Search Results - "Domingos Possani, Lourival"

Colombian Scorpion Centruroides margaritatus : Purification and Characterization of a Gamma Potassium Toxin with Full-Block Activity on the hERG1 Channel by Beltrán-Vidal, José, Carcamo-Noriega, Edson, Pastor, Nina, Zamudio-Zuñiga, Fernando, Guerrero-Vargas, Jimmy Alexander, Castaño, Santiago, Possani, Lourival Domingos, Restano-Cassulini, Rita

“…The Colombian scorpion produces a venom considered of low toxicity. Nevertheless, there are known cases of envenomation resulting in cardiovascular disorders,…”
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Transcriptomic and Proteomic Analyses Reveal the Diversity of Venom Components from the Vaejovid Scorpion Serradigitus gertschi by Romero-Gutiérrez, Maria Teresa, Santibáñez-López, Carlos Eduardo, Jiménez-Vargas, Juana María, Batista, Cesar Vicente Ferreira, Ortiz, Ernesto, Possani, Lourival Domingos

“…To understand the diversity of scorpion venom, RNA from venomous glands from a sawfinger scorpion, , of the family Vaejovidae, was extracted and used for…”
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The Ca2+ Channel Blocker Verapamil Inhibits the In Vitro Activation and Function of T Lymphocytes: A 2022 Reappraisal by Veytia-Bucheli, José Ignacio, Alvarado-Velázquez, Den Alejandro, Possani, Lourival Domingos, González-Amaro, Roberto, Rosenstein, Yvonne

“…Ca2+ channel blockers (CCBs) are commonly used to treat different cardiovascular conditions. These drugs disrupt the intracellular Ca2+ signaling network,…”
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Comparative proteomic analysis of female and male venoms from the Mexican scorpion Centruroides limpidus: Novel components found by Cid Uribe, Jimena Isaias, Jiménez Vargas, Juana Maria, Ferreira Batista, Cesar Vicente, Zamudio Zuñiga, Fernando, Possani, Lourival Domingos

“…Venom from male and female scorpions of the species Centruroides limpidus were separated by HPLC and their molecular masses determined by mass spectrometry…”
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Targeting antigens to Dec-205 on dendritic cells induces a higher immune response in chickens: Hemagglutinin of avian influenza virus example by Jáuregui-Zúñiga, David, Pedraza-Escalona, Martha, Espino-Solís, Gerardo Pavel, Quintero-Hernández, Verónica, Olvera-Rodríguez, Alejandro, Díaz-Salinas, Marco Aurelio, López, Susana, Possani, Lourival Domingos

“…It is widely known that targeting a variety of antigens to the DEC-205 receptor on dendritic cells (DCs) significantly potentiate immunity. This communication…”
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Venom content and toxicity regeneration after venom gland depletion by electrostimulation in the scorpion Centruroides limpidus by Carcamo-Noriega, Edson Norberto, Possani, Lourival Domingos, Ortiz, Ernesto

“…The scorpion venom is a cocktail of many components. Its composition can exhibit a level of plasticity in response to different behavioral and environmental…”
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Antiseizure potential of peptides from the venom of social wasp Chartergellus communis against chemically-induced seizures by Lopes, Kamila Soares, Quintanilha, Maria Varela Torres, de Souza, Adolfo Carlos Barros, Zamudio-Zuñiga, Fernando, Possani, Lourival Domingos, Mortari, Márcia Renata

“…Epilepsy is one of the most common neurological diseases in the world. The objective of this research was to investigate a new peptide from the venom of the…”
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Antarease-like Zn-metalloproteases are ubiquitous in the venom of different scorpion genera by Ortiz, Ernesto, Rendón-Anaya, Martha, Rego, Solange Cristina, Schwartz, Elisabeth Ferroni, Possani, Lourival Domingos

“…The venoms of several scorpion species have long been associated with pancreatitis in animal models and humans. Antarease, a Zn-metalloprotease from Tityus…”
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Intraspecific variation of Centruroides sculpturatus scorpion venom from two regions of Arizona by Carcamo-Noriega, Edson Norberto, Olamendi-Portugal, Timoteo, Restano-Cassulini, Rita, Rowe, Ashlee, Uribe-Romero, Selene Jocelyn, Becerril, Baltazar, Possani, Lourival Domingos

“…This study investigated geographic variability in the venom of Centruroides sculpturatus scorpions from different biotopes. Venom from scorpions collected from…”
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Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K+ Channel KV1.2 and Small- and Intermediate-Conductance Ca2+-Activated K+ Channels KCa2.2 and KCa3.1 by Naseem, Muhammad Umair, Gurrola-Briones, Georgina, Romero-Imbachi, Margarita R., Borrego, Jesus, Carcamo-Noriega, Edson, Beltrán-Vidal, José, Zamudio, Fernando Z., Shakeel, Kashmala, Possani, Lourival Domingos, Panyi, Gyorgy

“…A novel peptide, Cm39, was identified in the venom of the scorpion Centruroides margaritatus. Its primary structure was determined. It consists of 37 amino…”
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Structural and functional characterization of toxic peptides purified from the venom of the Colombian scorpion Tityus macrochirus by Rincón-Cortés, Clara Andrea, Olamendi-Portugal, Timoteo, Carcamo-Noriega, Edson Norberto, Santillán, Edmundo González, Zuñiga, Fernando Zamudio, Reyes-Montaño, Edgar Antonio, Vega Castro, Nohora Angélica, Possani, Lourival Domingos

