Search Results - "Dominguez, Ana Lucía"

CRISPR-mediated TGFBR2 knockout renders human ovarian cancer tumor-infiltrating lymphocytes resistant to TGF-β signaling by Fix, Samantha M, Forget, Marie-Andrée, Sakellariou-Thompson, Donastas, Wang, Yunfei, Griffiths, Tamara M, Lee, Minjung, Haymaker, Cara L, Dominguez, Ana Lucía, Basar, Rafet, Reyes, Christopher, Kumar, Sanjay, Meyer, Larissa A, Hwu, Patrick, Bernatchez, Chantale, Jazaeri, Amir A

“…BackgroundThe correlation between elevated T-cell infiltration and improved survival of ovarian cancer (OvCa) patients suggests that endogenous…”
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172 Overcoming immunosuppressive TGF-β signaling in human ovarian cancer-derived tumor infiltrating lymphocytes via non-viral CRISPR engineering by Fix, Samantha, Forget, Marie-Andrée, Sakellariou-Thompson, Donastas, Wang, Yunfei, Dominguez, Ana Lucía, Basar, Rafet, Reyes, Christopher, Kumar, Sanjay, Meyer, Larissa, Hwu, Patrick, Bernatchez, Chantale, Jazaeri, Amir

“…BackgroundOur ongoing clinical trial for the treatment of melanoma with TGF-β-resistant tumor-infiltrating lymphocytes (TIL) [TGF-β dominant negative receptor…”
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Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity by Punt, Simone, Malu, Shruti, McKenzie, Jodi A., Manrique, Soraya Zorro, Doorduijn, Elien M., Mbofung, Rina M., Williams, Leila, Silverman, Deborah A., Ashkin, Emily L., Dominguez, Ana Lucía, Wang, Zhe, Chen, Jie Qing, Maiti, Sourindra N., Tieu, Trang N., Liu, Chengwen, Xu, Chunyu, Forget, Marie-Andrée, Haymaker, Cara, Khalili, Jahan S., Satani, Nikunj, Muller, Florian, Cooper, Laurence J. N., Overwijk, Willem W., Amaria, Rodabe N., Bernatchez, Chantale, Heffernan, Timothy P., Peng, Weiyi, Roszik, Jason, Hwu, Patrick

“…Although immunotherapy has achieved impressive durable clinical responses, many cancers respond only temporarily or not at all to immunotherapy. To find novel,…”
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Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth by Manrique, Soraya Zorro, Correa, Maria Adelaida Duque, Hoelzinger, Dominique B, Dominguez, Ana Lucia, Mirza, Noweeda, Lin, Hsi-Hsien, Stein-Streilein, Joan, Gordon, Siamon, Lustgarten, Joseph

“…Regulatory T cells (T reg cells) are characterized by the expression of the forkhead lineage-specific transcription factor Foxp3, and their main function is to…”
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Flagellin Fusion Proteins as Adjuvants or Vaccines Induce Specific Immune Responses by Cuadros, Camilo, Lopez-Hernandez, Francisco J, Dominguez, Ana Lucia, McClelland, Michael, Lustgarten, Joseph

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Aging affect the anti-tumor potential of dendritic cell vaccination, but it can be overcome by co-stimulation with anti-OX40 or anti-4-1BB by Sharma, Sanjay, Lucia Dominguez, Ana, Lustgarten, Joseph

“…It has been well established that there is a decline in immune function with age resulting in a diminished capacity to respond to infections or tumors…”
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The CD8+ T cell repertoire against Her‐2/neu antigens in neu transgenic mice is of low avidity with antitumor activity by Lustgarten, Joseph, Dominguez, Ana Lucia, Cuadros, Camilo

“…The majority of tumor‐associated antigens are aberrantly expressed or overexpressed normal gene products. Therefore, mechanisms responsible for self tolerance…”
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Estudios sobre las condiciones laborales del Trabajo Social en diferentes países de América Latina entre los años 2000-2021. Aportes al debate profesional by Carlos Lasso Urbano, Silvia Rocío Moncayo Quiñonez, Ana Lucía Coral Domínguez

“…Objetivo. Identificar las diversas investigaciones y producciones académicas sobre las condiciones laborales de los/as trabajadores/as sociales que se han…”
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Condiciones laborales de profesionales de Trabajo Social egresados de la Universidad Mariana en Pasto-Colombia. Entre la precarización laboral y el impacto en el ejercicio profesional by Lasso-Urbano, Carlos, Moncayo-Quiñonez, Silvia Berenice Rocío, Coral-Domínguez, Ana Lucía

