Search Results - "Dokoumetzidis, Aristides"

A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System by Dokoumetzidis, Aristides, Macheras, Panos

“…Dissolution research started to develop about 100 years ago as a field of physical chemistry and since then important progress has been made. However, explicit…”
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A Meta-Analysis Methodology in Stan to Estimate Population Pharmacokinetic Parameters from Multiple Aggregate Concentration-Time Datasets: Application to Gevokizumab mPBPK Model by Karakitsios, Evangelos, Dokoumetzidis, Aristides

“…The aim of the present study was to develop and evaluate the performance of a methodology to estimate the population pharmacokinetic (PK) parameters along with…”
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On the ubiquitous presence of fractals and fractal concepts in pharmaceutical sciences: A review by Pippa, Natassa, Dokoumetzidis, Aristides, Demetzos, Costas, Macheras, Panos

“…Fractals have been very successful in quantifying nature's geometrical complexity, and have captured the imagination of scientific community. The development…”
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Population Pharmacokinetic Modelling of the Complex Release Kinetics of Octreotide LAR: Defining Sub-Populations by Cluster Analysis by Kapralos, Iasonas, Dokoumetzidis, Aristides

“…The aim of the study is to develop a population pharmacokinetic (PPK) model, of Octreotide long acting repeatable (LAR) formulation in healthy volunteers,…”
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Donepezil Brain and Blood Pharmacokinetic Modeling after Nasal Film and Oral Solution Administration in Mice by Kaikousidis, Christos, Papakyriakopoulou, Paraskevi, Dokoumetzidis, Aristides, Valsami, Georgia

“…Intranasal delivery is a non-invasive mode of administration, gaining popularity due to its potential for targeted delivery to the brain. The anatomic…”
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Simulating realistic patient profiles from pharmacokinetic models by a machine learning postprocessing correction of residual variability by Kaikousidis, Christos, Bies, Robert R., Dokoumetzidis, Aristides

“…We address the problem of model misspecification in population pharmacokinetics (PopPK), by modeling residual unexplained variability (RUV) by machine learning…”
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Efficacy and safety of Mydriatic Microdrops for Retinopathy Of Prematurity Screening (MyMiROPS): study protocol for a non-inferiority crossover randomized controlled trial by Seliniotaki, Aikaterini K, Haidich, Anna-Bettina, Lithoxopoulou, Maria, Gika, Helen, Boutou, Eleftheria, Virgiliou, Christina, Nikolaidou, Martha, Dokoumetzidis, Aristides, Raikos, Nikolaos, Diamanti, Elisavet, Ziakas, Nikolaos, Mataftsi, Asimina

“…Retinopathy of prematurity (ROP) eye examination screening presupposes adequate mydriasis for an informative fundoscopy of preterm infants at risk, on a weekly…”
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Development of a Population Pharmacokinetic Model of Busulfan in Children and Evaluation of Different Sampling Schedules for Precision Dosing by Neroutsos, Efthymios, Nalda-Molina, Ricardo, Paisiou, Anna, Zisaki, Kalliopi, Goussetis, Evgenios, Spyridonidis, Alexandros, Kitra, Vasiliki, Grafakos, Stelios, Valsami, Georgia, Dokoumetzidis, Aristides

“…We develop a population pharmacokinetic model to describe Busulfan pharmacokinetics in paediatric patients and investigate by simulations the impact of various…”
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Pharmacokinetic Characteristics of Nebulized Colistimethate Sodium Using Two Different Types of Nebulizers in Critically Ill Patients with Ventilator-Associated Respiratory Infections by Kyriakoudi, Anna, Pontikis, Konstantinos, Valsami, Georgia, Avgeropoulou, Stavrina, Neroutsos, Efthymios, Christodoulou, Eirini, Moraitou, Eleni, Markantonis, Sophia L, Dokoumetzidis, Aristides, Rello, Jordi, Koutsoukou, Antonia

