Search Results - "Dolganov, Gregory M."

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids by Woodruff, Prescott G, Boushey, Homer A, Dolganov, Gregory M, Barker, Chris S, Yang, Yee Hwa, Donnelly, Samantha, Ellwanger, Almut, Sidhu, Sukhvinder S, Dao-Pick, Trang P, Pantoja, Carlos, Erle, David J, Yamamoto, Keith R, Fahy, John V

“…Airway inflammation and epithelial remodeling are two key features of asthma. IL-13 and other cytokines produced during T helper type 2 cell-driven allergic…”
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In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects by Lopez-Souza, Nilceia, MD, PhD, Favoreto, Silvio, DDS, PhD, Wong, Hofer, BS, Ward, Theresa, RN, Yagi, Shigeo, PhD, Schnurr, David, MD, Finkbeiner, Walter E., MD, PhD, Dolganov, Gregory M., PhD, Widdicombe, Jonathan H., PhD, Boushey, Homer A., MD, Avila, Pedro C., MD

“…Background Human rhinoviruses (HRVs) characteristically cause upper respiratory tract infection, but they also infect the lower airways, causing acute…”
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Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics by Knudsen, Niels Peter H., Nørskov-Lauritsen, Sara, Dolganov, Gregory M., Schoolnik, Gary K., Lindenstrøm, Thomas, Andersen, Peter, Agger, Else Marie, Aagaard, Claus

“…A central goal in vaccine research is the identification of relevant antigens. The Mycobacterium tuberculosis chromosome encodes 23 early secretory antigenic…”
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Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma by Erle, David J, Kuperman, Douglas A, Huang, Xiaozhu, Koth, Laura L, Chang, Grace H, Dolganov, Gregory M, Zhu, Zhou, Elias, Jack A, Sheppard, Dean

“…Asthma is an increasingly common disease that remains poorly understood and difficult to manage. This disease is characterized by airway hyperreactivity (AHR,…”
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Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction by Innes, Anh L, Woodruff, Prescott G, Ferrando, Ronald E, Donnelly, Samantha, Dolganov, Gregory M, Lazarus, Stephen C, Fahy, John V

“…Habitual cigarette smoking is associated with chronic mucus hypersecretion, but the relationship between mucus abnormalities and airflow obstruction in smokers…”
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Hyperplasia of Smooth Muscle in Mild to Moderate Asthma without Changes in Cell Size or Gene Expression by Woodruff, Prescott G, Dolganov, Gregory M, Ferrando, Ronald E, Donnelly, Samantha, Hays, Steven R, Solberg, Owen D, Carter, Roderick, Wong, Hofer H, Cadbury, Peggy S, Fahy, John V

“…Bronchial hyperresponsiveness in mild to moderate asthma may result from airway smooth muscle cell proliferation or acquisition of a hypercontractile…”
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A Distinctive Alveolar Macrophage Activation State Induced by Cigarette Smoking by Woodruff, Prescott G, Koth, Laura L, Yang, Yee Hwa, Rodriguez, Madeleine W, Favoreto, Silvio, Dolganov, Gregory M, Paquet, Agnes C, Erle, David J

“…Macrophages are believed to play a central role in emphysema based largely on data from mouse models. However, the relevance of these models to smoking-related…”
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Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells by Liu, Jian, Sukhova, Galina K., Yang, Jin-Tian, Sun, Jiusong, Ma, Likun, Ren, An, Xu, Wei-Hua, Fu, Huanxiang, Dolganov, Gregory M., Hu, Chengcheng, Libby, Peter, Shi, Guo-Ping

“…The cysteine protease cathepsin L is one of the most potent mammalian elastases and collagenases, widely expressed at basal levels in most tested tissues and…”
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The Epithelial Anion Transporter Pendrin Is Induced by Allergy and Rhinovirus Infection, Regulates Airway Surface Liquid, and Increases Airway Reactivity and Inflammation in an Asthma Model by Nakagami, Yasuhiro, Favoreto, Silvio, Jr, Zhen, Guohua, Park, Sung-Woo, Nguyenvu, Louis T, Kuperman, Douglas A, Dolganov, Gregory M, Huang, Xiaozhu, Boushey, Homer A, Avila, Pedro C, Erle, David J

“…Asthma exacerbations can be triggered by viral infections or allergens. The Th2 cytokines IL-13 and IL-4 are produced during allergic responses and cause…”
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Dissecting asthma using focused transgenic modeling and functional genomics by Kuperman, Douglas A., Lewis, Christina C., Woodruff, Prescott G., Rodriguez, Madeleine W., Yang, Yee Hwa, Dolganov, Gregory M., Fahy, John V., Erle, David J.

