Search Results - "Doka, Gabriel"

Isolated downregulation of HCN2 in ventricles of rats with streptozotocin-induced diabetic cardiomyopathy by Hadova, Katarina, Kralova, Eva, Doka, Gabriel, Bies Pivackova, Lenka, Kmecova, Zuzana, Krenek, Peter, Klimas, Jan

“…In spite of disrupted repolarization of diabetic heart, some studies report less tendency of diabetic heart to develop ventricular arrhythmias suggesting…”
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Pioglitazone restores phosphorylation of downregulated caveolin-1 in right ventricle of monocrotaline-induced pulmonary hypertension by Malikova, Eva, Kmecova, Zuzana, Doka, Gabriel, Pivackova, Lenka Bies, Balis, Peter, Trubacova, Simona, Velasova, Eva, Krenek, Peter, Klimas, Jan

“…Caveolin-1 (cav-1) plays a role in pulmonary arterial hypertension (PAH). Monocrotaline (MCT)-induced PAH is characterized by a loss of cav-1 in pulmonary…”
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Rapid changes of mRNA expressions of cardiac ion channels affected by Torsadogenic drugs influence susceptibility of rat hearts to arrhythmias induced by Beta‐Adrenergic stimulation by Hadova, Katarina, Kmecova, Jana, Ochodnicka‐Mackovicova, Katarina, Kralova, Eva, Doka, Gabriel, Bies Pivackova, Lenka, Vavrinec, Peter, Stankovicova, Tatiana, Krenek, Peter, Klimas, Jan

“…Abstract Drug‐induced long QT syndrome (LQTS) and Torsades de Pointes (TdP) are serious concerns in drug development. Although rats are a useful scientific…”
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mRNA levels of circadian clock components Bmal1 and Per2 alter independently from dosing time-dependent efficacy of combination treatment with valsartan and amlodipine in spontaneously hypertensive rats by Potucek, Peter, Radik, Michal, Doka, Gabriel, Kralova, Eva, Krenek, Peter, Klimas, Jan

“…Chronopharmacological effects of antihypertensives play a role in the outcome of hypertension therapy. However, studies produce contradictory findings when…”
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Upregulation of SERCA2a following short-term ACE inhibition (by enalaprilat) alters contractile performance and arrhythmogenicity of healthy myocardium in rat by Matus, Marek, Kucerova, Dana, Kruzliak, Peter, Adameova, Adriana, Doka, Gabriel, Turcekova, Katarina, Kmecova, Jana, Kyselovic, Jan, Krenek, Peter, Kirchhefer, Uwe, Mueller, Frank U., Boknik, Peter, Klimas, Jan

“…Chronic angiotensin-converting enzyme inhibitor (ACEIs) treatment can suppress arrhythmogenesis. To examine whether the effect is more immediate and…”
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RIOCIGUAT-INDUCED DOWNREGULATION OF GENES RESPONSIBLE FOR SODIUM TRANSPORT THROUGH THE ALVEOLAR EPITHELIUM IN THE MONOCROTALINE MODEL OF PULMONARY HYPERTENSION by Lelková, Katarína, Velasova, Eva, Kmecova, Zuzana, Veteskova, Jana, Pivackova, Lenka Bies, Doka, Gabriel, Babal, Pavel, Klimas, Jan, Krenek, Peter

“…Objective: Pleural effusions (PLEF) in patients with pulmonary arterial hypertension (PAH) co-diagnosed with isolated right-sided heart failure (RHF) have been…”
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The tyrosine kinase inhibitor crizotinib influences blood glucose and mRNA expression of GLUT4 and PPARs in the heart of rats with experimental diabetes by Hadova, Katarina, Mesarosova, Lucia, Kralova, Eva, Doka, Gabriel, Krenek, Peter, Klimas, Jan

“…Tyrosine kinases inhibitors (TKIs) may alter glycaemia and may be cardiotoxic with importance in the diabetic heart. We investigated the effect of multi-TKI…”
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SHORT-TERM CRIZOTINIB TREATMENT REVERSES GLUT4 GLUCOSE TRANSPORTER DOWNREGULATION IN DIABETIC RAT HEART by Hadova, Katarina, Mesarosova, Lucia, Doka, Gabriel, Pivackova, Lenka Bies, Krenek, Peter, Klimas, Jan

“…Objective: Crizotinib is a multitarget ALK/c-MET/ROS1/RON inhibitor that can potentially inhibit non-intended receptor tyrosine kinases (RTKs) which play a…”
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Ramipril restores PPARβ/δ and PPARγ expressions and reduces cardiac NADPH oxidase but fails to restore cardiac function and accompanied myosin heavy chain ratio shift in severe anthracycline-induced cardiomyopathy in rat by Cernecka, Hana, Doka, Gabriel, Srankova, Jasna, Pivackova, Lenka, Malikova, Eva, Galkova, Kristina, Kyselovic, Jan, Krenek, Peter, Klimas, Jan

“…We hypothesized that peroxisome proliferator-activated receptors (PPARs) might be involved in a complex protective action of ACE inhibitors (ACEi) in…”
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Pegfilgrastim and linagliptin potentiate chemoattraction of Ccr2 and Cd44 stem cells accompanied by alterations of cardiac Hgf, Igf‐1 and Mcp‐1 in daunorubicin cardiomyopathy by Srankova, Jasna, Veteskova, Jana, Marusakova, Margareta, Pivackova, Lenka, Doka, Gabriel, Krenek, Peter, Klimas, Jan

