Search Results - "Doi, Satoki"

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders by Noji, Satoru, Hara, Yoshinori, Miura, Tomoya, Yamanaka, Hiroshi, Maeda, Katsuya, Hori, Akimi, Yamamoto, Hiroshi, Obika, Shingo, Inoue, Masafumi, Hase, Yasunori, Orita, Takuya, Doi, Satoki, Adachi, Tsuyoshi, Tanimoto, Atsuo, Oki, Chika, Kimoto, Yukari, Ogawa, Yoshihiro, Negoro, Tamotsu, Hashimoto, Hiromasa, Shiozaki, Makoto

“…Dermatologic disorders such as atopic dermatitis arise from genetic and environmental causes and are complex and multifactorial in nature. Among possible risk…”
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Broad Antiretroviral Activity and Resistance Profile of the Novel Human Immunodeficiency Virus Integrase Inhibitor Elvitegravir (JTK-303/GS-9137) by SHIMURA, Kazuya, KODAMA, Eiichi, KANO, Mitsuki, IKEDA, Satoru, MATSUOKA, Masao, SAKAGAMI, Yasuko, MATSUZAKI, Yuji, WATANABE, Wataru, YAMATAKA, Kazunobu, WATANABE, Yasuo, OHATA, Yoshitsugu, DOI, Satoki, SATO, Motohide

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Discovery of Conformationally Constrained Tetracyclic Compounds as Potent Hepatitis C Virus NS5B RNA Polymerase Inhibitors by Ikegashira, Kazutaka, Oka, Takahiro, Hirashima, Shintaro, Noji, Satoru, Yamanaka, Hiroshi, Hara, Yoshinori, Adachi, Tsuyoshi, Tsuruha, Jun-Ichiro, Doi, Satoki, Hase, Yasunori, Noguchi, Toru, Ando, Izuru, Ogura, Naoki, Ikeda, Satoru, Hashimoto, Hiromasa

“…We report a new series of hepatitis C virus NS5B RNA polymerase inhibitors containing a conformationally constrained tetracyclic scaffold. SAR studies led to…”
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Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques by Asano, Wataru, Yamanaka, Kenji, Ohara, Yasunori, Uhara, Toru, Doi, Satoki, Orita, Takuya, Iwanaga, Tomoko, Adachi, Tsuyoshi, Fujioka, Shingo, Akaki, Tatsuo, Ikegashira, Kazutaka, Hantani, Yoshiji

“…Tyrosine phosphorylation is an essential post-translational modification that regulates various biological events and is implicated in many diseases including…”
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Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases by Akaki, Tatsuo, Bessho, Yuki, Ito, Takashi, Fujioka, Shingo, Ubukata, Minoru, Mori, Genki, Yamanaka, Kenji, Orita, Takuya, Doi, Satoki, Iwanaga, Tomoko, Ikegashira, Kazutaka, Hantani, Yoshiji, Nakanishi, Isao, Adachi, Tsuyoshi

“…[Display omitted] A fragment-based lead discovery approach was applied to Pyruvate Dehydrogenase Kinases (PDHKs) to discover inhibitors against the ATP binding…”
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The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action by Kitao, Yuki, Saito, Tadataka, Watanabe, Satoshi, Ohe, Yasuhiro, Takahashi, Koichi, Akaki, Tatsuo, Adachi, Tsuyoshi, Doi, Satoki, Yamanaka, Kenji, Murai, Yasutaka, Oba, Makoto, Suzuki, Takayoshi

“…[Display omitted] AMP deaminase 2 (AMPD2) has been thought to play an important role in energy homeostasis and immuno-oncology, while selective AMPD2…”
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Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models by Ikegashira, Kazutaka, Ikenogami, Taku, Yamasaki, Takayuki, Hase, Yasunori, Yamaguchi, Takayuki, Inagaki, Koji, Doi, Satoki, Adachi, Tsuyoshi, Koga, Yoshihisa, Hashimoto, Hiromasa

“…[Display omitted] •A novel series of azetidine scaffold were identified as colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors.•Compound 4a showed…”
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Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold by Kotoku, Masayuki, Maeba, Takaki, Fujioka, Shingo, Yokota, Masahiro, Seki, Noriyoshi, Ito, Keisuke, Suwa, Yoshihiro, Ikenogami, Taku, Hirata, Kazuyuki, Hase, Yasunori, Katsuda, Yoshiaki, Miyagawa, Naoki, Arita, Kojo, Asahina, Kota, Noguchi, Masato, Nomura, Akihiro, Doi, Satoki, Adachi, Tsuyoshi, Crowe, Paul, Tao, Haiyan, Thacher, Scott, Hashimoto, Hiromasa, Suzuki, Takayoshi, Shiozaki, Makoto

