Search Results - "Dombrowski, Yvonne"

Oligodendrocytes in Development, Myelin Generation and Beyond by Kuhn, Sarah, Gritti, Laura, Crooks, Daniel, Dombrowski, Yvonne

“…Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are generated from oligodendrocyte progenitor cells (OPC). OPC are…”
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QuPath: Open source software for digital pathology image analysis by Bankhead, Peter, Loughrey, Maurice B., Fernández, José A., Dombrowski, Yvonne, McArt, Darragh G., Dunne, Philip D., McQuaid, Stephen, Gray, Ronan T., Murray, Liam J., Coleman, Helen G., James, Jacqueline A., Salto-Tellez, Manuel, Hamilton, Peter W.

“…QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly, extensible, open-source solution for digital pathology and…”
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Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions by Dombrowski, Yvonne, Peric, Mark, Koglin, Sarah, Kammerbauer, Claudia, Göss, Christine, Anz, David, Simanski, Maren, Gläser, Regine, Harder, Jürgen, Hornung, Veit, Gallo, Richard L, Ruzicka, Thomas, Besch, Robert, Schauber, Jürgen

“…The proinflammatory cytokine interleukin-1β (IL-1β) plays a central role in the pathogenesis and the course of inflammatory skin diseases, including psoriasis…”
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Antimicrobial Peptides and Proinflammatory Cytokines in Periprosthetic Joint Infection by Gollwitzer, Hans, Dombrowski, Yvonne, Prodinger, Peter M, Peric, Mark, Summer, Burkhard, Hapfelmeier, Alexander, Saldamli, Belma, Pankow, Felix, von Eisenhart-Rothe, Rüdiger, Imhoff, Andreas B, Schauber, Jürgen, Thomas, Peter, Burgkart, Rainer, Banke, Ingo J

“…BACKGROUND:Differentiation between septic and aseptic loosening of joint replacements is essential for successful revision surgery, but reliable markers for…”
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The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination by McMurran, Christopher E., de la Fuente, Alerie Guzman, Penalva, Rosana, Menachem-Zidon, Ofra Ben, Dombrowski, Yvonne, Falconer, John, Gonzalez, Ginez A., Zhao, Chao, Krause, Fynn N., Young, Adam M. H., Griffin, Julian L., Jones, Clare A., Hollins, Claire, Heimesaat, Markus M., Fitzgerald, Denise C., Franklin, Robin J. M.

“…The microbiota is now recognized as a key influence on the host immune response in the central nervous system (CNS). As such, there has been some progress…”
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GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas by ROTH, Patrick, JUNKER, Markus, TRITSCHLER, Isabel, MITTELBRONN, Michel, DOMBROWSKI, Yvonne, BREIT, Samuel N, TABATABAI, Ghazaleh, WICK, Wolfgang, WELLER, Michael, WISCHHUSEN, Jörg

“…Growth and differentiation factor (GDF)-15 is a member of the transforming growth factor (TGF)-beta family. GDF-15 is necessary for the maintenance of…”
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Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination by de la Fuente, Alerie Guzman, Dittmer, Marie, Heesbeen, Elise J., de la Vega Gallardo, Nira, White, Jessica A., Young, Andrew, McColgan, Tiree, Dashwood, Amy, Mayne, Katie, Cabeza-Fernández, Sonia, Falconer, John, Rodriguez-Baena, Francisco Javier, McMurran, Christopher E., Inayatullah, Mohammed, Rawji, Khalil S., Franklin, Robin J. M., Dooley, James, Liston, Adrian, Ingram, Rebecca J., Tiwari, Vijay K., Penalva, Rosana, Dombrowski, Yvonne, Fitzgerald, Denise C.

“…Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency…”
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Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis by Peric, Mark, Koglin, Sarah, Dombrowski, Yvonne, Gross, Katrin, Bradac, Eva, Büchau, Amanda, Steinmeyer, Andreas, Zügel, Ulrich, Ruzicka, Thomas, Schauber, Jürgen

“…Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic…”
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Regulatory T cells limit age-associated retinal inflammation and neurodegeneration by Llorián-Salvador, María, de Fuente, Alerie G, McMurran, Christopher E, Dashwood, Amy, Dooley, James, Liston, Adrian, Penalva, Rosana, Dombrowski, Yvonne, Stitt, Alan W, Fitzgerald, Denise C

“…Ageing is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the developed countries. These conditions…”
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Macrophage Migration Inhibitory Factor Contributes to the Immune Escape of Ovarian Cancer by Down-Regulating NKG2D by Krockenberger, Mathias, Dombrowski, Yvonne, Weidler, Claudia, Ossadnik, Monika, Honig, Arnd, Hausler, Sebastian, Voigt, Heike, Becker, Jurgen C, Leng, Lin, Steinle, Alexander, Weller, Michael, Bucala, Richard, Dietl, Johannes, Wischhusen, Jorg

