Role of UBE2C in Brain Cancer Invasion and Dissemination

Role of UBE2C in Brain Cancer Invasion and Dissemination

Glioblastoma (GB) and brain metastases (BM) are the most common brain tumors in adults and are invariably associated with a dismal outcome. These highly malignant tumors share common features including increased invasion and migration of the primary or metastatic brain cancer cells, whose triggering...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences Vol. 24; no. 21; p. 15792
Main Authors: Domentean, Stefani, Paisana, Eunice, Cascão, Rita, Faria, Claudia C
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-11-2023
Subjects:
Apoptosis
Brain cancer
brain metastases (BM)
Brain research
brain tumors
Cancer therapies
Cell cycle
Chemotherapy
Development and progression
Disease
dissemination
Drug resistance
Enzymes
glioblastoma (GB)
Gliomas
invasion
Medical prognosis
Medical research
Melanoma
Metastasis
Mortality
Mutation
Proteins
Radiation therapy
Stem cells
Tumorigenesis
Tumors
Ubiquitin
ubiquitin-conjugating enzyme E2C (UBE2C)
Vorinostat
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glioblastoma (GB) and brain metastases (BM) are the most common brain tumors in adults and are invariably associated with a dismal outcome. These highly malignant tumors share common features including increased invasion and migration of the primary or metastatic brain cancer cells, whose triggering mechanisms are largely unknown. Emerging evidence has suggested that the ubiquitin-conjugating enzyme E2C (UBE2C), essential for controlling cell cycle progression, is overexpressed in diverse malignancies, including brain cancer. This review highlights the crucial role of UBE2C in brain tumorigenesis and its association with higher proliferative phenotype and histopathological grade, with autophagy and apoptosis suppression, epithelial-to-mesenchymal transition (EMT), invasion, migration, and dissemination. High expression of UBE2C has been associated with patients’ poor prognosis and drug resistance. UBE2C has also been proven as a promising therapeutic target, despite the lack of specific inhibitors. Thus, there is a need to further explore the role of UBE2C in malignant brain cancer and to develop effective targeted therapies for patients with this deadly disease.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242115792