Urinary excretion kinetics of [177Lu]Lu-PSMA-617

Urinary excretion kinetics of [177Lu]Lu-PSMA-617

Introduction For the implementation of suitable radiation safety measures in [ 177 Lu]Lu-PSMA-617 therapy, additional insight into excretion kinetics is important. This study evaluates this kinetics in prostate cancer patients via direct urine measurements. Methods Both the short-term (up to 24 h, n...

Full description

Saved in:
Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging Vol. 50; no. 12; pp. 3572 - 3575
Main Authors: de Bakker, Maarten, Dominicus, Noa, Meeuwis, Antoi, Janssen, Marcel, Konijnenberg, Mark W., Nagarajah, James, Peters, Steffie M. B.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-10-2023
Springer Nature B.V
Subjects:
Cardiology
Contamination
Excretion
Imaging
Kinetics
Lutetium isotopes
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Orthopedics
Prostate cancer
Radiation
Radiation measurement
Radiology
Safety measures
Scintillation counters
Short Communication
Urine
Waste management
Therapy
PSMA
Excretion kinetics
Radiation safety
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction For the implementation of suitable radiation safety measures in [ 177 Lu]Lu-PSMA-617 therapy, additional insight into excretion kinetics is important. This study evaluates this kinetics in prostate cancer patients via direct urine measurements. Methods Both the short-term (up to 24 h, n  = 28 cycles) and long-term kinetics (up to 7 weeks, n  = 35 samples) were evaluated by collection of urine samples. Samples were measured on a scintillation counter to determine excretion kinetics. Results The mean excretion half-time during the first 20 h was 4.9 h. Kinetics was significantly different for patients with kidney function below or above eGFR 65 ml/min. Calculated skin equivalent dose in case of urinary contamination was between 50 and 145 mSv when it was caused between 0 and 8 h p.i.. Measurable amounts of 177 Lu were found in urine samples up to 18 days p.i.. Conclusion Excretion kinetics of [ 177 Lu]Lu-PSMA-617 is especially relevant during the first 24 h, when accurate radiation safety measures are important to prevent skin contamination. Measures for accurate waste management are relevant up to 18 days.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-023-06328-8