Search Results - "Dombrowski, Anne W."

Apicidin: A Novel Antiprotozoal Agent that Inhibits Parasite Histone Deacetylase by Darkin-Rattray, Sandra J., Gurnett, Anne M., Myers, Robert W., Dulski, Paula M., Crumley, Tami M., Allocco, John J., Cannova, Christine, Meinke, Peter T., Colletti, Steven L., Bednarek, Maria A., Singh, Sheo B., Goetz, Michael A., Dombrowski, Anne W., Polishook, Jon D., Schmatz, Dennis M.

“…A novel fungal metabolite, apicidin [cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2- amino-8-oxodecanoyl)], that exhibits potent, broad…”
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Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites by SINGH, Sheo B, JAYASURIYA, Hiranthi, FELOCK, Peter J, HAZUDA, Daria J, DEWEY, Raymond, POLISHOOK, Jon D, DOMBROWSKI, Anne W, ZINK, Deborah L, ZIQIANG GUAN, COLLADO, Javier, PLATAS, Gonzalo, PELAEZ, Fernando

“…HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition is one of the most promising new drug strategies for anti-retroviral therapy,…”
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Isolation and Structure of Antagonists of Chemokine Receptor (CCR5) by Jayasuriya, Hiranthi, Herath, Kithsiri B, Ondeyka, John G, Polishook, Jon D, Bills, Gerald F, Dombrowski, Anne W, Springer, Marty S, Siciliano, Sal, Malkowitz, Lorraine, Sanchez, Manuel, Guan, Ziqiang, Tiwari, Suroojnauth, Stevenson, Dennis W, Borris, Robert P, Singh, Sheo B

“…Human CCR5 is a G-coupled receptor that binds to the envelope protein gp120 and CD4 and mediates the HIV-1 viral entry into the cells. The blockade of this…”
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Novel Sesquiterpenoids from the Fermentation of Xylaria persicaria Are Selective Ligands for the NPY Y5 Receptor by SMITH, Cameron J., MORIN, Nancy R., BILLS, Gerald F., DOMBROWSKI, Anne W., SALITURO, Gino M., SMITH, Scott K., ZHAO, Annie, MACNEIL, Douglas J.

“…Neuropeptide Y (NPY) is a polypeptide found in the peripheral and central nervous system and is involved in the regulation of feeding. Antagonists of NPY…”
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Identification of Diverse Microbial Metabolites as Potent Inhibitors of HIV-1 Tat Transactivation by Jayasuriya, Hiranthi, Zink, Deborah L., Polishook, Jon D., Bills, Gerald F., Dombrowski, Anne W., Genilloud, Olga, Pelaez, Fernando F., Herranz, Lucia, Quamina, Donette, Lingham, Russell B., Danzeizen, Renee, Graham, Pia L., Tomassini, Joanne E., Singh, Sheo B.

“…HIV‐1 Tat is one of six regulatory proteins that are required for viral replication and is an attractive target for the development of new anti‐HIV agents…”
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Nodulisporic Acid A, a Novel and Potent Insecticide from a Nodulisporium Sp. Isolation, Structure Determination, and Chemical Transformations by Ondeyka, John G, Helms, Gregory L, Hensens, Otto D, Goetz, Michael A, Zink, Deborah L, Tsipouras, Athanasios, Shoop, Wesley L, Slayton, Lyndia, Dombrowski, Anne W, Polishook, Jon D, Ostlind, Dan A, Tsou, Nancy N, Ball, Richard G, Singh, Sheo B

“…The potent insecticidal agent nodulisporic acid A (1a), representative of a new class of indole terpenes, was isolated from fermentations of a Nodulisporium…”
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Isolation, Structure, and Coccidiostat Activity of Coccidiostatin A by Jayasuriya, Hiranthi, Guan, Ziqiang, Dombrowski, Anne W, Bills, Gerald F, Polishook, Jon D, Jenkins, Rosalind G, Koch, Leslie, Crumley, Tami, Tamas, Dubois, Michelle, Misura, Andrew, Darkin-Rattray, Sandra J, Gregory, Lynn, Singh, Sheo B

“…Coccidiosis is one of the more common and costly diseases in poultry that is caused by various Eimeria species. In our quest to discover coccidiostats from…”
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Isolation and Insecticidal/Anthelmintic Activity of Xanthonol, a Novel Bis-xanthone, from a Non-sporulating Fungal species by Ondeyka, John G, Dombrowski, Anne W, Polishook, Jon P, Felcetto, Tom, Shoop, Wesley L, Guan, Ziqiang, Singh, Sheo B

“…Xanthonol, a novel dimeric xanthone, was isolated from a fermentation broth of a non-sporulating fungal species using Sephadex LH20 followed by HPLC and the…”
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Isolation and Structures of Novel Fungal Metabolites as Chemokine Receptor (CCR2) Antagonists by Herath, Kithsiri B, Jayasuriya, Hiranthi, Ondeyka, John G, Polishook, Jon D, Bills, Gerald F, Dombrowski, Anne W, Cabello, Angeles, Vicario, Pasquale P, Zweerink, Hans, Guan, Ziqiang, Singh, Sheo B