“…Asthma functional genomics studies are challenging because it is difficult to relate gene expression changes to specific disease mechanisms or pathophysiologic…”
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CXCR4 expression reflects tumor progression and regulates motility of bladder cancer cells by Retz, Margitta M., Sidhu, Sukhvinder S., Blaveri, Ekaterina, Kerr, Sheena C., Dolganov, Gregory M., Lehmann, Jan, Carroll, Peter, Simko, Jeff, Waldman, Frederic M., Basbaum, Carol

“…Transitional cell carcinoma of the urinary bladder remains life threatening due to the high occurrence of metastases. Emerging evidence suggests that…”
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c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases by Edwards, Samuel T, Cruz, Anthony C, Donnelly, Samantha, Dazin, Paul F, Schulman, Edward S, Jones, Kirk D, Wolters, Paul J, Hoopes, Charles, Dolganov, Gregory M, Fang, Kenneth C

“…Diverse interstitial lung diseases (ILD) demonstrate mesenchymal infiltration by an abundance of activated mast cells whose role in parenchymal fibrogenesis…”
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Increased DNA microarray hybridization specificity using sscDNA targets by Barker, Christopher S, Griffin, Chandi, Dolganov, Gregory M, Hanspers, Kristina, Yang, Jean Yee Hwa, Erle, David J

“…The most widely used amplification method for microarray analysis of gene expression uses T7 RNA polymerase-driven in vitro transcription (IVT) to produce…”
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Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis by Walter, Nicholas D., Dolganov, Gregory M., Garcia, Benjamin J., Worodria, William, Andama, Alfred, Musisi, Emmanuel, Ayakaka, Irene, Van, Tran T., Voskuil, Martin I., de Jong, Bouke C., Davidson, Rebecca M., Fingerlin, Tasha E., Kechris, Katerina, Palmer, Claire, Nahid, Payam, Daley, Charles L., Geraci, Mark, Huang, Laurence, Cattamanchi, Adithya, Strong, Michael, Schoolnik, Gary K., Davis, John Lucian

“…Background. Treatment initiation rapidly kills most drug-susceptible Mycobacterium tuberculosis, but a bacterial subpopulation tolerates prolonged drug…”
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Comprehensive insights into transcriptional adaptation of intracellular mycobacteria by microbe-enriched dual RNA sequencing by Rienksma, Rienk A, Suarez-Diez, Maria, Mollenkopf, Hans-Joachim, Dolganov, Gregory M, Dorhoi, Anca, Schoolnik, Gary K, Martins Dos Santos, Vitor Ap, Kaufmann, Stefan He, Schaap, Peter J, Gengenbacher, Martin

“…The human pathogen Mycobacterium tuberculosis has the capacity to escape eradication by professional phagocytes. During infection, M. tuberculosis resists the…”
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Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis by Marmai, Cecilia, Sutherland, Rachel E, Kim, Kevin K, Dolganov, Gregory M, Fang, Xiaohui, Kim, Sophia S, Jiang, Shuwei, Golden, Jeffery A, Hoopes, Charles W, Matthay, Michael A, Chapman, Harold A, Wolters, Paul J

“…Prior work has shown that transforming growth factor-β (TGF-β) can mediate transition of alveolar type II cells into mesenchymal cells in mice. Evidence this…”
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Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program by Voskuil, Martin I, Schnappinger, Dirk, Visconti, Kevin C, Harrell, Maria I, Dolganov, Gregory M, Sherman, David R, Schoolnik, Gary K

“…An estimated two billion persons are latently infected with Mycobacterium tuberculosis. The host factors that initiate and maintain this latent state and the…”
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Adaptation of "Mycobacterium tuberculosis" to Impaired Host Immunity in HIV-Infected Patients by Walter, Nicholas D., de Jong, Bouke C., Garcia, Benjamin J., Dolganov, Gregory M., Worodria, William, Byanyima, Patrick, Musisi, Emmanuel, Huang, Laurence, Chan, Edward D., Van, Tran T., Antonio, Martin, Ayorinde, Abigail, Kato-Maeda, Midori, Nahid, Payam, Leung, Ann M., Yen, Andrew, Fingerlin, Tasha E., Kechris, Katerina, Strong, Michael, Voskuil, Martin I., Davis, J. Lucian, Schoolnik, Gary K.

“…Background. It is unknown whether immunosuppression influences the physiologic state of Mycobacterium tuberculosis in vivo. We evaluated the impact of host…”
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Sputum is a surrogate for bronchoalveolar lavage for monitoring Mycobacterium tuberculosis transcriptional profiles in TB patients by Garcia, Benjamin J, Loxton, Andre G, Dolganov, Gregory M, Van, Tran T, Davis, J. Lucian, de Jong, Bouke C, Voskuil, Martin I, Leach, Sonia M, Schoolnik, Gary K, Walzl, Gerhard, Strong, Michael, Walter, Nicholas D

“…Summary Pathogen-targeted transcriptional profiling in human sputum may elucidate the physiologic state of Mycobacterium tuberculosis ( M.tb ) during infection…”
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Immune Complex-Dependent Remodeling of the Airway Vasculature in Response to a Chronic Bacterial Infection by Aurora, Arin B, Baluk, Peter, Zhang, DongJi, Sidhu, Sukhvinder S, Dolganov, Gregory M, Basbaum, Carol, McDonald, Donald M, Killeen, Nigel

“…Chronic inflammation in the airways is associated with dramatic architectural changes in the walls of the airways and in the vasculature they contain. In this…”
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