Search Results - "Dolui, Sandip"
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Hydrogen bonding plays a significant role in the binding of coomassie brilliant blue-R to hemoglobin: FT-IR, fluorescence and molecular dynamics studies
Published in Physical chemistry chemical physics : PCCP (01-01-2015)“…An analog of coomassie brilliant blue-R (CBB-R) was recently found to act as an antagonist to ATP-sensitive purinergic receptors (P2X7R) and has potential to…”
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Dabrafenib, idelalisib and nintedanib act as significant allosteric modulator for dengue NS3 protease
Published in PloS one (10-09-2021)“…Dengue virus (DENV) encodes a unique protease (NS3/NS2B) essential for its maturation and infectivity and, it has become a key target for anti-viral drug…”
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Structural Insight of Amyloidogenic Intermediates of Human Insulin
Published in ACS omega (28-02-2018)“…Engaging Raman spectroscopy as a primary tool, we investigated the early events of insulin fibrilization and determined the structural content present in…”
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Raman Spectroscopic Insights of Phase-Separated Insulin Aggregates
Published in ACS Physical Chemistry Au (22-05-2024)“…Phase-separated protein accumulation through the formation of several aggregate species is linked to the pathology of several human disorders and diseases. Our…”
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Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity
Published in Frontiers in chemistry (26-05-2023)“…Parkinson's disease is an age-related neurological disorder, and the pathology of the disease is linked to different types of aggregates of α-synuclein or…”
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Envisaging the Structural Elevation in the Early Event of Oligomerization of Disordered Amyloid β Peptide
Published in ACS omega (31-08-2017)“…In Alzheimer’s disease (AD), amyloid β (Aβ) protein plays a detrimental role in neuronal injury and death. Recent in vitro and in vivo studies suggest that…”
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Order, Disorder, and Reorder State of Lysozyme: Aggregation Mechanism by Raman Spectroscopy
Published in The journal of physical chemistry. B (09-01-2020)“…Lysozyme, like many other well-folded globular proteins, under stressful conditions produces nanoscale oligomer assembly and amyloid-like fibrillar aggregates…”
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Structure specific neuro-toxicity of α-synuclein oligomer
Published in International journal of biological macromolecules (31-12-2023)“…Parkinson's disease (PD) is linked to α-synuclein (aS) aggregation and deposition of amyloid in the substantia nigra region of the brain tissues. In the…”
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Astrakurkurone, a sesquiterpenoid from wild edible mushroom, targets liver cancer cells by modulating Bcl‐2 family proteins
Published in IUBMB life (01-07-2019)“…Induction of apoptosis is the target of choice for modern chemotherapeutic treatment of cancer, where lack of potent “target‐specific” drugs has led to…”
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Coomassie brilliant blue G-250 acts as a potential chemical chaperone to stabilize therapeutic insulin
Published in Chemical communications (Cambridge, England) (27-06-2023)“…Our studies show Coomassie Brilliant Blue G-250 as a promising chemical chaperone that stabilises the α-helical native human insulin conformers, disrupting…”
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Impact of porous nanomaterials on inhibiting protein aggregation behaviour
Published in RSC advances (15-01-2021)“…Aggregation of intrinsically disordered as well as the ordered proteins under certain premises or physiological conditions leads to pathological disorder. Here…”
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Unveiling the binding interaction of zinc (II) complexes of homologous Schiff‐base ligands on the surface of BSA protein: A combined experimental and theoretical approach
Published in Applied organometallic chemistry (01-04-2020)“…Four new zinc (II) complexes [Zn (HL1H)Br2] (1), [Zn (HL1H)Cl2] (2), [Zn2(HL2)Br3] (3), and [Zn (HL2)Cl] (4) have been synthesized by adopting template…”
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Formulation and antitumorigenic activities of nanoencapsulated nifetepimine: A promising approach in treating triple negative breast carcinoma
Published in Nanomedicine (01-10-2016)“…Abstract Triple negative breast cancer (TNBC) is one of the most common invasive malignancies among women, associated with poor prognosis. Standard…”
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