Microencapsulation of Lactobacillus plantarum (mtcc 5422) by spray-freeze-drying method and evaluation of survival in simulated gastrointestinal conditions

Spray-drying (SD) and freeze-drying (FD) are widely used methods for microencapsulation of heat-sensitive materials like probiotics for long-term preservation and transport. Spray-freeze-drying (SFD) is relatively a new technique that involves spraying a solution into a cold medium and removal of so...

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Bibliographic Details
Published in:	Journal of microencapsulation Vol. 28; no. 6; pp. 568 - 574
Main Authors:	Dolly, Priyanka, Anishaparvin, A., Joseph, G. S., Anandharamakrishnan, C.
Format:	Journal Article
Language:	English
Published:	Colchester Informa UK, Ltd 01-09-2011 Taylor & Francis Informa
Subjects:	Biological and medical sciences core-to-wall ratio Drug Compounding - methods Freeze Drying - methods freeze-drying Gastrointestinal Tract - metabolism General pharmacology Humans Lactobacillus plantarum - cytology Medical sciences Microbial Viability microencapsulation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments spray-drying spray-freeze-drying Stomach Evaluation spray-freeze-drying Freeze drying Lactobacillus plantarum Pharmaceutical technology Gut Spray drying Gastrointestinal Survival core-to-wall ratio Bacteria Lactobacillaceae freeze-drying Microencapsulation spray-drying
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Summary:	Spray-drying (SD) and freeze-drying (FD) are widely used methods for microencapsulation of heat-sensitive materials like probiotics for long-term preservation and transport. Spray-freeze-drying (SFD) is relatively a new technique that involves spraying a solution into a cold medium and removal of solvent (water) by conventional vacuum FD method. In this study, the SFD microencapsulated Lactobacillus plantarum powder (1:1 and 1:1.5 core-to-wall ratios of whey protein) is compared with the microencapsulated powders produced by FD and SD methods. The SFD and FD processed microencapsulated powder show 20% higher cell viability than the SD samples. In simulated gastrointestinal conditions, the SFD and FD cells show up to 4 h better tolerance than SD samples and unencapsulated cells in acidic and pepsin condition. The morphology of SFD samples shows particles almost in spherical shape with numerous fine pores, which in turn results in good rehydration behaviour of the powdered product.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0265-2048 1464-5246
DOI:	10.3109/02652048.2011.599435