Search Results - "Dominianni, Samuel J"

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist by Xu, Yanping, Mayhugh, Daniel, Saeed, Ashraf, Wang, Xiaodong, Thompson, Richard C, Dominianni, Samuel J, Kauffman, Raymond F, Singh, Jaipal, Bean, James S, Bensch, William R, Barr, Robert J, Osborne, John, Montrose-Rafizadeh, Chahrzad, Zink, Richard W, Yumibe, Nathan P, Huang, Naijia, Luffer-Atlas, Debra, Rungta, Deepa, Maise, Dale E, Mantlo, Nathan B

“…A new series of hPPARα agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a…”
Get full text

Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids:  A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/γ Agonists by Xu, Yanping, Rito, Christopher J, Etgen, Garret J, Ardecky, Robert J, Bean, James S, Bensch, William R, Bosley, Jacob R, Broderick, Carol L, Brooks, Dawn A, Dominianni, Samuel J, Hahn, Patric J, Liu, Sha, Mais, Dale E, Montrose-Rafizadeh, Chahrzad, Ogilvie, Kathy M, Oldham, Brian A, Peters, Mary, Rungta, Deepa K, Shuker, Anthony J, Stephenson, Gregory A, Tripp, Allie E, Wilson, Sarah B, Winneroski, Leonard L, Zink, Richard, Kauffman, Raymond F, McCarthy, James R

“…The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) α/γ agonist…”
Get full text

Design and Synthesis of 2-Methyl-2-{4-[2-(5-methyl-2-aryloxazol- 4-yl)ethoxy]phenoxy}propionic Acids:  A New Class of Dual PPARα/γ Agonists by Brooks, Dawn A, Etgen, Garret J, Rito, Christopher J, Shuker, Anthony J, Dominianni, Samuel J, Warshawsky, Alan M, Ardecky, Robert, Paterniti, James R, Tyhonas, John, Karanewsky, Donald S, Kauffman, Raymond F, Broderick, Carol L, Oldham, Brian A, Montrose-Rafizadeh, Chahzrad, Winneroski, Leonard L, Faul, Margaret M, McCarthy, James R

“…Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPARγ- and PPARα-selective compounds, exhibits potent…”
Get full text

Oral hypoglycemic agents. Discovery and structure-activity relationships of phenacylimidazolium halides by Dominianni, Samuel J, Yen, Terence T

“…Blood glucose levels in viable, yellow, obese, diabetic mice are reduced following oral administration of phenacylimidazolium halides. Compounds 2 and 3…”
Get full text

Synthesis of 2-Phenyloxazole Derivatives Containing Amino Acids as Insulin Sensitivity Enhancers for Treatment of Type II Diabetes by M. Faul, Margaret, L. Winneroski, Leonard, S. York, Jeremy, R. Reinhard, Matt, C. Hoying, Richard, H. Gritton, William, J. Dominianni, Samuel

Get full text

Derivatives of 7-oxabicyclo[2.2.1]heptane-exo-cis-2,3-dicarboxylic acid by Dominianni, Samuel J, Young, Ronald L

Get full text

Azomethine Chemistry. IV. Chemistry of Fused Thiazolidines1,2 by Hiskey, Richard G, Dominianni, Samuel J

Get full text

Lithium aluminum hydride reduction of bridged bicyclic nitroso chloride dimers by Dominianni, Samuel J, Demarco, P. V

Get full text

Central nervous system active butyrophenones. 1. Unsaturated analogs of .gamma.-aminobutyrophenones by Dominianni, Samuel J, Pioch, Richard P, Young, Ronald L

Get full text

Central nervous system active butyrophenones. 2. Methyl-branched .gamma.-aminobutyrophenones by Dominianni, Samuel J, Pioch, Richard P, Young, Ronald L, Stimart, Patrick J

Get full text

Design and synthesis of 2-methyl-2-{4-[2-(5-methyl-2-aryloxazol-4-yl)ethoxy]phenoxy}propionic acids : A new class of dual PPARrα/γ agonists by BROOKS, Dawn A, ETGEN, Garret J, KAUFFMAN, Raymond F, BRODERICK, Carol L, OLDHAM, Brian A, MONTROSE-RAFIZADEH, Chahzrad, WINNEROSKI, Leonard L, FAUL, Margaret M, MCCARTHY, James R, RITO, Christopher J, SHUKER, Anthony J, DOMINIANNI, Samuel J, WARSHAWSKY, Alan M, ARDECKY, Robert, PATERNITI, James R, TYHONAS, John, KARANEWSKY, Donald S

Get full text

Competitive particle concentration fluorescence immunoassays for measuring anti-diabetic drug levels in mouse plasma by Bright, Stuart W., Tinsley, Frank C., Dominianni, Samuel J., Schmiegel, Klaus K., Fitch, Lora L., Gold, Gerald

“…Two competitive particle concentration fluorescence immunoassays were developed to measure blood levels of analogs of anti-diabetic drugs being tested in…”
Get full text

Monoclonal antibodies as surrogate receptors in a high throughput screen for compounds that enhance insulin sensitivity by Bright, Stuart W., Gold, Gerald, Sage, Scott W., Sportsman, J.Richard, Tinsley, Frank C., Dominianni, Samuel J., Schmiegel, Klaus K., Kellam, Marcia L., Fitch, Lora L., Yen, Terence T.

“…Monoclonal antibodies (MoAbs) were made to a known insulin sensitivity enhancer (ISE) compound, CS-045. The MoAbs were characterized with respect to binding…”
Get full text

Metabolic effects of proglycosyn by Yamanouchi, K, Stephens, T W, Chikada, K, Dominianni, S J, Behforouz, H, Scislowski, P, DePaoli-Roach, A, Allmann, D W, Harris, R A

“…Proglycosyn, a phenylacyl imidazolium compound that lowers blood glucose levels, was demonstrated previously to promote hepatic glycogen synthesis, stabilize…”
Get more information

Azomethine Chemistry. IV. Chemistry of Fused Thiazolidines 1,2 by Hiskey, Richard G., Dominianni, Samuel J.

Get full text

Some derivatives of 7-oxabicyclo(2.2.1)heptane-exo-cis-2,3-dicarboxylic acid by Dominanni, S J, Young, R L

Get full text