Cathy A., Hingorani, Gary P., Martinelli, Gary J., Ramchandani, Mukesh, Wright, Kathyrn F.

“…The SAR of a series of 2-(7-chromanyl)benzoic acids has been investigated with the aim of identifying potent and selective LTB 4 receptor antagonists that…”
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Computer graphics modelling of human renin: Specificity, catalytic activity and intron-exon junctions by Sibanda, Bancinyane L., Blundell, Tom, Hobart, Peter M., Fogliano, M., Bindra, Jasjit S., Dominy, Beryl W., Chirgwin, John M.

“…A model has been constructed using computer graphics for human renin based on the sequence derived from that of the gene and the 3-dimensional structure…”
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Computer graphics modelling of human renin by Sibanda, Bancinyane L., Blundell, Tom, Hobart, Peter M., Fogliano, M., Bindra, Jasjit S., Dominy, Beryl W., Chirgwin, John M.

“…A model has been constructed using computer graphics for human renin based on the sequence derived from that of the gene and the 3‐dimensional structure…”
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Dopamine receptor blockade by imidoline and its proposed active conformation by Koe, B K, Koch, S W, Dominy, B W

“…Imidoline, 1-[2-(N,N-dimethylamino)ethyl]-3-m-chlorophenyl-2-imidazolidinone, has been found to be as potent as chlorpromazine in increasing striatal DOPA…”
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3-Benzylidene-2,5-diketopiperazine by Dominy, Beryl William, Lawton, Richard G

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