Search Results - "Dokter, Wim"

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985 by Elgersma, Ronald C, Coumans, Ruud G. E, Huijbregts, Tijl, Menge, Wiro M. P. B, Joosten, John A. F, Spijker, Henri J, de Groot, Franciscus M. H, van der Lee, Miranda M. C, Ubink, Ruud, van den Dobbelsteen, Diels J, Egging, David F, Dokter, Wim H. A, Verheijden, Gijs F. M, Lemmens, Jacques M, Timmers, C. Marco, Beusker, Patrick H

“…Antibody–drug conjugates (ADCs) that are currently on the market or in clinical trials are predominantly based on two drug classes: auristatins and…”
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The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers by van der Lee, Miranda M C, Groothuis, Patrick G, Ubink, Ruud, van der Vleuten, Monique A J, van Achterberg, Tanja A, Loosveld, Eline M, Damming, Désirée, Jacobs, Daniëlle C H, Rouwette, Myrthe, Egging, David F, van den Dobbelsteen, Diels, Beusker, Patrick H, Goedings, Peter, Verheijden, Gijs F M, Lemmens, Jacques M, Timmers, Marco, Dokter, Wim H A

“…SYD985 is a HER2-targeting antibody-drug conjugate (ADC) based on trastuzumab and vc-seco-DUBA, a cleavable linker-duocarmycin payload. To evaluate the…”
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A Platform for the Generation of Site-Specific Antibody–Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines by Coumans, Ruud G. E, Ariaans, Gerry J. A, Spijker, Henri J, Renart Verkerk, Pascal, Beusker, Patrick H, Kokke, Bas P. A, Schouten, Jan, Blomenröhr, Marion, van der Lee, Miranda M. C, Groothuis, Patrick G, Ubink, Ruud, Dokter, Wim H. A, Timmers, C. Marco

“…Engineering cysteines at specific sites in antibodies to create well-defined ADCs for the treatment of cancer is a promising approach to increase the…”
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Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody-Drug Conjugates in Breast Cancer by Duro-Sánchez, Santiago, Nadal-Serrano, Mercedes, Lalinde-Gutiérrez, Marta, Arenas, Enrique Javier, Bernadó Morales, Cristina, Morancho, Beatriz, Escorihuela, Marta, Pérez-Ramos, Sandra, Escrivá-de-Romaní, Santiago, Gandullo-Sánchez, Lucía, Pandiella, Atanasio, Esteve-Codina, Anna, Rodilla, Verónica, Dijcks, Fred A, Dokter, Wim H A, Cortés, Javier, Saura, Cristina, Arribas, Joaquín

“…Antibody-drug conjugates (ADC) are antineoplastic agents recently introduced into the antitumor arsenal. T-DM1, a trastuzumab-based ADC that relies on…”
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SYD985, a Novel Duocarmycin-Based HER2-Targeting Antibody-Drug Conjugate, Shows Antitumor Activity in Uterine Serous Carcinoma with HER2/Neu Expression by Black, Jonathan, Menderes, Gulden, Bellone, Stefania, Schwab, Carlton L, Bonazzoli, Elena, Ferrari, Francesca, Predolini, Federica, De Haydu, Christopher, Cocco, Emiliano, Buza, Natalia, Hui, Pei, Wong, Serena, Lopez, Salvatore, Ratner, Elena, Silasi, Dan-Arin, Azodi, Masoud, Litkouhi, Babak, Schwartz, Peter E, Goedings, Peter, Beusker, Patrick H, van der Lee, Miranda M C, Timmers, C Marco, Dokter, Wim H A, Santin, Alessandro D

“…Uterine serous carcinoma (USC) is an aggressive form of endometrial cancer. Up to 35% of USC may overexpress the HER2/neu oncogene at strong (i.e., 3+) levels…”
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Acute and 2-week exposure to prednisolone impair different aspects of β-cell function in healthy men by van Raalte, Daniël H, Nofrate, Valentina, Bunck, Mathijs C, van Iersel, Thijs, Elassaiss Schaap, Jeroen, Nässander, Ulla K, Heine, Robert J, Mari, Andrea, Dokter, Wim H A, Diamant, Michaela