“…El artículo da a conocer las condiciones laborales de trabajadores sociales, egresados de la Universidad Mariana de Pasto, Colombia, entre los años 2015 y 2020…”
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High Accumulation of T Regulatory Cells Prevents the Activation of Immune Responses in Aged Animals by Sharma, Sanjay, Dominguez, Ana Lucia, Lustgarten, Joseph

“…In our previous in vivo study we demonstrated that young BALB/c mice effectively rejected the BM-185 tumor cells expressing enhanced GFP (EGFP) as a surrogate…”
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Targeting the tumor microenvironment with anti-neu/anti-CD40 conjugated nanoparticles for the induction of antitumor immune responses by Dominguez, Ana Lucia, Lustgarten, Joseph

“…Abstract Clinical and preclinical data indicate that immunotherapeutic interventions could induce immune responses capable of controlling or retard the tumor…”
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Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid T-cell sensitization and rejection of progressive tumor challenges by Hoelzinger, Dominique B, Dominguez, Ana Lucia, Cohen, Peter A, Gendler, Sandra J

“…The tolerogenic cytokine IL9 promotes T regulatory cell function and allergic airway inflammation, but it has not been extensively studied in cancer. In this…”
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Implications of Aging and Self-Tolerance on the Generation of Immune and Antitumor Immune Responses by DOMINGUEZ, Ana Lucia, LUSTGARTEN, Joseph

“…Cancer statistics show a disproportionately higher burden of tumors in the old. Most of the studies evaluating vaccination strategies have not taken into…”
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Blockade of CCL1 inhibits T regulatory cell suppressive function enhancing tumor immunity without affecting T effector responses by Hoelzinger, Dominique B, Smith, Shannon E, Mirza, Noweeda, Dominguez, Ana Lucia, Manrique, Soraya Zorro, Lustgarten, Joseph

“…Intratumoral accumulation of T regulatory cells (Tregs) creates an immunosuppressive environment that reduces the efficacy of antitumor immunotherapy. The…”
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Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age‐related alterations by Mirza, Noweeda, Pollock, Kevin, Hoelzinger, Dominique B., Dominguez, Ana Lucia, Lustgarten, Joseph

“…Summary It is well established that immune responses are diminished in the old. However, we still do not have a clear understanding of what dictates the…”
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Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses by Smith, Shannon E., Hoelzinger, Dominique B., Dominguez, Ana Lucia, Van Snick, Jacques, Lustgarten, Joseph

“…Previous studies from our laboratory indicate that intratumoral (i.t.) injections of CpG-ODN are the most effective adjuvant strategy to induce an antitumor…”
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Inhibition of adaptive immunity by IL-9 can be disrupted to achieve rapid T cell sensitization and rejection of progressive tumor challenges by Hoelzinger, Dominique B., Dominguez, Ana Lucia, Cohen, Peter A., Gendler, Sandra J.

“…The tolerogenic cytokine IL-9 promotes T regulatory cell function and allergic airway inflammation, but it has not been extensively studied in cancer. In this…”
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Abstract 3640: IL-9 is involved in the establishment of a tolerogenic milieu that prevents anti-tumor immunity by Hoelzinger, Dominique B., Dominguez, Ana Lucia, Cohen, Peter A., Gendker, Sandra J.

“…Abstract IL-9 is a Th2 cytokine associated with T regulatory cell function, parasite expulsion and allergic airway inflammation. In many tumors IL-9…”
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B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animals by Mirza, Noweeda, Duque, Maria Adelaida, Dominguez, Ana Lucia, Schrum, Adam G, Dong, Haidong, Lustgarten, Joseph

“…T cell responses are compromised in the elderly. The B7-CD28 family receptors are critical in the regulation of immune responses. We evaluated whether the…”
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Systemic Targeting of CpG-ODN to the Tumor Microenvironment with Anti-neu-CpG Hybrid Molecule and T Regulatory Cell Depletion Induces Memory Responses in BALB-neuT Tolerant Mice by SHARMA, Sanjay, DOMINGUEZ, Ana Lucia, ZORRO MANRIQUE, Soraya, CAVALLO, Federica, SAKAGUCHI, Shimon, LUSTGARTEN, Joseph

“…We have shown that neu transgenic mice are immunotolerant and that immunizations with dendritic cells (DC) pulsed with neu-derived antigens were not able to…”
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