Multicentre Study Into the Use of Polyethylene Glycol With Electrolytes Over at Least 6 Months to Treat Constipation in Paediatric Populations
Background: Constipation is a common clinical problem in children, for which the first‐line therapeutic options are osmotic laxatives, mainly polyethylene glycol (PEG). These treatments are often prescribed for short or limited periods, with progressive treatment withdrawal often resulting in relaps...
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| Published in: | JPGN reports Vol. 4; no. 4; pp. e353 - n/a |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Philadelphia, PA
Lippincott Williams & Wilkins, Inc
01-11-2023
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Background:
Constipation is a common clinical problem in children, for which the first‐line therapeutic options are osmotic laxatives, mainly polyethylene glycol (PEG). These treatments are often prescribed for short or limited periods, with progressive treatment withdrawal often resulting in relapses. However, there are a few studies into the long‐term use (≥6 months) of PEG 3350 with electrolytes (PEG+E) in terms of the patients’ clinical evolution.
Objectives:
To assess bowel movement and other relevant symptoms in children with constipation receiving PEG+E (≥6 months), as well as parent/caregiver satisfaction with this treatment.
Methods:
A retrospective, observational, descriptive, longitudinal, and multicentre study was carried out on 74 children diagnosed with functional constipation (ROME IV criteria) who had received PEG+E (≥6 months). Bowel control was assessed using the Bristol stool scale, and the parent's/caregiver's perception of the treatment was also evaluated employing a nonvalidated questionnaire.
Results:
Children with an average duration of constipation >1 year experienced a significant improvement in bowel movements and stool consistency when using PEG+E. The mean duration of use was 18.6 (±13.4) months, without the need to adjust the dose for weight. All clinical symptoms improved significantly except bloating, and all the parents/caregivers confirmed these clinical improvements.
Conclusions:
Children treated with PEG+E (≥6 months) normalised their bowel movements, improving the clinical symptoms related to constipation in the absence of serious advert events or the need for dosage adjustments due to weight gain. Parents/caregivers reported good satisfaction with PEG+E treatment. |
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| Bibliography: | The authors report no conflicts of interest. This study was supported by Norgine S.L. to cover the costs of external medical writing services for the preparation of this article. Norgine holds the marketing authorisation for paediatric Movicol (polyethylene glycol 3350 with electrolytes). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 2691-171X 2691-171X |
| DOI: | 10.1097/PG9.0000000000000353 |