“…Starting from a previously reported RORγ inhibitor (1), successive efforts to improve in vivo potency were continued. Introduction of metabolically beneficial…”
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Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors by Bessho, Yuki, Akaki, Tatsuo, Hara, Yoshinori, Yamakawa, Maki, Obika, Shingo, Mori, Genki, Ubukata, Minoru, Yasue, Katsutaka, Nakane, Yoshitomi, Terasako, Yasuo, Orita, Takuya, Doi, Satoki, Iwanaga, Tomoko, Fujishima, Ayumi, Adachi, Tsuyoshi, Ueno, Hiroshi, Motomura, Takahisa

“…[Display omitted] Pyruvate dehydrogenase kinases (PDHKs) are fascinating drug targets for numerous diseases, including diabetes and cancers. In this report, we…”
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Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction by Noguchi, Masato, Nomura, Akihiro, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Maeda, Katsuya, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Crowe, Paul, Tao, Haiyan, Thacher, Scott, Adachi, Tsuyoshi

“…Retinoic acid-related orphan receptor gamma (RORγ) plays pivotal roles in autoimmune diseases by controlling the lineage of interleukin 17 (IL-17)-producing…”
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SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor by Hirata, Kazuyuki, Kotoku, Masayuki, Seki, Noriyoshi, Maeba, Takaki, Maeda, Katsuya, Hirashima, Shintaro, Sakai, Takayuki, Obika, Shingo, Hori, Akimi, Hase, Yasunori, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Hata, Takahiro, Miyagawa, Naoki, Arita, Kojo, Nomura, Yukihiro, Asahina, Kota, Aratsu, Yusuke, Kamada, Masafumi, Adachi, Tsuyoshi, Noguchi, Masato, Doi, Satoki, Crowe, Paul, Bradley, Erin, Steensma, Ruo, Tao, Haiyan, Fenn, Morgan, Babine, Robert, Li, Xiaolin, Thacher, Scott, Hashimoto, Hiromasa, Shiozaki, Makoto

“…A novel series of RORγ inhibitors was identified starting with the HTS hit 1. After SAR investigation based on a prospective consideration of two drug-likeness…”
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Ternary complex of human ROR[gamma] ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment by Noguchi, Masato, Nomura, Akihiro, Murase, Ken, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Steensma, Ruo, Li, Xioalin, Tao, Haiyan, Tse, Bruno, Fenn, Morgan, Babine, Robert, Bradley, Erin, Crowe, Paul, Thacher, Scott, Adachi, Tsuyoshi, Kamada, Masafumi

“…Retinoid-related orphan receptor gamma (ROR[gamma]) directly controls the differentiation of Th17 cell and the production of interleukin-17, which plays an…”
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Ternary complex of human RORγ ligand‐binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment by Noguchi, Masato, Nomura, Akihiro, Murase, Ken, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Steensma, Ruo, Li, Xioalin, Tao, Haiyan, Tse, Bruno, Fenn, Morgan, Babine, Robert, Bradley, Erin, Crowe, Paul, Thacher, Scott, Adachi, Tsuyoshi, Kamada, Masafumi

“…Retinoid‐related orphan receptor gamma (RORγ) directly controls the differentiation of Th17 cell and the production of interleukin‐17, which plays an integral…”
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SAR Exploration Guided by LE and Fsp3: Discovery of a Selective and Orally Efficacious RORγ Inhibitor by Hirata, Kazuyuki, Kotoku, Masayuki, Seki, Noriyoshi, Maeba, Takaki, Maeda, Katsuya, Hirashima, Shintaro, Sakai, Takayuki, Obika, Shingo, Hori, Akimi, Hase, Yasunori, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Hata, Takahiro, Miyagawa, Naoki, Arita, Kojo, Nomura, Yukihiro, Asahina, Kota, Aratsu, Yusuke, Kamada, Masafumi, Adachi, Tsuyoshi, Noguchi, Masato, Doi, Satoki, Crowe, Paul, Bradley, Erin, Steensma, Ruo, Tao, Haiyan, Fenn, Morgan, Babine, Robert, Li, Xiaolin, Thacher, Scott, Hashimoto, Hiromasa, Shiozaki, Makoto

“…A novel series of RORγ inhibitors was identified starting with the HTS hit 1. After SAR investigation based on a prospective consideration of two drug-likeness…”
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SAR Exploration Guided by LE and Fsp 3 : Discovery of a Selective and Orally Efficacious RORγ Inhibitor by Hirata, Kazuyuki, Kotoku, Masayuki, Seki, Noriyoshi, Maeba, Takaki, Maeda, Katsuya, Hirashima, Shintaro, Sakai, Takayuki, Obika, Shingo, Hori, Akimi, Hase, Yasunori, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Hata, Takahiro, Miyagawa, Naoki, Arita, Kojo, Nomura, Yukihiro, Asahina, Kota, Aratsu, Yusuke, Kamada, Masafumi, Adachi, Tsuyoshi, Noguchi, Masato, Doi, Satoki, Crowe, Paul, Bradley, Erin, Steensma, Ruo, Tao, Haiyan, Fenn, Morgan, Babine, Robert, Li, Xiaolin, Thacher, Scott, Hashimoto, Hiromasa, Shiozaki, Makoto

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