CT perfusion and noncontrast CT in acute ischemic stroke diagnosing--is there influence on early thrombolytic therapy outcome?

The objective of this study was to compare noncontrast computed tomography (NCCT) and computed tomography perfusion (CTP) in early diagnosis of acute ischemic stroke and to define influence of these diagnostic procedures on early outcome of thrombolytic therapy (TLTH). The study included 45 patients...

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Bibliographic Details
Published in:	Collegium antropologicum Vol. 34; no. 4; p. 1391
Main Authors:	Janković, Stipan, Pavicić Ivelja, Mirela, Kolić, Kresimir, Buca, Ante, Dolić, Kremimir, Lovrić Kojundzić, Sanja, Caljkusić, Kresimir, Bilić, Ivica, Capkun, Vesna
Format:	Journal Article
Language:	English
Published:	Croatia 01-12-2010
Subjects:	Adolescent Adult Aged Aged, 80 and over Brain Ischemia - diagnostic imaging Brain Ischemia - drug therapy Female Humans Male Middle Aged Stroke - diagnostic imaging Stroke - drug therapy Thrombolytic Therapy Tomography, X-Ray Computed
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Summary:	The objective of this study was to compare noncontrast computed tomography (NCCT) and computed tomography perfusion (CTP) in early diagnosis of acute ischemic stroke and to define influence of these diagnostic procedures on early outcome of thrombolytic therapy (TLTH). The study included 45 patients, 35 patients submitted to NCCT and CTP and 10 patients who underwent only NCCT, before CTP was introduced. Based on the National Institute of Health Stroke Scale (NIHSS) score we compared early outcome of patients who received TLTH after NCCT only (group 1) with the early outcome of patients who received TLTH following NCCT and CTP (group 2). Statistically significant difference was found in acute stroke diagnosing between CTP and NCCT (p = 0.002). There were no statistically significant differences in TLTH early outcome between group 1 and group 2. In conclusion, CTP should be done regulary in patients presenting with acute ischemic stroke symptoms. More research needs to be done in defining exact influence of CTP implementation on the TLTH outcome.
ISSN:	0350-6134