Search Results - "Dombert, Benjamin"

Insulin-like growth factor 1 in diabetic neuropathy and amyotrophic lateral sclerosis by Rauskolb, Stefanie, Dombert, Benjamin, Sendtner, Michael

“…Abstract Insulin-like growth factor 1 (IGF-1) is a pluripotent growth factor with multiple functions in the peripheral and central nervous system. It supports…”
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Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneurons by Dombert, Benjamin, Sivadasan, Rajeeve, Simon, Christian M, Jablonka, Sibylle, Sendtner, Michael

“…Spinal muscular atrophy (SMA) is caused by deficiency of the ubiquitously expressed survival motoneuron (SMN) protein. SMN is crucial component of a complex…”
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The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons by Lüningschrör, Patrick, Werner, Georg, Stroobants, Stijn, Kakuta, Soichiro, Dombert, Benjamin, Sinske, Daniela, Wanner, Renate, Lüllmann-Rauch, Renate, Wefers, Benedikt, Wurst, Wolfgang, D’Hooge, Rudi, Uchiyama, Yasuo, Sendtner, Michael, Haass, Christian, Saftig, Paul, Knöll, Bernd, Capell, Anja, Damme, Markus

“…Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and…”
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Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function by Briese, Michael, Saal-Bauernschubert, Lena, Lüningschrör, Patrick, Moradi, Mehri, Dombert, Benjamin, Surrey, Verena, Appenzeller, Silke, Deng, Chunchu, Jablonka, Sibylle, Sendtner, Michael

“…Abstract Protein inclusions containing the RNA-binding protein TDP-43 are a pathological hallmark of amyotrophic lateral sclerosis and other neurodegenerative…”
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Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease by Lüningschrör, Patrick, Binotti, Beyenech, Dombert, Benjamin, Heimann, Peter, Perez-Lara, Angel, Slotta, Carsten, Thau-Habermann, Nadine, R. von Collenberg, Cora, Karl, Franziska, Damme, Markus, Horowitz, Arie, Maystadt, Isabelle, Füchtbauer, Annette, Füchtbauer, Ernst-Martin, Jablonka, Sibylle, Blum, Robert, Üçeyler, Nurcan, Petri, Susanne, Kaltschmidt, Barbara, Jahn, Reinhard, Kaltschmidt, Christian, Sendtner, Michael

“…Autophagy-mediated degradation of synaptic components maintains synaptic homeostasis but also constitutes a mechanism of neurodegeneration. It is unclear how…”
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Mechanisms for axon maintenance and plasticity in motoneurons: alterations in motoneuron disease by Jablonka, Sibylle, Dombert, Benjamin, Asan, Esther, Sendtner, Michael

“…In motoneuron disease and other neurodegenerative disorders, the loss of synapses and axon branches occurs early but is compensated by sprouting of neighboring…”
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BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221) by Dombert, Benjamin, Balk, Stefanie, Lüningschrör, Patrick, Moradi, Mehri, Sivadasan, Rajeeve, Saal-Bauernschubert, Lena, Jablonka, Sibylle

“…Spontaneous Ca2+ transients and actin dynamics in primary motoneurons correspond to cellular differentiation such as axon elongation and growth cone formation…”
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R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy by Tejero, Rocio, Balk, Stefanie, Franco-Espin, Julio, Ojeda, Jorge, Hennlein, Luisa, Drexl, Hans, Dombert, Benjamin, Clausen, Jan-Dierk, Torres-Benito, Laura, Saal-Bauernschubert, Lena, Blum, Robert, Briese, Michael, Appenzeller, Silke, Tabares, Lucia, Jablonka, Sibylle

“…Neurotransmission defects and motoneuron degeneration are hallmarks of spinal muscular atrophy, a monogenetic disease caused by the deficiency of the SMN…”
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Axonal and dendritic localization of mRNAs for glycogen-metabolizing enzymes in cultured rodent neurons by Pfeiffer-Guglielmi, Brigitte, Dombert, Benjamin, Jablonka, Sibylle, Hausherr, Vanessa, van Thriel, Christoph, Schöbel, Nicole, Jansen, Ralf-Peter

“…Localization of mRNAs encoding cytoskeletal or signaling proteins to neuronal processes is known to contribute to axon growth, synaptic differentiation and…”
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Neurodegenerative Mutation in Cytoplasmic Dynein Alters Its Organization and Dynein-Dynactin and Dynein-Kinesin Interactions by Deng, Wenhan, Garrett, Caroline, Dombert, Benjamin, Soura, Violetta, Banks, Gareth, Fisher, Elizabeth M.C., van der Brug, Marcel P., Hafezparast, Majid