“…Objective Daunorubicin (DAU) downregulates cytokines promoting stem cell migration and homing into the heart, reducing cardiac regeneration after anticancer…”
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CHANGES IN MUSCLE-SPECIFIC MICRORNAS ACCOMPANY TERMINAL STAGES OF MONOCROTALINE-INDUCED PULMONARY HYPERTENSION IN RAT by Kmecova, Zuzana, Veteskova, Jana, Zirova, Katarina, Pivackova, Lenka Bies, Doka, Gabriel, Malikova, Eva, Krenek, Peter, Passakova, Nina, Paulis, Ludovit, Luknar, Milan, Goncalvesova, Eva, Klimas, Jan

“…Objective: Importance of muscle-specific microRNAs (miR-1/miR-133a/miR-208/miR-499) has been identified in various cardiovascular pathologies, including their…”
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Downregulation of myogenic microRNAs in sub-chronic but not in sub-acute model of daunorubicin-induced cardiomyopathy by Doka, Gabriel, Malikova, Eva, Galkova, Kristina, La Rocca, Giampiero, Kruzliak, Peter, Adamek, Mariusz, Rodrigo, Luis, Krenek, Peter, Klimas, Jan

“…Cardiac muscle-related microRNAs play important roles in cardiac development and disease by translational silencing of mRNAs, the dominant mechanism of…”
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Disease severity–related alterations of cardiac microRNAs in experimental pulmonary hypertension by Kmecova, Zuzana, Veteskova, Jana, Lelkova‐Zirova, Katarina, Bies Pivackova, Lenka, Doka, Gabriel, Malikova, Eva, Paulis, Ludovit, Krenek, Peter, Klimas, Jan

“…Right ventricular (RV) failure is the primary cause of death in pulmonary arterial hypertension (PAH). We hypothesized that heart‐relevant microRNAs, that is…”
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Opposite alterations of endothelin-1 in lung and pulmonary artery mirror gene expression of bone morphogenetic protein receptor 2 in experimental pulmonary hypertension by Veteskova, Jana, Kmecova, Zuzana, Malikova, Eva, Doka, Gabriel, Radik, Michal, Vavrinec, Peter, Krenek, Peter, Klimas, Jan

“…Aim of the Study: Endothelin-1 (ET-1) overexpression was suggested to play a role in pulmonary hypertension (PH). However, the roles of ET-1 in early stages of…”
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Daunorubicin Down‐Regulates the Expression of Stem Cell Markers and Factors Involved in Stem Cell Migration and Homing in Rat Heart in Subchronic but not Acute Cardiomyopathy by Srankova, Jasna, Doka, Gabriel, Pivackova, Lenka, Mesarosova, Lucia, Kyselovic, Jan, Klimas, Jan, Krenek, Peter

“…We tested the hypothesis that daunorubicin (DAU) cardiotoxicity alters expression of cytokines involved in stem cell migration and homing. Male Wistar rats…”
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l‐Arginine Attenuates Cardiac Dysfunction, But Further Down‐Regulates α‐Myosin Heavy Chain Expression in Isoproterenol‐Induced Cardiomyopathy by Kralova, Eva, Doka, Gabriel, Pivackova, Lenka, Srankova, Jasna, Kuracinova, Kristina, Janega, Pavol, Babal, Pavel, Klimas, Jan, Krenek, Peter

“…In view of previously reported increased capacity for nitric oxide production, we suggested that l‐arginine (ARG), the nitric oxide synthase (NOS) substrate,…”
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Enalaprilat increases PPARβ/δ expression, without influence on PPARα and PPARγ, and modulate cardiac function in sub-acute model of daunorubicin-induced cardiomyopathy by Cernecka, Hana, Ochodnicka-Mackovicova, Katarina, Kucerova, Dana, Kmecova, Jana, Nemcekova, Viera, Doka, Gabriel, Kyselovic, Jan, Krenek, Peter, Ochodnicky, Peter, Klimas, Jan

“…Anthracycline therapy is limited by a cardiotoxicity that may eventually lead to chronic heart failure which is thought to be prevented by ACE inhibitors…”
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Alterations in L-type calcium channel expression are involved in drug-induced repolarization cardiotoxicity by Klimas, Jan, Doka, Gabriel, Klimasova-Kmecova, Jana, Kralova, Eva, Ochodnicka-Mackovicova, Katarina, Stankovicova, Tatiana, Vavrinec, Peter, Ochodnicky, Peter, Krenek, Peter

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l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates [alpha]-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy by Kralova, Eva, Doka, Gabriel, Pivackova, Lenka, Srankova, Jasna, Kuracinova, Kristina, Janega, Pavol, Babal, Pavel, Klimas, Jan, Krenek, Peter

“…In view of previously reported increased capacity for nitric oxide production, we suggested that l-arginine (ARG), the nitric oxide synthase (NOS) substrate,…”
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CHANGES IN MUSCLE-SPECIFIC MICRORNAS ACCOMPANY TERMINAL STAGES OF MONOCROTALINE-INDUCED PULMONARY HYPERTENSION IN RAT by Kmecova, Zuzana, Veteskova, Jana, Zirova, Katarina, Pivackova, Lenka Bies, Doka, Gabriel, Malikova, Eva, Krenek, Peter, Passakova, Nina, Paulis, Ludovit, Luknar, Milan, Goncalvesova, Eva, Klimas, Jan

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