“…ObjectiveGlucocorticoids (GCs), such as prednisolone, are associated with adverse metabolic effects, including glucose intolerance and diabetes. In contrast to…”
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The Second Generation Antibody-Drug Conjugate SYD985 Overcomes Resistances to T-DM1 by Nadal-Serrano, Mercedes, Morancho, Beatriz, Escrivá-de-Romaní, Santiago, Morales, Cristina Bernadó, Luque, Antonio, Escorihuela, Marta, Espinosa Bravo, Martín, Peg, Vicente, Dijcks, Fred A, Dokter, Wim H A, Cortés, Javier, Saura, Cristina, Arribas, Joaquín

“…Trastuzumab-emtansine (T-DM1) is an antibody-drug conjugate (ADC) approved for the treatment of HER2 (human epidermal growth factor receptor 2)-positive breast…”
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Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody-Drug Conjugate by Groothuis, Patrick G, Jacobs, Daniëlle C H, Hermens, Inge A T, Damming, Désirée, Berentsen, Kim, Mattaar-Hepp, Ellen, Stokman, Marloes E M, Boekel, Tinie van, Rouwette, Myrthe, van der Vleuten, Monique A J, Sesink, Aloys, Dijcks, Fred A, Coumans, Ruud G E, Schouten, Jan, Glaudemans, Dirk H, Wijk, Daniëlle van, Blomenröhr, Marion, Kappers, Wendela A, Ubink, Ruud, van der Lee, Miranda M C, Dokter, Wim H A

“…MET, the cell-surface receptor for the hepatocyte growth factor/scatter factor, which is widely overexpressed in various solid cancer types, is an attractive…”
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Unraveling the Interaction between Carboxylesterase 1c and the Antibody-Drug Conjugate SYD985: Improved Translational PK/PD by Using Ces1c Knockout Mice by Ubink, Ruud, Dirksen, Eef H C, Rouwette, Myrthe, Bos, Ebo S, Janssen, Ingrid, Egging, David F, Loosveld, Eline M, van Achterberg, Tanja A, Berentsen, Kim, van der Lee, Miranda M C, Bichat, Francis, Raguin, Olivier, van der Vleuten, Monique A J, Groothuis, Patrick G, Dokter, Wim H A

“…Carboxylesterase 1c (CES1c) is responsible for linker-drug instability and poor pharmacokinetics (PK) of several antibody-drug conjugates (ADC) in mice, but…”
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Preclinical profile of the HER2-targeting ADC SYD983/SYD985: introduction of a new duocarmycin-based linker-drug platform by Dokter, Wim, Ubink, Ruud, van der Lee, Miranda, van der Vleuten, Monique, van Achterberg, Tanja, Jacobs, Danielle, Loosveld, Eline, van den Dobbelsteen, Diels, Egging, David, Mattaar, Ellen, Groothuis, Patrick, Beusker, Patrick, Coumans, Ruud, Elgersma, Ronald, Menge, Wiro, Joosten, John, Spijker, Henri, Huijbregts, Tijl, de Groot, Vincent, Eppink, Michel, de Roo, Guy, Verheijden, Gijs, Timmers, Marco

“…A linker-drug platform was built on the basis of a cleavable linker-duocarmycin payload for the development of new-generation antibody-drug conjugates (ADC). A…”
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Glucose kinetics in the collagen-induced arthritis model: an all-in-one model to assess both efficacy and metabolic side effects of glucocorticoids by Toonen, Erik J M, Laskewitz, Anke J, van Dijk, Theo H, Bleeker, Aycha, Grefhorst, Aldo, Schouten, Annelies E, Bastiaanssen, Ellen A J, Ballak, Dov B, Koenders, Marije I, van Doorn, Cindy, van der Vleuten, Monique A J, van Lierop, Marie-Jose C, Groen, Albert K, Dokter, Wim H A

“…Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory drugs, but chronic use is hampered by metabolic side effects. Therefore, there is an…”
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Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor by Frijters, Raoul, Fleuren, Wilco, Toonen, Erik J M, Tuckermann, Jan P, Reichardt, Holger M, van der Maaden, Hans, van Elsas, Andrea, van Lierop, Marie-Jose, Dokter, Wim, de Vlieg, Jacob, Alkema, Wynand

“…Glucocorticoids (GCs) control expression of a large number of genes via binding to the GC receptor (GR). Transcription may be regulated either by binding of…”
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A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA by Rouwendal, Gerard Ja, van der Lee, Miranda M, Meyer, Saskia, Reiding, Karli R, Schouten, Jan, de Roo, Guy, Egging, David F, Leusen, Jeanette Hw, Boross, Peter, Wuhrer, Manfred, Verheijden, Gijs F, Dokter, Wim H, Timmers, Marco, Ubink, Ruud