“…The chemokine receptor, CCR2, is predominantly expressed on monocytes/macrophages, and on a subset of memory T cells. It binds to several CC type chemokines of…”
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Isolation, Structure, and HIV-1 Integrase Inhibitory Activity of Cytosporic Acid, a Fungal Metabolite Produced by a Cytospora sp by Jayasuriya, Hiranthi, Guan, Ziqiang, Polishook, Jon D, Dombrowski, Anne W, Felock, Peter J, Hazuda, Daria J, Singh, Sheo B

“…HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition has the potential to lead to an anti-retroviral therapy that has advantages…”
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Isolation, Structure, Absolute Stereochemistry, and HIV-1 Integrase Inhibitory Activity of Integrasone, a Novel Fungal Polyketide by Herath, Kithsiri B, Jayasuriya, Hiranthi, Bills, Gerald F, Polishook, Jon D, Dombrowski, Anne W, Guan, Ziqiang, Felock, Peter J, Hazuda, Daria J, Singh, Sheo B

“…HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition is one of the most promising new drug targets for anti-retroviral therapy with…”
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Steroidal and Triterpenoidal Fungal Metabolites as Ligands of Liver X Receptors by Ondeyka, John G, Jayasuriya, Hiranthi, Herath, Kithsiri B, Guan, Ziqiang, Schulman, Marvin, Collado, Javier, Dombrowski, Anne W, Kwon, Soojin S, McCallum, Christine, Sharma, Neelam, MacNaul, Karen, Hayes, Nancy, Menke, John G, Singh, Sheo B

“…Cholesterol homeostasis is tightly controlled process that involves a variety of regulators including liver X receptors (LXR). Agonists of LXR are expected to…”
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Isolation, structure and HIV-1 integrase inhibitory activity of exophillic acid, a novel fungal metabolite from Exophiala pisciphila by Ondeyka, John G, Zink, Deborah L, Dombrowski, Anne W, Polishook, Jon D, Felock, Peter J, Hazuda, Daria J, Singh, Sheo B

“…HIV-1 integrase is one of the three enzymes that are critical for replication and spread of HIV and its inhibition is one of the most promising new drug…”
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Structure and Chemistry of Apicidins, a Class of Novel Cyclic Tetrapeptides without a Terminal α-Keto Epoxide as Inhibitors of Histone Deacetylase with Potent Antiprotozoal Activities by Singh, Sheo B., Zink, Deborah L., Liesch, Jerrold M., Mosley, Ralph T., Dombrowski, Anne W., Bills, Gerald F., Darkin-Rattray, Sandra J., Schmatz, Dennis M., Goetz, Michael A.

“…Apicidins are a class of cyclic tetrapeptides that do not contain the classical electrophilic α-keto epoxide yet are potent (nM) inhibitors of histone…”
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The "FERMEX" method for metabolite-enriched fungal extracts by Bills, Gerald F, Dombrowski, Anne W, Goetz, Michael A

“…The FERMEX (Fermentation Extract) program was a highly successful source of microbial natural product molecules for pharmaceutical lead discovery. The program…”
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Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase by Singh, Sheo B., Zink, Deborah L., Goetz, Michael A., Dombrowski, Anne W., Polishook, Jon D., Hazuda, Daria J.

“…Integration is an essential step in HIV replication and is catalyzed by an enzyme called integrase. We have isolated equisetin ( 1a), and a novel opposite…”
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Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase by Singh, Sheo B, Herath, Kithsiri, Guan, Ziqiang, Zink, Deborah L, Dombrowski, Anne W, Polishook, Jon D, Silverman, Keith C, Lingham, Russell B, Felock, Peter J, Hazuda, Daria J

“…[structure: see text]. Integramides A and B are two novel 16-mer linear peptides rich in C(alpha)-methyl amino acids that were isolated from fungal extracts of…”
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Integramides A and B, Two Novel Non-Ribosomal Linear Peptides Containing Nine C α-Methyl Amino Acids Produced by Fungal Fermentations That Are Inhibitors of HIV-1 Integrase by Singh, Sheo B, Herath, Kithsiri, Guan, Ziqiang, Zink, Deborah L, Dombrowski, Anne W, Polishook, Jon D, Silverman, Keith C, Lingham, Russell B, Felock, Peter J, Hazuda, Daria J

“…Integramides A and B are two novel 16-mer linear peptides rich in C α-methyl amino acids that were isolated from fungal extracts of Dendrodochium sp. by…”
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Isolation and structure of nodulisporic acid A1 and A2, novel insecticides from a Nodulisporium sp by Hensens, Otto D., Ondeyka, John G., Dombrowski, Anne W., Ostlind, Dan A., Zink, Deborah L.

“…The isolation and structure elucidation of two novel indole terpene insecticides nodulisporic acid A1(2) and A2 (3) from a Nodulisporium sp. are reported. In…”
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Integracides: tetracyclic triterpenoid inhibitors of HIV-1 integrase produced by Fusarium sp by Singh, Sheo B, Zink, Deborah L, Dombrowski, Anne W, Polishook, Jon D, Ondeyka, John G, Hirshfield, Jorden, Felock, Peter, Hazuda, Daria J

“…HIV-1 integrase is a critical enzyme in the replication of HIV-1. It is absent in the host cells and therefore is a good target for treatment of HIV-1…”
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