“…The soluble venom of the scorpion Tityus macrochirus was separated by chromatographic procedures and three homogeneous peptides were obtained and their primary…”
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An Alkaloid from Scorpion Venom: Chemical Structure and Synthesis by Banerjee, Shibdas, Gnanamani, Elumalai, Lynch, Stephen R, Zuñiga, Fernando Zamudio, Jiménez-Vargas, Juana María, Possani, Lourival Domingos, Zare, Richard N

“…While most scorpion venom components identified in the past are peptidic or proteinic in nature, we report here a new alkaloid isolated from the venom of the…”
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Of Seven New K+ Channel Inhibitor Peptides of Centruroides bonito, α-KTx 2.24 Has a Picomolar Affinity for Kv1.2 by Shakeel, Kashmala, Olamendi-Portugal, Timoteo, Naseem, Muhammad Umair, Becerril, Baltazar, Zamudio, Fernando Z., Delgado-Prudencio, Gustavo, Possani, Lourival Domingos, Panyi, Gyorgy

“…Seven new peptides denominated CboK1 to CboK7 were isolated from the venom of the Mexican scorpion Centruroides bonito and their primary structures were…”
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Unveiling the Protein Components of the Secretory-Venom Gland and Venom of the Scorpion Centruroides possanii (Buthidae) through Omic Technologies by García-Villalvazo, Patricia Elizabeth, Jiménez-Vargas, Juana María, Lino-López, Gisela Jareth, Meneses, Erika Patricia, Bermúdez-Guzmán, Manuel de Jesús, Barajas-Saucedo, Carlos Eduardo, Delgado Enciso, Iván, Possani, Lourival Domingos, Valdez-Velazquez, Laura Leticia

“…Centruroides possanii is a recently discovered species of “striped scorpion” found in Mexico. Certain species of Centruroides are known to be toxic to mammals,…”
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New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing by Saucedo, Alma Leticia, Flores-Solis, David, Rodríguez de la Vega, Ricardo C, Ramírez-Cordero, Belén, Hernández-López, Rogelio, Cano-Sánchez, Patricia, Noriega Navarro, Roxana, García-Valdés, Jesús, Coronas-Valderrama, Fredy, de Roodt, Adolfo, Brieba, Luis G, Domingos Possani, Lourival, del Río-Portilla, Federico

“…Scorpion venoms are a rich source of K(+) channel-blocking peptides. For the most part, they are structurally related small disulfide-rich proteins containing…”
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Characterization of two peptides isolated from the venom of social wasp Chartergellus communis (Hymenoptera: Vespidae): Influence of multiple alanine residues and C-terminal amidation on biological effects by Lopes, Kamila Soares, Campos, Gabriel Avohay Alves, Camargo, Luana Cristina, de Souza, Adolfo Carlos Barros, Ibituruna, Beatriz Vasconcelos, Magalhães, Ana Carolina Martins, da Rocha, Lucas Ferreira, Garcia, Alessa Bembom, Rodrigues, Mosar Correa, Ribeiro, Dagon Manoel, Costa, Michelle Cruz, López, Manuel Humberto Mera, Nolli, Luciana Marangni, Zamudio-Zuniga, Fernando, Possani, Lourival Domingos, Schwartz, Elisabeth Ferroni, Mortari, Márcia Renata

“…•Two peptides were characterized from the venom of the social wasp C. communis.•First time that a wasp's peptide with multiple alanines in their sequence is…”
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The new kappa-KTx 2.5 from the scorpion Opisthacanthus cayaporum by Camargos, Thalita Soares, Restano-Cassulini, Rita, Possani, Lourival Domingos, Peigneur, Steve, Tytgat, Jan, Schwartz, Carlos Alberto, Alves, Erica Maria C, de Freitas, Sonia Maria, Schwartz, Elisabeth Ferroni

“…► We describe the κ-KTx2.5 and show it is a blocker of hKv1.1, and hKv1.4 channels. ► CD spectra showed a predominance of α-helices at different temperatures…”
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Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation by Veytia-Bucheli, Jose Ignacio, Jimenez-Vargas, Juana Maria, Melchy-Perez, Erika Isabel, Sandoval-Hernandez, Monserrat Alba, Possani, Lourival Domingos, Rosenstein, Yvonne

“…BackgroundIn T cells, the Kv1.3 and the KCa3.1 potassium channels regulate the membrane potential and calcium homeostasis. Notably, during TEM cell activation,…”
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Novel monoclonal antibody against alphaX subunit from horse CD11c/CD18 integrin by Espino-Solis, Gerardo Pavel, Quintero-Hernandez, Veronica, Olvera-Rodriguez, Alejandro, Calderon-Amador, Juana, Pedraza-Escalona, Martha, Licea-Navarro, Alexei, Flores-Romo, Leopoldo, Possani, Lourival Domingos

“…The αX I-domain of the horse integrin CD11c was successfully expressed in Escherichia coli, purified, biochemically characterized and used as immunogen to…”
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Two Novel Ergtoxins, Blockers of K+-channels, Purified from the Mexican Scorpion Centruroides elegans elegans by Restano-Cassulini, Rita, Olamendi-Portugal, Timoteo, Zamudio, Fernando, Becerril, Baltazar, Possani, Lourival Domingos

“…Voltage-gated potassium channels of the ether-a-go-go related gene (ERG) family are implicated in many important cellular processes. Three such genes have been…”
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