Search Results - "Dolenc, Iztok"

Glucosamine prevents polarization of cytotoxic granules in NK-92 cells by disturbing FOXO1/ERK/paxillin phosphorylation by Božič, Janja, Stoka, Veronika, Dolenc, Iztok

“…Glucosamine (GlcN) is a naturally occurring derivative of glucose and an over-the-counter food additive. However, the mechanism underlying GlcN action on cells…”
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Feedback Regulation of Cathepsin C by the Propeptide Dipeptides of Granzymes A and B by Božič, Janja, Dolenc, Iztok

“…Granzymes A and B are activated by proteolytic removal of their N-terminal dipeptides by cathepsin C (dipeptidyl-peptidase I). However, the possible…”
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Expression, purification and auto-activation of cathepsin E from insect cells by Železnik, Tajana Z, Puizdar, Vida, Dolenc, Iztok

“…Cathepsin E is an aspartic protease that belongs to the pepsin family. This protease is similar to cathepsin D but differs in its tissue distribution and cell…”
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Soft roll linings - better conduits: First press of the PS 2, paper machine, Belišće, Croatia by Dolenc Iztok

“…Paper with demanding technical properties is formed in the press of the paper machine when the paper pulp is passed between the rolls. In order to form paper…”
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Oligomeric Structure and Substrate Induced Inhibition of Human Cathepsin C (∗) by Dolenc, Iztok, Turk, Boris, Pungercic, Galina, Ritonja, Anka, Turk, Vito

“…Cathepsin C has been purified from human kidney by a modified procedure. Human cathepsin C was isolated as pure protein with a pI close to 6.0. The enzyme was…”
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Molecular cloning and sequence analysis of human preprocathepsin C by Pariš, Alenka, Štrukelj, Borut, Pungerčar, Jože, Renko, Metka, Dolenc, Iztok, Turk, Vito

“…A cDNA clone (C1) coding for human preprocathepsin C was isolated from a human ileum cDNA library using a rat kidney-derived RT-PCR probe and its complete…”
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Human cathepsin X/Z is a biologically active homodimer by Dolenc, Iztok, Štefe, Ivica, Turk, Dušan, Taler-Verčič, Ajda, Turk, Boris, Turk, Vito, Stoka, Veronika

“…Human cathepsin X belongs to the cathepsin family of 11 lysosomal cysteine proteases. We expressed recombinant procathepsin X in Pichia pastoris in vitro and…”
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Tumor Necrosis Factor‐α Induced Apoptosis in U937 Cells Promotes Cathepsin D‐Independent Stefin B Degradation by Bidovec, Katja, Božič, Janja, Dolenc, Iztok, Turk, Boris, Turk, Vito, Stoka, Veronika

“…ABSTRACT Lysosomal cathepsins were previously found to be involved in tumor necrosis factor‐α (TNFα)‐induced apoptosis. However, there are opposing views…”
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Characteristics, Structure, and Biological Role of Stefins (type-1 cystatins) of Human, Mammal, and Parasite Origin by Vito Turk, Dušan Turk, Iztok Dolenc, Veronika Stoka

“…The majority of lysosomal cysteine cathepsins are ubiquitously expressed enzymes. However, some of them differ in their specific cell or tissue distribution…”
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Aspartic cathepsin D degrades the cytosolic cysteine cathepsin inhibitor stefin B in the cells by Železnik, Tajana Zajc, Kadin, Andrey, Turk, Vito, Dolenc, Iztok

“…Stefin B is the major general cytosolic protein inhibitor of cysteine cathepsins. Its main function is to protect the organism against the activity of…”
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Menadione‐induced apoptosis in U937 cells involves Bid cleavage and stefin B degradation by Božič, Janja, Bidovec, Katja, Vizovišek, Matej, Dolenc, Iztok, Stoka, Veronika

“…Earlier studies showed that the oxidant menadione (MD) induces apoptosis in certain cells and also has anticancer effects. Most of these studies emphasized the…”
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Identification of bovine stefin A, a novel protein inhibitor of cysteine proteinases by Turk, Boris, Ritonja, Anka, Björk, Ingemar, Stoka, Veronika, Dolenc, Iztok, Turk, Vito

“…For the first time, three different stefins, A, B and C, have been isolated from a single species. The complete amino acid sequence of bovine stefin A was…”
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Acidic pH as a physiological regulator of human cathepsin L activity by Turk, Boris, Dolenc, Iztok, Lenarčič, Brigita, Križaj, Igor, Turk, Vito, Bieth, Joseph G., Björk, Ingemar

“…Human cysteine protease cathepsin L was inactivated at acid pH by a first‐order process. The inactivation rate decreased with increasing concentrations of a…”
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Characteristics, Structure, and Biological Role of Stefins (Type-1 Cystatins) of Human by Turk, Vito, Turk, Dušan, Dolenc, Iztok, Stoka, Veronika

“…The majority of lysosomal cysteine cathepsins are ubiquitously expressed enzymes. However, some of them differ in their specific cell or tissue distribution…”
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Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and/or endogenous protein inhibitors, cystatins by Turk, B, Bieth, J G, Björk, I, Dolenc, I, Turk, D, Cimerman, N, Kos, J, Colic, A, Stoka, V, Turk, V

“…The kinetics of pH-induced inactivation of human cathepsins B and L was studied by conventional and stopped-flow methods. The inactivation of both enzymes was…”
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Cathepsin C and plasma glutamate carboxypeptidase secreted from Fischer rat thyroid cells liberate thyroxin from the N-terminus of thyroglobulin by Suban, Dejan, Zajc, Tajana, Renko, Miha, Turk, Boris, Turk, Vito, Dolenc, Iztok

“…The release of a thyroid hormone from thyroglobulin is controlled by a complex regulatory system. We focused on the extracellular action of two lysosomal…”
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Baculoviral expression and characterization of human recombinant PGCP in the form of an active mature dimer and an inactive precursor protein by Zajc, Tajana, Suban, Dejan, Rajković, Jelena, Dolenc, Iztok

“…The human-blood plasma glutamate carboxypeptidase (PGCP) is a proteinase that acts on the unsubstituted N- and C-termini of dipeptides. It has been suggested…”
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N-terminally truncated forms of human cathepsin F accumulate in aggresome-like inclusions by Jerič, Barbara, Dolenc, Iztok, Mihelič, Marko, Klarić, Martina, Zavašnik-Bergant, Tina, Gunčar, Gregor, Turk, Boris, Turk, Vito, Stoka, Veronika

“…The contribution of individual cysteine cathepsins as positive mediators of programmed cell death is dependent on several factors, such as the type of stimuli,…”
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Presence of the propeptide on recombinant lysosomal dipeptidase controls both activation and dimerization by Dolenc, Iztok, Pain, Roger, Turk, Vito

“…Lysosomal dipeptidase catalyzes the hydrolysis of dipeptides with unsubstituted terminals. It is a homodimer and binds zinc. Dimerization is an important issue…”
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Crystal Structure of Stefin A in Complex with Cathepsin H: N-terminal Residues of Inhibitors can Adapt to the Active Sites of Endo- and Exopeptidases by Jenko, Saša, Dolenc, Iztok, Gunčar, Gregor, Doberšek, Andreja, Podobnik, Marjetka, Turk, Dušan

“…Binding of cystatin-type inhibitors to papain-like exopeptidases cannot be explained by the stefin B–papain complex. The crystal structure of human stefin A…”
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