Search Results - "Dombro, Roy S."

Elevation of glutathione levels by ammonium ions in primary cultures of rat astrocytes by Murthy, Ch R.K, Bender, Alex S, Dombro, Roy S, Bai, Ge, Norenberg, Michael D

“…It is well established that ammonia is detoxified in the brain to form glutamine and that astrocytes play a major role in this process. The synthesis of…”
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Synthesis of L-cystathionine and D-allocystathionine by Snow, Mary L, Dombro, Roy S, Ressler, Charlotte

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Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain by Itzhak, Yossef, Roig-Cantisano, Ana, Dombro, Roy S., Norenberg, Michael D.

“…We investigated the role of brain peripheral-type benzodiazepine receptors (PBRs) and pregnenolone (a product of PBRs activation) in hepatic encephalopathy…”
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Association between cell swelling and glycogen content in cultured astrocytes by Dombro, Roy S., Bender, Alex S., Norenberg, Michael D.

“…Treatment of cultured rat astrocytes with hypotonic media or with 1 mM glutamate for 90 min caused cell swelling and a significant increase in glycogen…”
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The action of ammonia on astrocyte glycogen and glycogenolysis by DOMBRO, R. S, HUTSON, D. G, NORENBERG, M. D

“…Most of the brain glycogen, a major energy reserve that can be mobilized in response to increased neuronal activity, resides in the astrocyte, the site of the…”
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Tryptophan and hepatic coma by Ono, J, Hutson, D G, Dombro, R S, Levi, J U, Livingstone, A, Zeppa, R

“…To clarify the involvement of tryptophan in the pathogenesis of hepatic coma, plasma and cerebrospinal fluid (CSF) tryptophan was studied in three patient…”
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A modified procedure for the determination of 5-hydroxyindoleacetic acid in the urine and cerebrospinal fluid of patients with hepatic cirrhosis by Dombro, R S, Hutson, D G

“…A method has been developed for the separation of 5-hydroxyindoleacetic acid from substances in urine and cerebrospinal fluid which interfere with its…”
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Lowering of plasma free tryptophan in normal and portacaval shunt dogs by Miyai, M, Hutson, D G, Dombro, R S

“…The purpose of this study was to develop a method which would produce immediate and sustained lowering of plasma free tryptophan. Glucose, insulin, and…”
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Insulin degradation in hepatic cirrhosis by Ono, J, Hutson, D G, Dombro, R S, Zeppa, R, Katsuki, T

“…Hepatic insulinase activity was studied in cirrhosis in an attempt to explain the hyperinsulinemia known to occur in this disease. Liver tissue was obtained…”
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A possible hepatic factor in the control of plasma free fatty acid levels by Bernal, R, Hutson, D G, Dombro, R S, Livingstone, A, Levi, J U, Zeppa, R

“…Insulin acts as a regulator of lipid metabolism by inhibiting the rate of lipolysis. Hyperinsulinemia, produced by the peripheral infusion of glucose,…”
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A longitudinal study of tryptophan involvement in hepatic coma by Hutson, D G, Ono, J, Dombro, R S, Levi, J U, Livingstone, A, Zeppa, R

“…Previous cross-sectional studies have demonstrated that hepatic coma is associated with abnormally high levels of plasma free tryptophan. Establishment of a…”
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