“…A single amino acid change, F580Y (Legs at odd angles (Loa), Dync1h1Loa), in the highly conserved and overlapping homodimerization, intermediate chain, and…”
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Differential roles of α-, β-, and γ-actin in axon growth and collateral branch formation in motoneurons by Moradi, Mehri, Sivadasan, Rajeeve, Saal, Lena, Lüningschrör, Patrick, Dombert, Benjamin, Rathod, Reena Jagdish, Dieterich, Daniela C, Blum, Robert, Sendtner, Michael

“…Axonal branching and terminal arborization are fundamental events during the establishment of synaptic connectivity. They are triggered by assembly of actin…”
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Activation of TRESK channels by the inflammatory mediator lysophosphatidic acid balances nociceptive signalling by Kollert, Sina, Dombert, Benjamin, Döring, Frank, Wischmeyer, Erhard

“…In dorsal root ganglia (DRG) neurons TRESK channels constitute a major current component of the standing outward current IK SO . A prominent physiological role…”
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Impaired Local Translation of β-actin mRNA in Ighmbp2-Deficient Motoneurons: Implications for Spinal Muscular Atrophy with respiratory Distress (SMARD1) by Surrey, Verena, Zöller, Caren, Lork, Alicia Andrea, Moradi, Mehri, Balk, Stefanie, Dombert, Benjamin, Saal-Bauernschubert, Lena, Briese, Michael, Appenzeller, Silke, Fischer, Utz, Jablonka, Sibylle

“…•Ighmbp2 deficiency marginally affects differentiation and function of primary motoneurons.•Ighmbp2 deficiency leads to delayed β-actin protein biosynthesis at…”
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Loss measurement of magnetic components under real application conditions by Kleeb, Thiemo, Dombert, Benjamin, Araujo, Samuel, Zacharias, Peter

“…Due to the increasing demand for highly efficient power electronic converters, a detailed design targeting each individual circuit component like magnetic…”
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Differential roles of [alpha]-, [Beta]-, and [gamma]-actin in axon growth and collateral branch formation in motoneurons by Moradi, Mehri, Sivadasan, Rajeeve, Saal, Lena, Lüningschrör, Patrick, Dombert, Benjamin, Rathod, Reena Jagdish, Dieterich, Daniela C, Blum, Robert, Sendtner, Michael

“…Axonal branching and terminal arborization are fundamental events during the establishment of synaptic connectivity. They are triggered by assembly of actin…”
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Role of Na(v)1.9 in activity-dependent axon growth in motoneurons by Subramanian, Narayan, Wetzel, Andrea, Dombert, Benjamin, Yadav, Preeti, Havlicek, Steven, Jablonka, Sibylle, Nassar, Mohammed A, Blum, Robert, Sendtner, Michael

“…Spontaneous neural activity promotes axon growth in many types of developing neurons, including motoneurons. In motoneurons from a mouse model of spinal…”
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Role of Nav1.9 in activity-dependent axon growth in motoneurons by SUBRAMANIAN, Narayan, WETZEL, Andrea, DOMBERT, Benjamin, YADAV, Preeti, HAVLICEK, Steven, JABLONKA, Sibylle, NASSAR, Mohammed A, BLUM, Robert, SENDTNER, Michael

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Neurofilament depletion improves microtubule dynamics via modulation of Stat3/stathmin signaling by Yadav, Preeti, Selvaraj, Bhuvaneish T., Bender, Florian L. P., Behringer, Marcus, Moradi, Mehri, Sivadasan, Rajeeve, Dombert, Benjamin, Blum, Robert, Asan, Esther, Sauer, Markus, Julien, Jean-Pierre, Sendtner, Michael

“…In neurons, microtubules form a dense array within axons, and the stability and function of this microtubule network is modulated by neurofilaments…”
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Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy by Simon, Christian M., Rauskolb, Stefanie, Gunnersen, Jennifer M., Holtmann, Bettina, Drepper, Carsten, Dombert, Benjamin, Braga, Massimiliano, Wiese, Stefan, Jablonka, Sibylle, Pühringer, Dirk, Zielasek, Jürgen, Hoeflich, Andreas, Silani, Vincenzo, Wolf, Eckhard, Kneitz, Susanne, Sommer, Claudia, Toyka, Klaus V., Sendtner, Michael

“…Diabetic neuropathy (DNP), afflicting sensory and motor nerve fibers, is a major complication in diabetes. The underlying cellular mechanisms of axon…”
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BDNF/trkB Induction of Calcium Transients through Ca v 2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221) by Dombert, Benjamin, Balk, Stefanie, Lüningschrör, Patrick, Moradi, Mehri, Sivadasan, Rajeeve, Saal-Bauernschubert, Lena, Jablonka, Sibylle

“…Spontaneous Ca transients and actin dynamics in primary motoneurons correspond to cellular differentiation such as axon elongation and growth cone formation…”
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