“…Monomeric IgA has been proposed as an alternative antibody format for cancer therapy. Here, we present our studies on the production, purification and…”
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Activation of Proteinase 3 Contributes to Nonalcoholic Fatty Liver Disease and Insulin Resistance by Toonen, Erik J M, Mirea, Andreea-Manuela, Tack, Cees J, Stienstra, Rinke, Ballak, Dov B, van Diepen, Janna A, Hijmans, Anneke, Chavakis, Triantafyllos, Dokter, Wim H, Pham, Christine T N, Netea, Mihai G, Dinarello, Charles A, Joosten, Leo A B

“…Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type…”
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Identification of gene signatures for prednisolone-induced metabolic dysfunction in collagen-induced arthritic mice by Ellero-Simatos, Sandrine, Fleuren, Wilco W M, Bauerschmidt, Susanne, Dokter, Wim H A, Toonen, Erik J M

“…Prednisolone is a potent anti-inflammatory glucocorticoid (GC) but chronic use is hampered by metabolic side effects. Little is known about the long-term…”
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Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type 2 Diabetes by Irwin, Nigel, Patterson, Steven, de Kort, Martin, Moffett, R. Charlotte, Wisse, Jeffry A. J., Dokter, Wim H. A., Bos, Ebo S., Miltenburg, André M. M., Flatt, Peter R.

“…The present study details the development of a family of novel D‐Ala8 glucagon‐like peptide‐1 (GLP‐1) peptide conjugates by site specific conjugation to an…”
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Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells by Linssen, Margot M.L., van Raalte, Daniel H., Toonen, Erik J.M., Alkema, Wynand, van der Zon, Gerard C., Dokter, Wim H., Diamant, Michaela, Guigas, Bruno, Ouwens, D. Margriet

“…Glucocorticoids (GCs), such as prednisolone (PRED), are widely prescribed anti-inflammatory drugs, but their use may induce glucose intolerance and diabetes…”
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BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells by van Helden, Mary J, Zwarthoff, Seline A, Arends, Roel J, Reinieren-Beeren, Inge M J, Paradé, Marc C B C, Driessen-Engels, Lilian, de Laat-Arts, Karin, Damming, Désirée, Santegoeds-Lenssen, Ellen W H, van Kuppeveld, Daphne W J, Lodewijks, Imke, Olsman, Hugo, Matlung, Hanke L, Franke, Katka, Mattaar-Hepp, Ellen, Stokman, Marloes E M, de Wit, Benny, Glaudemans, Dirk H R F, van Wijk, Daniëlle E J W, Joosten-Stoffels, Lonnie, Schouten, Jan, Boersema, Paul J, van der Vleuten, Monique, Sanderink, Jorien W H, Kappers, Wendela A, van den Dobbelsteen, Diels, Timmers, Marco, Ubink, Ruud, Rouwendal, Gerard J A, Verheijden, Gijs, van der Lee, Miranda M C, Dokter, Wim H A, van den Berg, Timo K

“…BackgroundPreclinical studies have firmly established the CD47-signal-regulatory protein (SIRP)α axis as a myeloid immune checkpoint in cancer, and this is…”
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Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index by van Lierop, Marie-José C, Alkema, Wynand, Laskewitz, Anke J, Dijkema, Rein, van der Maaden, Hans M, Smit, Martin J, Plate, Ralf, Conti, Paolo G M, Jans, Christan G J M, Timmers, C Marco, van Boeckel, Constant A A, Lusher, Scott J, McGuire, Ross, van Schaik, Rene C, de Vlieg, Jacob, Smeets, Ruben L, Hofstra, Claudia L, Boots, Annemieke M H, van Duin, Marcel, Ingelse, Benno A, Schoonen, Willem G E J, Grefhorst, Aldo, van Dijk, Theo H, Kuipers, Folkert, Dokter, Wim H A

“…Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin…”
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Assessing the metabolic effects of prednisolone in healthy volunteers using urine metabolic profiling by Ellero-Simatos, Sandrine, Szymańska, Ewa, Rullmann, Ton, Dokter, Wim Ha, Ramaker, Raymond, Berger, Ruud, van Iersel, Thijs Mp, Smilde, Age K, Hankemeier, Thomas, Alkema, Wynand

“…Glucocorticoids, such as prednisolone, are widely used anti-inflammatory drugs, but therapy is hampered by a broad range of metabolic side effects including…”
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