“…Background: Rising antimicrobial resistance has led to a revived interest in inhaled colistin treatment in the critically ill patient with…”
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Developing Clinically Relevant Dissolution Specifications (CRDSs) for Oral Drug Products: Virtual Webinar Series by McAllister, Mark, Flanagan, Talia, Cole, Susan, Abend, Andreas, Kotzagiorgis, Evangelos, Limberg, Jobst, Mead, Heather, Mangas-Sanjuan, Victor, Dickinson, Paul A, Moir, Andrea, Pepin, Xavier, Zhou, Diansong, Tistaert, Christophe, Dokoumetzidis, Aristides, Anand, Om, Le Merdy, Maxime, Turner, David B, Griffin, Brendan T, Darwich, Adam, Dressman, Jennifer, Mackie, Claire

“…A webinar series that was organised by the Academy of Pharmaceutical Sciences Biopharmaceutics focus group in 2021 focused on the challenges of developing…”
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Predictive models for oral drug absorption: from in silico methods to integrated dynamical models by Dokoumetzidis, Aristides, Kalantzi, Lida, Fotaki, Nikoletta

“…Poor oral absorption is one of the most common reasons for a drug to be terminated during development. Oral drug absorption is a complex process affected by…”
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Extrapolation of lung pharmacokinetics of antitubercular drugs from preclinical species to humans using PBPK modelling by Karakitsios, Evangelos, Dokoumetzidis, Aristides

“…To develop physiologically based pharmacokinetic (PBPK) models for widely used anti-TB drugs, namely rifampicin, pyrazinamide, isoniazid, ethambutol and…”
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In Silico Dosimetry Study of Tc99m-Tetrofosmin in Children Using a Novel PBPK Model in Humans Built from SPECT Imaging Data by Kaikousidis, Christos, Dokoumetzidis, Aristides

“…Purpose The aim of this work is to develop a Physiologically Based Pharmacokinetic model (PBPK) for the radiopharmaceutical Tc99m-Tetrofosmin in humans, from…”
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Implementation of non-linear mixed effects models defined by fractional differential equations by Kaikousidis, Christos, Dokoumetzidis, Aristides

“…Fractional differential equations (FDEs), i.e. differential equations with derivatives of non-integer order, can describe certain experimental datasets more…”
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Minocycline susceptibility breakpoints for Acinetobacter baumannii: do we need to re-evaluate them? by Tsakris, Athanasios, Koumaki, Vasiliki, Dokoumetzidis, Aristides

“…Abstract Minocycline is an old broad-spectrum tetracycline indicated for the treatment of various infections, including those due to minocycline-susceptible…”
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Fractional kinetics in drug absorption and disposition processes by Dokoumetzidis, Aristides, Macheras, Panos

“…We explore the use of fractional order differential equations for the analysis of datasets of various drug processes that present anomalous kinetics, i.e…”
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Fractional calculus in pharmacokinetics by Sopasakis, Pantelis, Sarimveis, Haralambos, Macheras, Panos, Dokoumetzidis, Aristides

“…We are witnessing the birth of a new variety of pharmacokinetics where non-integer-order differential equations are employed to study the time course of drugs…”
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A physiologically based approach for the estimation of recirculatory parameters by Karalis, Vangelis, Dokoumetzidis, Aristides, Macheras, Panos

“…Indicator dilution studies are used to provide estimates for several physiological parameters such as cardiac output as well as intra- and extravascular…”
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The Changing Face of the Rate Concept in Biopharmaceutical Sciences: From Classical to Fractal and Finally to Fractional by Dokoumetzidis, Aristides, Macheras, Panos

“…The common and most principal component of the underlying mechanism of numerous drug processes is diffusion. The diffusion of molecules at the microscopic…”
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Monte Carlo simulation of temocillin 6 g daily administered by continuous infusion or intermittent dosage by Tsakris, Athanasios, Koumaki, Vasiliki, Dokoumetzidis, Aristides, Balakrishnan, Indran

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