Search Results - "Dolghih, Elena"

A structure-based model for predicting serum albumin binding by Lexa, Katrina W, Dolghih, Elena, Jacobson, Matthew P

“…One of the many factors involved in determining the distribution and metabolism of a compound is the strength of its binding to human serum albumin. While…”
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Predicting binding to p-glycoprotein by flexible receptor docking by Dolghih, Elena, Bryant, Clifford, Renslo, Adam R, Jacobson, Matthew P

“…P-glycoprotein (P-gp) is an ATP-dependent transport protein that is selectively expressed at entry points of xenobiotics where, acting as an efflux pump, it…”
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Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior by Hindle, Samantha J., Munji, Roeben N., Dolghih, Elena, Gaskins, Garrett, Orng, Souvinh, Ishimoto, Hiroshi, Soung, Allison, DeSalvo, Michael, Kitamoto, Toshihiro, Keiser, Michael J., Jacobson, Matthew P., Daneman, Richard, Bainton, Roland J.

“…Central nervous system (CNS) chemical protection depends upon discrete control of small-molecule access by the blood-brain barrier (BBB). Curiously, some drugs…”
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Molecular and functional characterization of a juvenile hormone acid methyltransferase expressed in the corpora allata of mosquitoes by Mayoral, Jaime G., Nouzova, Marcela, Yoshiyama, Michiyo, Shinoda, Tetsuro, Hernandez-Martinez, Salvador, Dolghih, Elena, Turjanski, Adrian G., Roitberg, Adrian E., Priestap, Horacio, Perez, Mario, Mackenzie, Lucy, Li, Yiping, Noriega, Fernando G.

“…A juvenile hormone acid methyltransferase (JHAMT) was isolated as an abundant EST in a library of the corpora allata of the adult female mosquito Aedes…”
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Enzymatic Assimilation of Cyanide via Pterin-Dependent Oxygenolytic Cleavage to Ammonia and Formate in Pseudomonas fluorescens NCIMB 11764 by FERNANDEZ, Ruby F, DOLGHIH, Elena, KUNZ, Daniel A

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Predicting Efflux Ratios and Blood-Brain Barrier Penetration from Chemical Structure: Combining Passive Permeability with Active Efflux by P‑Glycoprotein by Dolghih, Elena, Jacobson, Matthew P

“…In order to reach their pharmacologic targets, successful central nervous system (CNS) drug candidates have to cross a complex protective barrier separating…”
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Fluorescence resonance energy transfer in dye-labeled DNA by Dolghih, Elena, Roitberg, Adrian E., Krause, Jeffrey L.

“…We present the results of molecular modeling of dye-labeled, double-stranded DNA. The structural information obtained from the simulations are used as input to…”
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Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice by Lu, Duo, Giles, Kurt, Li, Zhe, Rao, Satish, Dolghih, Elena, Gever, Joel R, Geva, Michal, Elepano, Manuel L, Oehler, Abby, Bryant, Clifford, Renslo, Adam R, Jacobson, Matthew P, Dearmond, Stephen J, Silber, B Michael, Prusiner, Stanley B

“…The only small-molecule compound demonstrated to substantially extend survival in prion-infected mice is a biaryl hydrazone termed "Compd B"…”
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Predicting Binding to P-Glycoprotein by Flexible Receptor Docking: e1002083 by Dolghih, Elena, Bryant, Clifford, Renslo, Adam R, Jacobson, Matthew P

“…P-glycoprotein (P-gp) is an ATP-dependent transport protein that is selectively expressed at entry points of xenobiotics where, acting as an efflux pump, it…”
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Theoretical Studies of Short Polyproline Systems: Recalibration of a Molecular Ruler by Dolghih, Elena, Ortiz, Wilfredo, Kim, Seonah, Krueger, Brent P, Krause, Jeffrey L, Roitberg, Adrian E

“…FRET experiments enable studies of the chemical and physical properties of individual molecules, which has long been a dream of chemists. However, these modern…”
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2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease by Li, Zhe, Silber, B. Michael, Rao, Satish, Gever, Joel R., Bryant, Clifford, Gallardo-Godoy, Alejandra, Dolghih, Elena, Widjaja, Kartika, Elepano, Manuel, Jacobson, Matthew P., Prusiner, Stanley B., Renslo, Adam R.

“…Recently, we described the aminothiazole lead (4‐biphenyl‐4‐ylthiazol‐2‐yl)‐(6‐methylpyridin‐2‐yl)‐amine (1), which exhibits many desirable properties,…”
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Bacterial cyanide assimilation: Pterin cofactor and enzymatic requirements for substrate oxidation by Dolghih, Elena

“…Utilization of cyanide as the sole nitrogen source by Pseudomonas fluorescens NCIMB 11764 (Pf11764) occurs via oxidative conversion to carbon dioxide and…”
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