Search Results - "Domínguez, Jorge N."

Atrial myocardium derives from the posterior region of the second heart field, which acquires left-right identity as Pitx2c is expressed by Galli, Daniela, Domínguez, Jorge N, Zaffran, Stephane, Munk, Andrew, Brown, Nigel A, Buckingham, Margaret E

“…Splanchnic mesoderm in the region described as the second heart field (SHF) is marked by Islet1 expression in the mouse embryo. The anterior part of this…”
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MiR-195 enhances cardiomyogenic differentiation of the proepicardium/septum transversum by Smurf1 and Foxp1 modulation by Dueñas, Angel, Expósito, Almudena, Muñoz, María del Mar, de Manuel, María José, Cámara-Morales, Andrea, Serrano-Osorio, Fabio, García-Padilla, Carlos, Hernández-Torres, Francisco, Domínguez, Jorge N., Aránega, Amelia, Franco, Diego

“…Cardiovascular development is a complex developmental process in which multiple cell lineages are involved, namely the deployment of first and second heart…”
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Differential chamber-specific expression and regulation of long non-coding RNAs during cardiac development by García-Padilla, Carlos, Domínguez, Jorge N., Aránega, Amelia E., Franco, Diego

“…Cardiovascular development is governed by a complex interplay between inducting signals such as Bmps and Fgfs leading to activation of cardiac specific…”
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Tbx1 Coordinates Addition of Posterior Second Heart Field Progenitor Cells to the Arterial and Venous Poles of the Heart by Rana, M Sameer, Théveniau-Ruissy, Magali, De Bono, Christopher, Mesbah, Karim, Francou, Alexandre, Rammah, Mayyasa, Domínguez, Jorge N, Roux, Marine, Laforest, Brigitte, Anderson, Robert H, Mohun, Timothy, Zaffran, Stephane, Christoffels, Vincent M, Kelly, Robert G

“…RATIONALE:Cardiac progenitor cells from the second heart field (SHF) contribute to rapid growth of the embryonic heart, giving rise to right ventricular and…”
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The Tbx2+ Primary Myocardium of the Atrioventricular Canal Forms the Atrioventricular Node and the Base of the Left Ventricle by Aanhaanen, Wim T.J, Brons, Janynke F, Domínguez, Jorge N, Rana, M Sameer, Norden, Julia, Airik, Rannar, Wakker, Vincent, de Gier-de Vries, Corrie, Brown, Nigel A, Kispert, Andreas, Moorman, Antoon F.M, Christoffels, Vincent M

“…The primary myocardium of the embryonic heart, including the atrioventricular canal and outflow tract, is essential for septation and valve formation. In the…”
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Embryonic Tbx3 + cardiomyocytes form the mature cardiac conduction system by progressive fate restriction by Mohan, Rajiv A, Mommersteeg, Mathilda T M, Domínguez, Jorge N, Choquet, Caroline, Wakker, Vincent, de Gier-de Vries, Corrie, Boink, Gerard J J, Boukens, Bastiaan J, Miquerol, Lucile, Verkerk, Arie O, Christoffels, Vincent M

“…A small network of spontaneously active Tbx3 cardiomyocytes forms the cardiac conduction system (CCS) in adults. Understanding the origin and mechanism of…”
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Dissecting the Complexity of Early Heart Progenitor Cells by Sendra, Miquel, Domínguez, Jorge N, Torres, Miguel, Ocaña, Oscar H

“…Early heart development depends on the coordinated participation of heterogeneous cell sources. As pioneer work from Adriana C. Gittenberger-de Groot…”
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Differential Spatio-Temporal Regulation of T-Box Gene Expression by microRNAs during Cardiac Development by Alzein, Mohamad, Lozano-Velasco, Estefanía, Hernández-Torres, Francisco, García-Padilla, Carlos, Domínguez, Jorge N., Aránega, Amelia, Franco, Diego

“…Cardiovascular development is a complex process that starts with the formation of symmetrically located precardiac mesodermal precursors soon after…”
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Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development by Domínguez, Jorge N., de la Rosa, Ángel, Navarro, Francisco, Franco, Diego, Aránega, Amelia E.

