Formulation development and evaluation of orodispersible tablet of Azelnidipine by factorial design and its comparison with the marketed formulation
The aim of the present investigation was to prepare an orodispersible tablet of Azelnidipine using superdisintegrant agents like croscarmellose sodium by direct compression method. These formulated tablets were evaluated for drug content, weight variation, friability, hardness, solubility study also...
Saved in:
| Published in: | Particulate science and technology Vol. 41; no. 7; pp. 1053 - 1061 |
|---|---|
| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Philadelphia
Taylor & Francis
03-10-2023
Taylor & Francis Ltd |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The aim of the present investigation was to prepare an orodispersible tablet of Azelnidipine using superdisintegrant agents like croscarmellose sodium by direct compression method. These formulated tablets were evaluated for drug content, weight variation, friability, hardness, solubility study also, and drug excipient compatibility study. Based on data obtained from pre-compression and post-compression evaluation of batches as well as the factorial design model study f7 batch was selected as the optimized batch. Based on the result obtained from the dissolution profile study it was concluded that the formula responsible for Azelnidipine tablets gives the fastest disintegration as well as absorption of the drug as compared to the conventional marketed tablet dosage form. |
|---|---|
| ISSN: | 0272-6351 1548-0046 |
| DOI: | 10.1080/02726351.2023.2173109 |