“…The proinflammatory cytokine macrophage migration inhibitory factor (MIF) stimulates tumor cell proliferation, migration, and metastasis; promotes tumor…”
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Characterization of a murine mixed neuron-glia model and cellular responses to regulatory T cell-derived factors by Dittmer, Marie, Young, Andrew, O'Hagan, Thomas, Eleftheriadis, George, Bankhead, Peter, Dombrowski, Yvonne, Medina, Reinhold J, Fitzgerald, Denise C

“…One of the unmet clinical needs in demyelinating diseases such as Multiple Sclerosis (MS) is to provide therapies that actively enhance the process of myelin…”
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Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation by Kodji, Xenia, Kee, Zizheng, McKenna, Robyn, de Sousa Valente, Joao, Ravenscroft, Harriet, McMillan, Hayley, Gamble, John, Dombrowski, Yvonne, Moynagh, Paul, Brough, David, Lundy, Fionnuala T., Brain, Susan D., El Karim, Ikhlas A.

“…This study investigates the role of transient receptor potential ankyrin 1 (TRPA1) in murine temporomandibular joint (TMJ) inflammatory hyperalgesia and the…”
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UV-B–triggered induction of vitamin D3 metabolism differentially affects antimicrobial peptide expression in keratinocytes by Peric, Mark, PhD, Lehmann, Bodo, PhD, Vashina, Gabriela, MD, Dombrowski, Yvonne, PhD, Koglin, Sarah, Meurer, Michael, MD, Ruzicka, Thomas, MD, Schauber, Jürgen, MD

“…[...]HBD2 induction was restored when vitamin D3 synthesis was inhibited by ketoconazole. Importantly, this system is so robust that silencing of CYP27B1 to…”
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Pathogenic DNA: Cytosolic DNA promotes inflammation in psoriasis by Schauber, Jürgen, Dombrowski, Yvonne, Besch, Robert

“…Comment on: Dombrowski Y, et al. Sci Transl Med 2011; 3:82ra38…”
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Impact of vitamin D3 on cutaneous immunity and antimicrobial peptide expression by Antal, Attila S., Dombrowski, Yvonne, Koglin, Sarah, Ruzicka, Thomas, Schauber, Jürgen

“…Antimicrobial peptides (AMPs) are effectors of cutaneous innate immunity and protect primarily against microbial infections. An array of AMPs can be found in…”
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Innate and adaptive immune mechanisms regulating central nervous system remyelination by Creswell, Richard, Dombrowski, Yvonne

“…Neuroinflammation is a hallmark of many neurodegenerative diseases and is considered their underlying cause. However, certain aspects of neuroinflammation…”
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Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis by Dombrowski, Yvonne, Schauber, Jürgen

“…:  Epidermal keratinocytes produce and secrete antimicrobial peptides (AMPs) that subsequently form a chemical shield on the skin surface. Cathelicidins are…”
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Aging impairs peritoneal but not bone marrow‐derived macrophage phagocytosis by Linehan, Eimear, Dombrowski, Yvonne, Snoddy, Rachel, Fallon, Padraic G., Kissenpfennig, Adrien, Fitzgerald, Denise C.

“…Summary Aging results in deterioration of the immune system, which is associated with increased susceptibility to infection and impaired wound healing in the…”
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Regulatory T cells promote myelin regeneration in the central nervous system by Dombrowski, Yvonne, O'Hagan, Thomas, Dittmer, Marie, Penalva, Rosana, Mayoral, Sonia R, Bankhead, Peter, Fleville, Samara, Eleftheriadis, George, Zhao, Chao, Naughton, Michelle, Hassan, Rachel, Moffat, Jill, Falconer, John, Boyd, Amanda, Hamilton, Peter, Allen, Ingrid V, Kissenpfennig, Adrien, Moynagh, Paul N, Evergren, Emma, Perbal, Bernard, Williams, Anna C, Ingram, Rebecca J, Chan, Jonah R, Franklin, Robin J M, Fitzgerald, Denise C

“…Regeneration of myelin is a dynamic, yet enigmatic process. Dombrowski et al. uncover a central role for regulatory T (T reg ) cells in driving oligodendrocyte…”
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Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment by Tillack, Cornelia, Ehmann, Laura Maximiliane, Friedrich, Matthias, Laubender, Rüdiger P, Papay, Pavol, Vogelsang, Harald, Stallhofer, Johannes, Beigel, Florian, Bedynek, Andrea, Wetzke, Martin, Maier, Harald, Koburger, Maria, Wagner, Johanna, Glas, Jürgen, Diegelmann, Julia, Koglin, Sarah, Dombrowski, Yvonne, Schauber, Jürgen, Wollenberg, Andreas, Brand, Stephan

“…We analysed incidence, predictors, histological features and specific treatment options of anti-tumour necrosis factor α (TNF-α) antibody-induced psoriasiform…”
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