Search Results - "Doi, Naoya"

Commentary: Origin and evolution of pathogenic coronaviruses by Adachi, Shun, Koma, Takaaki, Doi, Naoya, Nomaguchi, Masako, Adachi, Akio

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HIV-1 mutates to adapt in fluxing environments by Nomaguchi, Masako, Doi, Naoya, Koma, Takaaki, Adachi, Akio

“…Human immunodeficiency virus type 1 (HIV-1) is specifically adapted for replication, persistence, transmission, and survival in humans. HIV-1 is highly mutable…”
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Toward Understanding Molecular Bases for Biological Diversification of Human Coronaviruses: Present Status and Future Perspectives by Koma, Takaaki, Adachi, Shun, Doi, Naoya, Adachi, Akio, Nomaguchi, Masako

“…Human coronaviruses (HCoVs) are of zoonotic origins, and seven distinct HCoVs are currently known to infect humans. While the four seasonal HCoVs appear to be…”
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Expression Level of HIV-1 Vif Can Be Fluctuated by Natural Nucleotide Variations in the vif -Coding and Regulatory SA1D2prox Sequences of the Proviral Genome by Doi, Naoya, Koma, Takaaki, Adachi, Akio, Nomaguchi, Masako

“…Vif is required for HIV-1 replication in natural target cells by counteracting host restriction factors, APOBEC3 (A3) proteins. We recently demonstrated that…”
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Allosteric Regulation of HIV-1 Capsid Structure for Gag Assembly, Virion Production, and Viral Infectivity by a Disordered Interdomain Linker by Koma, Takaaki, Kotani, Osamu, Miyakawa, Kei, Ryo, Akihide, Yokoyama, Masaru, Doi, Naoya, Adachi, Akio, Sato, Hironori, Nomaguchi, Masako

“…The retroviral Gag capsid (Gag-CA) interdomain linker is an unstructured peptide segment connecting structured N-terminal and C-terminal domains. Although the…”
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Involvement of a Rarely Used Splicing SD2b Site in the Regulation of HIV-1 vif mRNA Production as Revealed by a Growth-Adaptive Mutation by Koma, Takaaki, Doi, Naoya, Le, Bao Quoc, Kondo, Tomoyuki, Ishizue, Mitsuki, Tokaji, Chiaki, Tsukada, Chizuko, Adachi, Akio, Nomaguchi, Masako

“…We have previously reported an HIV-1 mutant designated NL-Y226tac that expresses Vif at an ultra-low level, being replication-defective in high-APOBEC3G cells,…”
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Commentary: Derivation of Simian Tropic HIV-1 Infectious Clone Reveals Virus Adaptation to a New Host by Adachi, Akio, Koma, Takaaki, Doi, Naoya, Nomaguchi, Masako

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Concomitant Enhancement of HIV-1 Replication Potential and Neutralization-Resistance in Concert With Three Adaptive Mutations in Env V1/C2/C4 Domains by Doi, Naoya, Yokoyama, Masaru, Koma, Takaaki, Kotani, Osamu, Sato, Hironori, Adachi, Akio, Nomaguchi, Masako

“…HIV-1 Env protein functions in the entry process and is the target of neutralizing antibodies. Its intrinsically high mutation rate is certainly one of driving…”
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The Expression Level of HIV-1 Vif Is Optimized by Nucleotide Changes in the Genomic SA1D2prox Region during the Viral Adaptation Process by Koma, Takaaki, Doi, Naoya, Takemoto, Mai, Watanabe, Kyosuke, Yamamoto, Hideki, Nakashima, Satoshi, Adachi, Akio, Nomaguchi, Masako

“…HIV-1 Vif plays an essential role in viral replication by antagonizing anti-viral cellular restriction factors, a family of APOBEC3 proteins. We have…”
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Natural Single-Nucleotide Variations in the HIV-1 Genomic SA1prox Region Can Alter Viral Replication Ability by Regulating Vif Expression Levels by Nomaguchi, Masako, Doi, Naoya, Sakai, Yosuke, Ode, Hirotaka, Iwatani, Yasumasa, Ueno, Takamasa, Matsumoto, Yui, Miyazaki, Yasuyuki, Masuda, Takao, Adachi, Akio

“…We previously found that natural single-nucleotide variations located within a proximal region of splicing acceptor 1 (SA1prox) in the HIV-1 genome could alter…”
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Generation and characterization of new CCR5-tropic HIV-1rmt clones by Doi, Naoya, Sakai, Yosuke, Adachi, Akio, Nomaguchi, Masako