“…Aims The aim of this study was to analyse the mRNA expression levels and protein distribution of the cardiac sodium channel Scn5a/Nav1.5 during mouse…”
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Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis by de la Rosa, Angel J, Domínguez, Jorge N, Sedmera, David, Sankova, Bara, Hove-Madsen, Leif, Franco, Diego, Aránega, Amelia E

“…Ion channel remodelling and ventricular conduction system (VCS) alterations play relevant roles in the generation of cardiac arrhythmias, but the interaction…”
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A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics by Le Garrec, Jean-François, Domínguez, Jorge N, Desgrange, Audrey, Ivanovitch, Kenzo D, Raphaël, Etienne, Bangham, J Andrew, Torres, Miguel, Coen, Enrico, Mohun, Timothy J, Meilhac, Sigolène M

“…How left-right patterning drives asymmetric morphogenesis is unclear. Here, we have quantified shape changes during mouse heart looping, from 3D…”
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Asymmetric Fate of the Posterior Part of the Second Heart Field Results in Unexpected Left/Right Contributions to Both Poles of the Heart by Domínguez, Jorge N, Meilhac, Sigolène M, Bland, Yvette S, Buckingham, Margaret E, Brown, Nigel A

“…RATIONALE:The second heart field (SHF) contains progenitors of all heart chambers, excluding the left ventricle. The SHF is patterned, and the anterior region…”
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Identification of atrial‐enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation by García‐Padilla, Carlos, Domínguez, Jorge N., Lodde, Valeria, Munk, Rachel, Abdelmohsen, Kotb, Gorospe, Myriam, Jiménez‐Sábado, Veronica, Ginel, Antonino, Hove‐Madsen, Leif, Aránega, Amelia E., Franco, Diego

“…Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in humans. Genetic and genomic analyses have recently demonstrated that the homeobox…”
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Cre recombinase microinjection for single-cell tracing and localised gene targeting by Sendra, Miquel, de Dios Hourcade, Juan, Temiño, Susana, Sarabia, Antonio J, Ocaña, Oscar H, Domínguez, Jorge N, Torres, Miguel

“…Tracing and manipulating cells in embryos are essential to understand development. Lipophilic dye microinjections, viral transfection and iontophoresis have…”
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The sinus venosus progenitors separate and diversify from the first and second heart fields early in development by Mommersteeg, Mathilda T.M., Domínguez, Jorge N., Wiese, Cornelia, Norden, Julia, de Gier-de Vries, Corrie, Burch, John B.E., Kispert, Andreas, Brown, Nigel A., Moorman, Antoon F.M., Christoffels, Vincent M.

“…Aims During development, the heart tube grows by differentiation of Isl1+/Nkx2-5+ progenitors to the arterial and venous pole and dorsal mesocardium. However,…”
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Regulation of Epicardial Cell Fate during Cardiac Development and Disease: An Overview by Sanchez-Fernandez, Cristina, Rodriguez-Outeiriño, Lara, Matias-Valiente, Lidia, Ramirez de Acuña, Felicitas, Hernandez-Torres, Francisco, Lozano-Velasco, Estefania, Dominguez, Jorge N, Franco, Diego, Aranega, Amelia Eva

“…The epicardium is the outermost cell layer in the vertebrate heart that originates during development from mesothelial precursors located in the proepicardium…”
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c-Jun kinase mediates expression of VEGF induced at transcriptional level by Rac1 and Cdc42Hs but not by RhoA by Saníger, M. Luisa, Oya, Ricardo, Macías, David, Domínguez, Jorge N., Aránega, Amelia, Luque, Francisco

“…Tumour angiogenesis is mediated by increased levels of vascular endothelial growth factor (VEGF). We have studied the mechanism by which endogenous activation…”
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Pitx2 Differentially Regulates the Distinct Phases of Myogenic Program and Delineates Satellite Cell Lineages During Muscle Development by Ramírez de Acuña, Felícitas, Hernandez-Torres, Francisco, Rodriguez-Outeiriño, Lara, Dominguez, Jorge N., Matias-Valiente, Lidia, Sanchez-Fernandez, Cristina, Franco, Diego, Aranega, Amelia E.

“…The knowledge of the molecular mechanisms that regulate embryonic myogenesis from early myogenic progenitors to myoblasts, as well as the emergence of adult…”
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Arid3b is essential for second heart field cell deployment and heart patterning by Uribe, Verónica, Badía-Careaga, Claudio, Casanova, Jesús C, Domínguez, Jorge N, de la Pompa, José Luis, Sanz-Ezquerro, Juan José

“…Arid3b, a member of the conserved ARID family of transcription factors, is essential for mouse embryonic development but its precise roles are poorly…”
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Cardiac Development: A Glimpse on Its Translational Contributions by Franco, Diego, Garcia-Padilla, Carlos, Dominguez, Jorge N., Lozano-Velasco, Estefania, Aranega, Amelia

“…Cardiac development is a complex developmental process that is initiated soon after gastrulation, as two sets of precardiac mesodermal precursors are…”
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