“…To develop effective non-human primate models for coping with numerous HIV-1/AIDS studies, rhesus macaque-tropic HIV-1 (HIV-1rmt) clones with a variety of…”
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Humanized mice generated by intra-bone marrow injection of CD133-positive hematopoietic stem cells: application to HIV-1 research by Koma, Takaaki, Odaka, Tokifumi, Lee, Sung-Il, Doi, Naoya, Kondo, Tomoyuki, Okuma, Kazu, Fujisawa, Jun-Ichi, Adachi, Akio, Nomaguchi, Masako

“…Animal models are essential for basic and clinical research on virus diseases. Humanized mice (mice reconstituted with human hematopoietic cells) have been…”
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Generation of Rhesus Macaque-Tropic HIV-1 Clones That Are Resistant to Major Anti-HIV-1 Restriction Factors by Nomaguchi, Masako, Yokoyama, Masaru, Kono, Ken, Nakayama, Emi E, Shioda, Tatsuo, Doi, Naoya, Fujiwara, Sachi, Saito, Akatsuki, Akari, Hirofumi, Miyakawa, Kei, Ryo, Akihide, Ode, Hirotaka, Iwatani, Yasumasa, Miura, Tomoyuki, Igarashi, Tatsuhiko, Sato, Hironori, Adachi, Akio

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Virological characterization of HIV‐1 CA‐NTD mutants constructed in a virus‐lineage reflected manner by Nakanishi, Shoko, Watanabe, Sakimi, Doi, Naoya, Koma, Takaaki, Adachi, Akio, Nomaguchi, Masako

“…Capsid (CA) protein is a major virion‐constituent of all retroviruses including human immunodeficiency virus type 1 (HIV‐1), and is essential for early and…”
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Role for Gag-CA Interdomain Linker in Primate Lentiviral Replication by Doi, Naoya, Koma, Takaaki, Adachi, Akio, Nomaguchi, Masako

“…Gag proteins underlie retroviral replication by fulfilling numerous functional roles at various stages during viral life cycle. Out of the four mature…”
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Phylogenetic Insights into the Functional Relationship between Primate Lentiviral Reverse Transcriptase and Accessory Proteins Vpx/Vpr by Sakai, Yosuke, Doi, Naoya, Miyazaki, Yasuyuki, Adachi, Akio, Nomaguchi, Masako

“…The efficiency of reverse transcription to synthesize viral DNA in infected cells greatly influences replication kinetics of retroviruses. However, viral…”
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Novel In Vitro Screening System Based on Differential Scanning Fluorimetry to Search for Small Molecules against the Disassembly or Assembly of HIV-1 Capsid Protein by Miyazaki, Yasuyuki, Doi, Naoya, Koma, Takaaki, Adachi, Akio, Nomaguchi, Masako

“…Varieties of systems have been used to study biochemical properties of human immunodeficiency virus Gag-capsid protein (HIV Gag-CA). Recently, we have…”
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Major target for UV-induced complete loss of HIV-1 infectivity: A model study of single-stranded RNA enveloped viruses by Koma, Takaaki, Doi, Naoya, Suzuki, Akihiro, Nagamatsu, Kentaro, Yasui, Takeshi, Yasutomo, Koji, Adachi, Akio, Minamikawa, Takeo, Nomaguchi, Masako

“…Deep ultraviolet light (UV) is useful for the disinfection of microorganisms, including bacteria and viruses. Although genome damage by UV has been widely…”
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In silico Analysis of HIV-1 Env-gp120 Reveals Structural Bases for Viral Adaptation in Growth-Restrictive Cells by Yokoyama, Masaru, Nomaguchi, Masako, Doi, Naoya, Kanda, Tadahito, Adachi, Akio, Sato, Hironori

“…Variable V1/V2 and V3 loops on human immunodeficiency virus type 1 (HIV-1) envelope-gp120 core play key roles in modulating viral competence to recognize two…”
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CXCR4- and CCR5-Tropic HIV-1 Clones Are Both Tractable to Grow in Rhesus Macaques by Doi, Naoya, Miura, Tomoyuki, Mori, Hiromi, Sakawaki, Hiromi, Koma, Takaaki, Adachi, Akio, Nomaguchi, Masako

“…A major issue for present HIV-1 research is to establish model systems that reflect or mimic viral replication and pathogenesis actually observed in infected…”
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